| Gene Symbol | HEMC |
| Entrez Gene ID | 830724 |
| Full Name | hydroxymethylbilane synthase |
| Synonyms | F8L15.10,F8L15_10,PORPHOBILINOGEN DEAMINASE,RUG1,RUGOSA 1,hydroxymethylbilane synthase |
| Gene Type | protein-coding |
| Organism | Arabidopsis thaliana(thale cress) |
ORF » Species Summary » Arabidopsis thaliana » HEMC cDNA ORF clone
| Gene Symbol | HEMC |
| Entrez Gene ID | 830724 |
| Full Name | hydroxymethylbilane synthase |
| Synonyms | F8L15.10,F8L15_10,PORPHOBILINOGEN DEAMINASE,RUG1,RUGOSA 1,hydroxymethylbilane synthase |
| Gene Type | protein-coding |
| Organism | Arabidopsis thaliana(thale cress) |
| mRNA | Protein | Name |
|---|---|---|
| NM_120911.4 | NP_196445.1 | hydroxymethylbilane synthase |
| Mus musculus (house mouse) | Hmbs | NP_038579.2 |
| Gallus gallus (chicken) | HMBS | XP_417846.2 |
| Saccharomyces cerevisiae (baker's yeast) | HEM3 | NP_010076.1 |
| Schizosaccharomyces pombe (fission yeast) | hem3 | NP_001018179.1 |
| Arabidopsis thaliana (thale cress) | HEMC | NP_196445.1 |
| Canis lupus familiaris (dog) | HMBS | XP_546491.2 |
| Oryza sativa (rice) | Os02g0168800 | NP_001046017.1 |
| HMBS | XP_001101764.1 | |
| Bos taurus (cattle) | HMBS | NP_001039672.1 |
| Rattus norvegicus (Norway rat) | Hmbs | NP_037300.2 |
| Danio rerio (zebrafish) | hmbsa | NP_957448.1 |
| Drosophila melanogaster (fruit fly) | l(3)02640 | NP_612103.1 |
| Neurospora crassa | NCU10292 | XP_001728039.1 |
| Homo sapiens (human) | HMBS | NP_000181.2 |
| Danio rerio (zebrafish) | hmbsb | NP_001019559.1 |
| Kluyveromyces lactis | KLLA0C15147g | XP_452879.1 |
| Magnaporthe oryzae (rice blast fungus) | MGG_04860 | XP_003712340.1 |
| Xenopus tropicalis (tropical clawed frog) | hmbs | NP_001005635.1 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP011080 | XP_564464.3 |
| Eremothecium gossypii | AGOS_ABL107C | NP_982840.1 |
Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.
Tabata S, Kaneko T, Nakamura Y, Kotani H, Kato T, Asamizu E, Miyajima N, Sasamoto S, Kimura T, Hosouchi T, Kawashima K, Kohara M, Matsumoto M, Matsuno A, Muraki A, Nakayama S, Nakazaki N, Naruo K, Okumura S, Shinpo S, Takeuchi C, Wada T, Watanabe A, Yamada M, Yasuda M, Sato S, de la Bastide M, Huang E, Spiegel L, Gnoj L, O'Shaughnessy A, Preston R, Habermann K, Murray J, Johnson D, Rohlfing T, Nelson J, Stoneking T, Pepin K, Spieth J, Sekhon M, Armstrong J, Becker M, Belter E, Cordum H, Cordes M, Courtney L, Courtney W, Dante M, Du H, Edwards J, Fryman J, Haakensen B, Lamar E, Latreille P, Leonard S, Meyer R, Mulvaney E, Ozersky P, Riley A, Strowmatt C, Wagner-McPherson C, Wollam A, Yoakum M, Bell M, Dedhia N, Parnell L, Shah R, Rodriguez M, See LH, Vil D, Baker J, Kirchoff K, Toth K, King L, Bahret A, Miller B, Marra M, Martienssen R, McCombie WR, Wilson RK, Murphy G, Bancroft I, Volckaert G, Wambutt R, D?sterh?ft A, Stiekema W, Pohl T, Entian KD, Terryn N, Hartley N, Bent E, Johnson S, Langham SA, McCullagh B, Robben J, Grymonprez B, Zimmermann W, Ramsperger U, Wedler H, Balke K, Wedler E, Peters S, van Staveren M, Dirkse W, Mooijman P, Lankhorst RK, Weitzenegger T, Bothe G, Rose M, Hauf J, Berneiser S, Hempel S, Feldpausch M, Lamberth S, Villarroel R, Gielen J, Ardiles W, Bents O, Lemcke K, Kolesov G, Mayer K, Rudd S, Schoof H, Schueller C, Zaccaria P, Mewes HW, Bevan M, Fransz P, , ,
Nature408(6814)823-6(2000 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The interactions observed between the two pyrrole rings of the HEMC dipyrromethane cofactor and the active-site residues are highly specific and are most likely to represent the catalytically relevant binding mode.
Title: Insights into the mechanism of pyrrole polymerization catalysed by porphobilinogen deaminase: high-resolution X-ray studies of the Arabidopsis thaliana enzyme.
Porphobilinogen deaminase deficiency alters vegetative and reproductive development and causes lesions in Arabidopsis.
Title: PORPHOBILINOGEN DEAMINASE deficiency alters vegetative and reproductive development and causes lesions in Arabidopsis.
Crystallization and preliminary X-ray characterization of the tetrapyrrole-biosynthetic enzyme porphobilinogen deaminase from Arabidopsis thaliana. [porphobilinogen deaminase]
Title: Crystallization and preliminary X-ray characterization of the tetrapyrrole-biosynthetic enzyme porphobilinogen deaminase from Arabidopsis thaliana.
The following HEMC gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HEMC cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OAb17894 | |
| Clone ID Related Accession (Same CDS sequence) | NM_120911.4 | |
| Accession Version | NM_120911.4 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1149bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-02-13 | |
| Organism | Arabidopsis thaliana(thale cress) | |
| Product | hydroxymethylbilane synthase | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by TAIR and Araport. This record is derived from an annotated genomic sequence (NC_003076). On Sep 12, 2016 this sequence version replaced NM_120911.3. | |
1 | ATGGATATTG CTTCGTCATC TCTCTCACAA GCTCACAAAG TCGTTCTCAC GCGTCAACCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_196445.1 |
| CDS | 231..1379 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_120911.4 |
1 | ATGGATATTG CTTCGTCATC TCTCTCACAA GCTCACAAAG TCGTTCTCAC GCGTCAACCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. |