IL-23R, His, Mouse
IL-23R, His, Mouse

The purity of IL-23R, His, Mouse is greater than 95% as determined by SEC-HPLC.

IL-23R, His, Mouse

IL-23R, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

IL-23R, His, Mouse

IL-23R, His, Mouse on CM5 Chip can bind Mouse IL-23 alpha&IL-12 beta, His Tag with an affinity constant of 6.31 nM as determined in SPR assay (Biacore T200).

IL-23R, His, Mouse

Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R beta 1) and the IL-23-specific receptor subunit (IL-23 R).This receptor associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade.
Z06207
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Product Introduction
Species Mouse
Protein Construction
IL-23R (Gly24-Gly374)_x000D_
Accession # Q8K4B4		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 41.48 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 60-80 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • IL-23R, His, Mouse
    • IL-23R, His, Mouse

    The purity of IL-23R, His, Mouse is greater than 95% as determined by SEC-HPLC.

  • IL-23R, His, Mouse
    • IL-23R, His, Mouse

    IL-23R, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • IL-23R, His, Mouse
    • IL-23R, His, Mouse

    IL-23R, His, Mouse on CM5 Chip can bind Mouse IL-23 alpha&IL-12 beta, His Tag with an affinity constant of 6.31 nM as determined in SPR assay (Biacore T200).


Background
Target Background Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R beta 1) and the IL-23-specific receptor subunit (IL-23 R).This receptor associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade.
Synonyms IBD17; IL-23 R; IL-23 receptor; Il23r; Interleukin-23 receptor

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.