| Gene Symbol | hmp-2 |
| Entrez Gene ID | 173338 |
| Full Name | Beta-catenin-like protein hmp-2 |
| Gene Type | protein-coding |
| Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » hmp-2 cDNA ORF clone
| Gene Symbol | hmp-2 |
| Entrez Gene ID | 173338 |
| Full Name | Beta-catenin-like protein hmp-2 |
| Gene Type | protein-coding |
| Organism | Caenorhabditis elegans |
| mRNA | Protein | Name |
|---|---|---|
| NM_001265497.2 | NP_001252426.1 | Beta-catenin-like protein hmp-2 |
| NM_001265497.1 | NP_001252426.1 | Beta-catenin-like protein hmp-2 |
| NM_001265496.1 | NP_001252425.1 | Beta-catenin-like protein hmp-2 |
| NM_001265496.2 | NP_001252425.1 | Beta-catenin-like protein hmp-2 |
| Pan troglodytes (chimpanzee) | CTNNB1 | XP_001138023.1 |
| Bos taurus (cattle) | CTNNB1 | NP_001069609.1 |
| Danio rerio (zebrafish) | ctnnb1 | NP_571134.2 |
| Mus musculus (house mouse) | Ctnnb1 | NP_001159374.1 |
| Rattus norvegicus (Norway rat) | Ctnnb1 | NP_445809.2 |
| Gallus gallus (chicken) | CTNNB1 | NP_990412.1 |
| Homo sapiens (human) | CTNNB1 | NP_001091679.1 |
| Drosophila melanogaster (fruit fly) | arm | NP_996328.1 |
| Anopheles gambiae (African malaria mosquito) | ARM_ANOGA | XP_309245.5 |
| Caenorhabditis elegans (roundworm) | hmp-2 | NP_001252426.1 |
| Canis lupus familiaris (dog) | CTNNB1 | NP_001131124.1 |
| CTNNB1 | XP_002802886.1 | |
| Xenopus tropicalis (tropical clawed frog) | ctnnb1 | NP_001016958.1 |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Deletion analysis based on the crystal structure shows that the first helix of HMP-1 is necessary for binding HMP-2 avidly in vitro and for efficient recruitment of HMP-1 to adherens junctions in embryos. HMP-2 Ser-47 and Tyr-69 flank its binding interface with HMP-1, and we show that phosphomimetic mutations at these two sites decrease binding affinity of HMP-1 to HMP-2 by 40-100-fold
Title: Cell-cell adhesion in metazoans relies on evolutionarily conserved features of the ?-catenin??-catenin-binding interface.
HMP-1 bound filamentous actin with an affinity in the single micromolar range, even when complexed with the beta-catenin homolog HMP-2 or when present in a complex of HMP-2 and the cadherin homolog HMR-1, indicating that HMP-1 binding to F-actin is not allosterically regulated by the HMP-2.HMR-1 complex.
Title: Structural and functional characterization of
The beta-catenin HMP-2 functions downstream of Src in parallel with the Wnt pathway in early embryogenesis of C. elegans.
Title: The ?-catenin HMP-2 functions downstream of Src in parallel with the Wnt pathway in early embryogenesis of C. elegans.
The following hmp-2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the hmp-2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OCa335793 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001265497.2 , NM_001265497.1 | |
| Accession Version | NM_001265497.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2037bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-10-17 | |
| Organism | Caenorhabditis elegans | |
| Product | Beta-catenin-like protein hmp-2 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003279). On Sep 4, 2019 this sequence version replaced NM_001265497.1. | |
1 | ATGCTTCTTC ACTCTACCAA CTCTTATTCG ATATTCACTG ACCATGAAGT CGAAACTCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001252426.1 |
| CDS | 15..2051 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001265497.2 |
1 | ATGCTTCTTC ACTCTACCAA CTCTTATTCG ATATTCACTG ACCATGAAGT CGAAACTCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OCa335793 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001265497.2 , NM_001265497.1 | |
| Accession Version | NM_001265497.1 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2037bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-04-08 | |
| Organism | Caenorhabditis elegans | |
| Product | Beta-catenin-like protein hmp-2 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003279). COMPLETENESS: incomplete on both ends. | |
1 | ATGCTTCTTC ACTCTACCAA CTCTTATTCG ATATTCACTG ACCATGAAGT CGAAACTCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001252426.1 |
| CDS | 1..2037 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001265497.1 |
1 | ATGCTTCTTC ACTCTACCAA CTCTTATTCG ATATTCACTG ACCATGAAGT CGAAACTCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OCa336963 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001265496.1 , NM_001265496.2 | |
| Accession Version | NM_001265496.1 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2115bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-04-08 | |
| Organism | Caenorhabditis elegans | |
| Product | Beta-catenin-like protein hmp-2 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003279). COMPLETENESS: incomplete on both ends. | |
1 | ATGCGATTAT TCTCATATTT GGACGGTTGC GGTACCAAAA ATAGAGGAAT TTATCGTAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001252425.1 |
| CDS | 1..2115 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001265496.1 |
1 | ATGCGATTAT TCTCATATTT GGACGGTTGC GGTACCAAAA ATAGAGGAAT TTATCGTAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OCa336963 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001265496.1 , NM_001265496.2 | |
| Accession Version | NM_001265496.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2115bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-10-17 | |
| Organism | Caenorhabditis elegans | |
| Product | Beta-catenin-like protein hmp-2 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003279). On Sep 4, 2019 this sequence version replaced NM_001265496.1. COMPLETENESS: incomplete on the 5' end. | |
1 | ATGCGATTAT TCTCATATTT GGACGGTTGC GGTACCAAAA ATAGAGGAAT TTATCGTAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001252425.1 |
| CDS | 1..2115 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001265496.2 |
1 | ATGCGATTAT TCTCATATTT GGACGGTTGC GGTACCAAAA ATAGAGGAAT TTATCGTAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |