TNFSF12/TWEAK, rFc Chimera, Mouse
TNFSF12/TWEAK, RFc Chimera, Mouse

Immobilized Mouse TNFRSF12A, hFc Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for TNFSF12/TWEAK, rFc Chimera, Mouse, Rabbit Fc Tag with the EC50 of 0.28 μg/ml determined by ELISA.

TNFSF12/TWEAK, RFc Chimera, Mouse

TNFSF12/TWEAK, rFc Chimera, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

TNFSF12/TWEAK, RFc Chimera, Mouse

TNFSF12/TWEAK, rFc Chimera, Mouse, Rabbit Fc Tag immobilized on CM5 Chip can bind Mouse TNFRSF12A, hFc Tag with an affinity constant of 0.12 nM as determined in SPR assay (Biacore T200).

TNFSF12/TWEAK, rFc Chimera, Mouse

Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a well known multifunctional cytokine extensively distributed in cell types and tissues. Accumulating evidence has shown that TWEAK binding to the receptor factor-inducible 14 (Fn14) participates in diverse pathologic processes including cell proliferation and death, angiogenesis, carcinogenesis and inflammation.
Z06384
¥72,752.00

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Product Introduction
Species Mouse
Protein Construction
Rabbit Fc TNFSF12/TWEAK (Ser46-His249)_x000D_
Accession # O54907
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 48.95 kDa
Apparent Molecular Weight Due to furin cleavage and glycosylation, the protein migrates to 40-50 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • TNFSF12/TWEAK, RFc Chimera, Mouse
    • TNFSF12/TWEAK, RFc Chimera, Mouse

    Immobilized Mouse TNFRSF12A, hFc Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for TNFSF12/TWEAK, rFc Chimera, Mouse, Rabbit Fc Tag with the EC50 of 0.28 μg/ml determined by ELISA.

  • TNFSF12/TWEAK, RFc Chimera, Mouse
    • TNFSF12/TWEAK, RFc Chimera, Mouse

    TNFSF12/TWEAK, rFc Chimera, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • TNFSF12/TWEAK, RFc Chimera, Mouse
    • TNFSF12/TWEAK, RFc Chimera, Mouse

    TNFSF12/TWEAK, rFc Chimera, Mouse, Rabbit Fc Tag immobilized on CM5 Chip can bind Mouse TNFRSF12A, hFc Tag with an affinity constant of 0.12 nM as determined in SPR assay (Biacore T200).


Background
Target Background Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a well known multifunctional cytokine extensively distributed in cell types and tissues. Accumulating evidence has shown that TWEAK binding to the receptor factor-inducible 14 (Fn14) participates in diverse pathologic processes including cell proliferation and death, angiogenesis, carcinogenesis and inflammation.
Synonyms TNFSF12; APO3 ligand; APO3L; DR3LG; UNQ181/PRO207; TWEAK; MGC129581

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.