SOST/Sclerostin, His, Mouse
SOST/Sclerostin, His, Mouse

Immobilized SOST/Sclerostin, His, Mouse, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Human LRP-6, mFc Tag with the EC50 of 15.0ng/ml determined by ELISA.

SOST/Sclerostin, His, Mouse

SOST/Sclerostin, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SOST/Sclerostin, His, Mouse

SOST, also known as sclerostin, is a member of the cerberus/DAN family, a group of secreted glycoproteins characterized by a cysteine-knot motif. SOST is negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
Z06358
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Product Introduction
Species Mouse
Protein Construction
His SOST/Sclerostin (Gln24-Tyr211)_x000D_
Accession # Q99P68
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 22 kDa
Apparent Molecular Weight Due to glycosylation,the protein migrates to 30-40 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • SOST/Sclerostin, His, Mouse
    • SOST/Sclerostin, His, Mouse

    Immobilized SOST/Sclerostin, His, Mouse, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Human LRP-6, mFc Tag with the EC50 of 15.0ng/ml determined by ELISA.

  • SOST/Sclerostin, His, Mouse
    • SOST/Sclerostin, His, Mouse

    SOST/Sclerostin, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background SOST, also known as sclerostin, is a member of the cerberus/DAN family, a group of secreted glycoproteins characterized by a cysteine-knot motif. SOST is negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
Synonyms sclerostin; SOST; VBCHsclerosteosis; CDD; DAND6; SOST1; VBCH

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.