HMOX1 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	HMOX1
Entrez Gene ID	513221
Full Name	heme oxygenase 1
Synonyms	HO-1
General protein information	Preferred Names heme oxygenase 1 Names heme oxygenase 1 heme oxygenase (decycling) 1 heme oxygenase (decyclizing) 1
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001014912.1	NP_001014912.1	heme oxygenase 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	HMOX1	NP_001014912.1
Mus musculus (house mouse)	Hmox1	NP_034572.1
Homo sapiens (human)	HMOX1	NP_002124.1
Rattus norvegicus (Norway rat)	Hmox1	NP_036712.1
Xenopus tropicalis (tropical clawed frog)	hmox1	XP_002934766.1
Pan troglodytes (chimpanzee)	HMOX1	XP_525579.2
Canis lupus familiaris (dog)	HMOX1	NP_001181898.1
	HMOX1	XP_001113241.2
Gallus gallus (chicken)	HMOX1	NP_990675.1
Danio rerio (zebrafish)	hmox1a	NP_001120988.1

Gene Ontology
Bibliography

Related articles in PubMed

Heme Oxygenase-1 Suppresses Bovine Viral Diarrhoea Virus Replication in vitro.
Zhang C, Pu F, Zhang A, Xu L, Li N, Yan Y, Gao J, Liu H, Zhang G, Goodfellow IG, Zhou EM, Xiao S
Scientific reports515575(2015 Oct)

Immunohistochemical expression of nuclear factor erythroid-2-related factor 2 and heme oxygenase 1 in normal bovine lung and bovine lung infected with Mannheimia haemolytica.
Moussa AT, Singh B, Al-Dissi AN
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire79(2)81-6(2015 Apr)

Induction of HO-1 and redox signaling in endothelial cells by advanced glycation end products: a role for Nrf2 in vascular protection in diabetes.
He M, Siow RC, Sugden D, Gao L, Cheng X, Mann GE
Nutrition, metabolism, and cardiovascular diseases : NMCD21(4)277-85(2011 Apr)

Human sickle cell blood modulates endothelial heme oxygenase activity: effects on vascular adhesion and reactivity.
Bains SK, Foresti R, Howard J, Atwal S, Green CJ, Motterlini R
Arteriosclerosis, thrombosis, and vascular biology30(2)305-12(2010 Feb)

Heme oxygenase-1 induction modulates hypoxic pulmonary vasoconstriction through upregulation of ecSOD.
Ahmad M, Zhao X, Kelly MR, Kandhi S, Perez O, Abraham NG, Wolin MS
American journal of physiology. Heart and circulatory physiology297(4)H1453-61(2009 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the data were consistent with HO-1 acting as an anti-viral factor and these findings suggested that induction of HO-1 may be a useful prevention and treatment strategy against BVDV infection.
Title: Heme Oxygenase-1 Suppresses Bovine Viral Diarrhoea Virus Replication in vitro.

These findings suggest that bronchiolar epithelial cells and macrophages up-regulate Nrf2 expression early in the course of infection, which results in increased expression of HO-1 within these cells.
Title: Immunohistochemical expression of nuclear factor erythroid-2-related factor 2 and heme oxygenase 1 in normal bovine lung and bovine lung infected with Mannheimia haemolytica.

investigation of molecular mechanisms of microvascular complications in diabetes/hyperglycemia: regulation of HO-1 gene expression in aortic endothelial cells by advanced glycation end products
Title: Induction of HO-1 and redox signaling in endothelial cells by advanced glycation end products: a role for Nrf2 in vascular protection in diabetes.

Sickle blood increases endothelial heme oxygenase activity.
Title: Human sickle cell blood modulates endothelial heme oxygenase activity: effects on vascular adhesion and reactivity.

Heme oxygenase-1 induction modulates hypoxic pulmonary vasoconstriction through upregulation of ecSOD/SOD3.
Title: Heme oxygenase-1 induction modulates hypoxic pulmonary vasoconstriction through upregulation of ecSOD.

The following HMOX1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HMOX1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa41731	NM_001014912.1 Latest version!	Bos taurus heme oxygenase 1 (HMOX1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HMOX1 ( NM_001014912.1 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001014912.1 Bos taurus heme oxygenase 1 (HMOX1), mRNA.

