CGA cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	CGA
Entrez Gene ID	280749
Full Name	glycoprotein hormones, alpha polypeptide
General protein information	Preferred Names glycoprotein hormones, alpha polypeptide Names glycoprotein hormones alpha chain FSH-alpha LSH-alpha TSH-alpha anterior pituitary glycoprotein hormones common subunit alpha chorionic gonadotropin, alpha chain follicle-stimulating hormone alpha chain follitropin alpha chain luteinizing hormone alpha chain lutropin alpha chain thyroid-stimulating hormone alpha chain thyrotropin alpha chain
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_173901.3	NP_776326.1	glycoprotein hormones alpha chain precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CGA	XP_003950934.1
Canis lupus familiaris (dog)	CGA	NP_001002988.1
Rattus norvegicus (Norway rat)	Cga	NP_446370.2
Xenopus tropicalis (tropical clawed frog)	cga	XP_002933966.1
Homo sapiens (human)	CGA	NP_001239312.1
	CGA	XP_001090917.1
Mus musculus (house mouse)	Cga	NP_034019.1
Bos taurus (cattle)	CGA	NP_776326.1
Gallus gallus (chicken)	CGA	NP_001264950.1
Danio rerio (zebrafish)	cga	NP_991250.1

Gene Ontology
Bibliography

Related articles in PubMed

Effects of TSH on the function of human umbilical vein endothelial cells.
Tian L, Zhang L, Liu J, Guo T, Gao C, Ni J
Journal of molecular endocrinology52(2)215-22(2014 Apr)

Interaction between neurotrophin 4 and gonadotrophin in bovine oviducts.
Sun Y, Zhang J, Li C, Wang D, Ma Y, Sun Y, Liu Z, Wang C, Zhou X
Theriogenology78(1)39-48(2012 Jul)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

Characterization and nucleotide sequence of the gene for the common alpha subunit of the bovine pituitary glycoprotein hormones.
Goodwin RG, Moncman CL, Rottman FM, Nilson JH
Nucleic acids research11(19)6873-82(1983 Oct)

Nucleotide sequence of cloned complementary deoxyribonucleic acid for the alpha subunit of bovine pituitary glycoprotein hormones.
Erwin CR, Croyle ML, Donelson JE, Maurer RA
Biochemistry22(20)4856-60(1983 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results demonstrate that elevated TSH can promote endothelial dysfunction by altering gene expression in human umbilical vein endothelial cells.
Title: Effects of TSH on the function of human umbilical vein endothelial cells.

Neurotrophin 4 may have a role in regulating the function of bovine oviducts by interacting with gonadotrophins.
Title: Interaction between neurotrophin 4 and gonadotrophin in bovine oviducts.

The following CGA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CGA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa22638	NM_173901.3 Latest version!	Bos taurus glycoprotein hormones, alpha polypeptide (CGA), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CGA ( NM_173901.3 ) cDNA ORF clone, Bos taurus(cattle) -> NP_776326.1 Bos taurus glycoprotein hormones, alpha polypeptide (CGA), mRNA.

Price & Availability↑

CloneID	OBa22638
Clone ID Related Accession (Same CDS sequence)	NM_173901.3
Accession Version	NM_173901.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 363bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-22
Organism	Bos taurus(cattle)
Product	glycoprotein hormones alpha chain precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from NKLS02000009.1. On Mar 11, 2011 this sequence version replaced NM_173901.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: CB533125.1, CB443237.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145418, SAMN03145419 [ECO:0000348] ##Evidence-Data-END##

ATGGATTACT ACAGAAAATA TGCAGCTGTC ATTCTGGCCA TTTTGTCTCT GTTTCTGCAA 
ATTCTCCATT CCTTTCCTGA TGGAGAGTTT ACAATGCAGG GCTGTCCTGA ATGCAAGCTA 
AAAGAAAACA AATACTTCTC CAAGCCAGAT GCTCCAATCT ATCAGTGCAT GGGGTGCTGC 
TTCTCCAGGG CATACCCCAC TCCAGCGAGG TCTAAGAAGA CAATGTTGGT CCCCAAGAAC 
ATCACCTCGG AAGCTACATG CTGTGTGGCC AAAGCATTTA CCAAGGCCAC AGTGATGGGA 
AATGTCAGAG TGGAGAACCA CACCGAGTGC CACTGCAGCA CTTGTTATTA TCACAAATCC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776326.1
CDS	106..468
Translation	MDYYRKYAAVILAILSLFLQILHSFPDGEFTMQGCPECKLKENKYFSKPDAPIYQCMGCCFSRAYPTPARSKKTMLVPKNITSEATCCVAKAFTKATVMGNVRVENHTECHCSTCYYHKS

Target ORF information:

RefSeq Version	NM_173901.3
Organism	Bos taurus(cattle)
Definition	Bos taurus glycoprotein hormones, alpha polypeptide (CGA), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173901.3

ORF Insert Sequence:

ATGGATTACT ACAGAAAATA TGCAGCTGTC ATTCTGGCCA TTTTGTCTCT GTTTCTGCAA 
ATTCTCCATT CCTTTCCTGA TGGAGAGTTT ACAATGCAGG GCTGTCCTGA ATGCAAGCTA 
AAAGAAAACA AATACTTCTC CAAGCCAGAT GCTCCAATCT ATCAGTGCAT GGGGTGCTGC 
TTCTCCAGGG CATACCCCAC TCCAGCGAGG TCTAAGAAGA CAATGTTGGT CCCCAAGAAC 
ATCACCTCGG AAGCTACATG CTGTGTGGCC AAAGCATTTA CCAAGGCCAC AGTGATGGGA 
AATGTCAGAG TGGAGAACCA CACCGAGTGC CACTGCAGCA CTTGTTATTA TCACAAATCC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Effects of TSH on the function of human umbilical vein endothelial cells.
Journal of molecular endocrinology52(2)215-22(2014 Apr)
Tian L,Zhang L,Liu J,Guo T,Gao C,Ni J

Interaction between neurotrophin 4 and gonadotrophin in bovine oviducts.
Theriogenology78(1)39-48(2012 Jul)
Sun Y,Zhang J,Li C,Wang D,Ma Y,Sun Y,Liu Z,Wang C,Zhou X

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

Characterization and nucleotide sequence of the gene for the common alpha subunit of the bovine pituitary glycoprotein hormones.
Nucleic acids research11(19)6873-82(1983 Oct)
Goodwin RG,Moncman CL,Rottman FM,Nilson JH

Nucleotide sequence of cloned complementary deoxyribonucleic acid for the alpha subunit of bovine pituitary glycoprotein hormones.
Biochemistry22(20)4856-60(1983 Sep)
Erwin CR,Croyle ML,Donelson JE,Maurer RA