TSLPR hFc Chimera, Human
TSLPR HFc Chimera, Human

Immobilized Human TSLP (R127A, R130A), His Tag at 2 μg/ml(100 μl/well) on the plate. Dose response curve for TSLPR hFc Chimera, Human, hFc Tag with the EC50 of 4.1ng/ml determined by ELISA.

TSLPR HFc Chimera, Human

Immobilized TSLPR hFc Chimera, Human, hFc Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Anti-TSLPR Antibody, hFc Tag with the EC50 of 26.1ng/ml determined by ELISA.

TSLPR HFc Chimera, Human

The purity of TSLPR hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

TSLPR HFc Chimera, Human

TSLPR hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

TSLPR HFc Chimera, Human

Human TSLP, His Tag captured on CM5 Chip via Anti-His Antibody can bind TSLPR hFc Chimera, Human, hFc Tag with an affinity constant of 1.04 nM as determined in SPR assay (Biacore T200).

TSLPR hFc Chimera, Human

Thymic stromal lymphopoietin (TSLP) is an interleukin-7 (IL-7) like cytokine, which plays an important role in the regulation of immune responses to allergens. TSLP binds to a heterodimeric receptor complex composed of the IL-7 receptor alpha chain (IL-7Ralpha) and the TSLP receptor (TSLPR, also known as CRLF2).
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Product Introduction
Species Human
Protein Construction
TSLPR (Gly25-Lys231)_x000D_
Accession # Q9HC73-1		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 50.8 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 60-75 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • TSLPR HFc Chimera, Human
    • TSLPR HFc Chimera, Human

    Immobilized Human TSLP (R127A, R130A), His Tag at 2 μg/ml(100 μl/well) on the plate. Dose response curve for TSLPR hFc Chimera, Human, hFc Tag with the EC50 of 4.1ng/ml determined by ELISA.

  • TSLPR HFc Chimera, Human
    • TSLPR HFc Chimera, Human

    Immobilized TSLPR hFc Chimera, Human, hFc Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Anti-TSLPR Antibody, hFc Tag with the EC50 of 26.1ng/ml determined by ELISA.

  • TSLPR HFc Chimera, Human
    • TSLPR HFc Chimera, Human

    The purity of TSLPR hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

  • TSLPR HFc Chimera, Human
    • TSLPR HFc Chimera, Human

    TSLPR hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • TSLPR HFc Chimera, Human
    • TSLPR HFc Chimera, Human

    Human TSLP, His Tag captured on CM5 Chip via Anti-His Antibody can bind TSLPR hFc Chimera, Human, hFc Tag with an affinity constant of 1.04 nM as determined in SPR assay (Biacore T200).


Background
Target Background Thymic stromal lymphopoietin (TSLP) is an interleukin-7 (IL-7) like cytokine, which plays an important role in the regulation of immune responses to allergens. TSLP binds to a heterodimeric receptor complex composed of the IL-7 receptor alpha chain (IL-7Ralpha) and the TSLP receptor (TSLPR, also known as CRLF2).
Synonyms TSLP receptor; TSLPR; CRL2; CRLF2Y; CRLF2; IL-XR; p2RY8/CRLF2 fusion; CRLF2

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.