TRAIL/TNFRSF10, Human

TRAIL/TNFRSF10, Human

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can initiate the apoptosis pathway by binding to its associated death receptors DR4 and DR5. The activation of the TRAIL pathway in inducing tumor-selective apoptosis leads to the development of TRAIL-based cancer therapies, which include recombinant forms of TRAIL, TRAIL receptor agonists, and other therapeutic agents.
Z05916
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Product Introduction
Species Human
Protein Construction
TRAIL/TNFRSF10 (Val114-Gly281)_x000D_
Accession # NP_003801.1
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System E.coli
Theoretical Molecular Weight 19.6 kDa
Apparent Molecular Weight The protein has a predicted MW of 19.6 kDa same as Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in 50mM Tris, 300mM NaCl (pH 7.2).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Background
Target Background Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can initiate the apoptosis pathway by binding to its associated death receptors DR4 and DR5. The activation of the TRAIL pathway in inducing tumor-selective apoptosis leads to the development of TRAIL-based cancer therapies, which include recombinant forms of TRAIL, TRAIL receptor agonists, and other therapeutic agents.
Synonyms Apo-2L; TRAIL; CD253; TNFSF10; Apo-2 ligand; APO2L; TL2

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.