OX40 Ligand/TNFSF4 hFc Chimera, Human
OX40 Ligand/TNFSF4 HFc Chimera, Human

Immobilized Human OX40, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for OX40 Ligand/TNFSF4 hFc Chimera, Human, hFc Tag with the EC50 of 6.7ng/ml determined by ELISA.

OX40 Ligand/TNFSF4 HFc Chimera, Human

The purity of OX40 Ligand/TNFSF4 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

OX40 Ligand/TNFSF4 HFc Chimera, Human

OX40 Ligand/TNFSF4 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

OX40 Ligand/TNFSF4 HFc Chimera, Human

Human OX40, His-Avi Tag captured on CM5 Chip via Anti-His Antibody can bind OX40 Ligand/TNFSF4 hFc Chimera, Human, hFc Tag with an affinity constant of 4.17 nM as determined in SPR assay (Biacore T200).

OX40 Ligand/TNFSF4 hFc Chimera, Human

Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L),which belongs to the tumor necrosis factor family. It is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation.
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Product Introduction
Species Human
Protein Construction
hFc OX40 Ligand/TNFSF4 (Gln51-Leu183)_x000D_
Accession # P23510-1
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 40.95 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 50-60 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • OX40 Ligand/TNFSF4 HFc Chimera, Human
    • OX40 Ligand/TNFSF4 HFc Chimera, Human

    Immobilized Human OX40, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for OX40 Ligand/TNFSF4 hFc Chimera, Human, hFc Tag with the EC50 of 6.7ng/ml determined by ELISA.

  • OX40 Ligand/TNFSF4 HFc Chimera, Human
    • OX40 Ligand/TNFSF4 HFc Chimera, Human

    The purity of OX40 Ligand/TNFSF4 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

  • OX40 Ligand/TNFSF4 HFc Chimera, Human
    • OX40 Ligand/TNFSF4 HFc Chimera, Human

    OX40 Ligand/TNFSF4 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • OX40 Ligand/TNFSF4 HFc Chimera, Human
    • OX40 Ligand/TNFSF4 HFc Chimera, Human

    Human OX40, His-Avi Tag captured on CM5 Chip via Anti-His Antibody can bind OX40 Ligand/TNFSF4 hFc Chimera, Human, hFc Tag with an affinity constant of 4.17 nM as determined in SPR assay (Biacore T200).


Background
Target Background Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L),which belongs to the tumor necrosis factor family. It is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation.
Synonyms OX40L; OX-40L; OX4OL; CD252; TNFSF4; OX40 Ligand; CD134 ligand; CD134L; TXGP1; Glycoprotein Gp34

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.