Price & Availability↑

CloneID	OBa41731
Clone ID Related Accession (Same CDS sequence)	NM_001014912.1
Accession Version	NM_001014912.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 870bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Bos taurus(cattle)
Product	heme oxygenase 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BT020968.1. On Apr 11, 2005 this sequence version replaced XM_590873.1. ##Evidence-Data-START## Transcript exon combination :: BT020968.1, BC102105.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145413, SAMN03145414 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCGCC CGCAGCCCGA CAGCAGCATG CCCCAGGATT TGTCAGAGGC CCTGAAGGAG 
GCCACCAAGG AGGTGCACAC CCAGGCGGAG AATGCAGAGT TCATGAAGAA CTTTCAGAAG 
GGTGAGCTGA CCCAAGAAGG TTTTAAGCTG GTGATGGCGT CTTTGTACCA CATCTATGTG 
GCCCTGGAGG AGGAGATCGA ACGCAACAAG GAGAACCCCG TCTACACTCC CCTCTACTTC 
CCAGAGGAGC TGCACCGCCG GGCCTCCCTG GAGCAGGACA TGGCCTTCTG GTACGGGCCC 
CGCTGGCAGG AGGCCATCCC CTACACGCAG GCCACCAAGC GCTATGTTCA GCGACTCCAG 
GAGGTGGGGC GCACCGAGCC CGAACTGCTG GTGGCCCATG CCTACACCCG CTACCTGGGA 
GACCTGTCTG GGGGCCAAGT TCTCAAGAAG ATTGCTCAGA AGGCCCTGAA TCTGCCCAGC 
TCCGGGGAGG GCCTGGCCTT CTTCACTTTC CCCAATATCG CCAGTGCCAC CAAGTTCAAG 
CAGCTGTACC GCTCCCGCAT GAACACTCTG GAGATGACCC CTGAGGTCCG GCAGAGGGTC 
CTGGATGAGG CCAAGACCGC CTTCCTGCTC AACATCCAGC TGTTTGAGGA GTTGCAGGGC 
CTGCTGACCC AGAAGGCCAA GGACCATGAT CCCTTGCAGG CACCAGAGCT TCACAGGCGA 
GCCGGCAGCA AGGTGCAAGA CTTGGCTCCC ACCAAGGCGT CCAGGGGGAA GCCCCAGCCC 
AGCGTCCTCT CCCAGGCACC TCTCCTGCGA TGGGTCCTCA CACTCAGCTT TCTGGTGGCC 
ACGGTCGCTG TGGGGCTTTA CGCCATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001014912.1
CDS	92..961
Translation	MERPQPDSSMPQDLSEALKEATKEVHTQAENAEFMKNFQKGELTQEGFKLVMASLYHIYVALEEEIERNKENPVYTPLYFPEELHRRASLEQDMAFWYGPRWQEAIPYTQATKRYVQRLQEVGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALNLPSSGEGLAFFTFPNIASATKFKQLYRSRMNTLEMTPEVRQRVLDEAKTAFLLNIQLFEELQGLLTQKAKDHDPLQAPELHRRAGSKVQDLAPTKASRGKPQPSVLSQAPLLRWVLTLSFLVATVAVGLYAM

Target ORF information:

RefSeq Version	NM_001014912.1
Organism	Bos taurus(cattle)
Definition	Bos taurus heme oxygenase 1 (HMOX1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001014912.1

ORF Insert Sequence:

ATGGAGCGCC CGCAGCCCGA CAGCAGCATG CCCCAGGATT TGTCAGAGGC CCTGAAGGAG 
GCCACCAAGG AGGTGCACAC CCAGGCGGAG AATGCAGAGT TCATGAAGAA CTTTCAGAAG 
GGTGAGCTGA CCCAAGAAGG TTTTAAGCTG GTGATGGCGT CTTTGTACCA CATCTATGTG 
GCCCTGGAGG AGGAGATCGA ACGCAACAAG GAGAACCCCG TCTACACTCC CCTCTACTTC 
CCAGAGGAGC TGCACCGCCG GGCCTCCCTG GAGCAGGACA TGGCCTTCTG GTACGGGCCC 
CGCTGGCAGG AGGCCATCCC CTACACGCAG GCCACCAAGC GCTATGTTCA GCGACTCCAG 
GAGGTGGGGC GCACCGAGCC CGAACTGCTG GTGGCCCATG CCTACACCCG CTACCTGGGA 
GACCTGTCTG GGGGCCAAGT TCTCAAGAAG ATTGCTCAGA AGGCCCTGAA TCTGCCCAGC 
TCCGGGGAGG GCCTGGCCTT CTTCACTTTC CCCAATATCG CCAGTGCCAC CAAGTTCAAG 
CAGCTGTACC GCTCCCGCAT GAACACTCTG GAGATGACCC CTGAGGTCCG GCAGAGGGTC 
CTGGATGAGG CCAAGACCGC CTTCCTGCTC AACATCCAGC TGTTTGAGGA GTTGCAGGGC 
CTGCTGACCC AGAAGGCCAA GGACCATGAT CCCTTGCAGG CACCAGAGCT TCACAGGCGA 
GCCGGCAGCA AGGTGCAAGA CTTGGCTCCC ACCAAGGCGT CCAGGGGGAA GCCCCAGCCC 
AGCGTCCTCT CCCAGGCACC TCTCCTGCGA TGGGTCCTCA CACTCAGCTT TCTGGTGGCC 
ACGGTCGCTG TGGGGCTTTA CGCCATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Heme Oxygenase-1 Suppresses Bovine Viral Diarrhoea Virus Replication in vitro.
Scientific reports515575(2015 Oct)
Zhang C,Pu F,Zhang A,Xu L,Li N,Yan Y,Gao J,Liu H,Zhang G,Goodfellow IG,Zhou EM,Xiao S

Immunohistochemical expression of nuclear factor erythroid-2-related factor 2 and heme oxygenase 1 in normal bovine lung and bovine lung infected with Mannheimia haemolytica.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire79(2)81-6(2015 Apr)
Moussa AT,Singh B,Al-Dissi AN

Induction of HO-1 and redox signaling in endothelial cells by advanced glycation end products: a role for Nrf2 in vascular protection in diabetes.
Nutrition, metabolism, and cardiovascular diseases : NMCD21(4)277-85(2011 Apr)
He M,Siow RC,Sugden D,Gao L,Cheng X,Mann GE

Human sickle cell blood modulates endothelial heme oxygenase activity: effects on vascular adhesion and reactivity.
Arteriosclerosis, thrombosis, and vascular biology30(2)305-12(2010 Feb)
Bains SK,Foresti R,Howard J,Atwal S,Green CJ,Motterlini R

Heme oxygenase-1 induction modulates hypoxic pulmonary vasoconstriction through upregulation of ecSOD.
American journal of physiology. Heart and circulatory physiology297(4)H1453-61(2009 Oct)
Ahmad M,Zhao X,Kelly MR,Kandhi S,Perez O,Abraham NG,Wolin MS