DDR1, His, Mouse
DDR1, His, Mouse

The purity of DDR1, His, Mouse is greater than 95% as determined by SEC-HPLC.

DDR1, His, Mouse

DDR1, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

DDR1, His, Mouse

Discoidin domain receptor1 (DDR1) is a collagen activated receptor tyrosine kinase and an attractive anti-fibrotic target. Its expression is mainly limited to epithelial cells located in several organs including skin, kidney, liver and lung. DDR1's biology is elusive, with unknown downstream activation pathways; however, it may act as a mediator of the stromal-epithelial interaction, potentially controlling the activation state of the resident quiescent fibroblasts.
Z06083
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Product Introduction
Species Mouse
Protein Construction
DDR1 (Asp22-Ala415)_x000D_
Accession # Q03146-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 44.9 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 60-65 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • DDR1, His, Mouse
    • DDR1, His, Mouse

    The purity of DDR1, His, Mouse is greater than 95% as determined by SEC-HPLC.

  • DDR1, His, Mouse
    • DDR1, His, Mouse

    DDR1, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Discoidin domain receptor1 (DDR1) is a collagen activated receptor tyrosine kinase and an attractive anti-fibrotic target. Its expression is mainly limited to epithelial cells located in several organs including skin, kidney, liver and lung. DDR1's biology is elusive, with unknown downstream activation pathways; however, it may act as a mediator of the stromal-epithelial interaction, potentially controlling the activation state of the resident quiescent fibroblasts.
Synonyms HGK2; MCK-10; CAK; EDDR1; NEP; NTRK4; PTK3A; RTK6; TRKE; DDR1; CD167; EDDR1; PTK3; CD167a; DDR; EC 2.7.10; EC 2.7.10.1; ENTRK4

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.