Oncostatin M/OSM, His, Human
Oncostatin M/OSM, His, Human

Measured in a cell proliferation assay using TF-1 human erythroleukemic cells.The ED50 for this effect is 0.3-1 ng/mL (QC Test).

Oncostatin M/OSM, His, Human

The purity of Oncostatin M/OSM, His, Human is greater than 95% as determined by SEC-HPLC.

Oncostatin M/OSM, His, Human

Oncostatin M/OSM, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Oncostatin M/OSM, His, Human

Human LIF R, hFc Tag captured on CM5 Chip via Protein A can bind Oncostatin M/OSM, His, Human, His Tag with an affinity constant of 0.884 μM as determined in SPR assay (Biacore T200).

Oncostatin M/OSM, His, Human

OSM is a pleiotropic cytokine that initiates its biological activities by binding to specific cell surface receptors. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.
Z05714
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Product Introduction
Species Human
Protein Construction
Oncostatin M/OSM (Ala26-Arg221)_x000D_
Accession # P13725		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 0.1 EU per μg by the LAL method.
Biological Activity Measured in a cell proliferation assay using TF­1 human erythroleukemic cells. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 23.24 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 30-40 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • Oncostatin M/OSM, His, Human
    • Oncostatin M/OSM, His, Human

    Measured in a cell proliferation assay using TF-1 human erythroleukemic cells.The ED50 for this effect is 0.3-1 ng/mL (QC Test).

  • Oncostatin M/OSM, His, Human
    • Oncostatin M/OSM, His, Human

    The purity of Oncostatin M/OSM, His, Human is greater than 95% as determined by SEC-HPLC.

  • Oncostatin M/OSM, His, Human
    • Oncostatin M/OSM, His, Human

    Oncostatin M/OSM, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • Oncostatin M/OSM, His, Human
    • Oncostatin M/OSM, His, Human

    Human LIF R, hFc Tag captured on CM5 Chip via Protein A can bind Oncostatin M/OSM, His, Human, His Tag with an affinity constant of 0.884 μM as determined in SPR assay (Biacore T200).


Background
Target Background OSM is a pleiotropic cytokine that initiates its biological activities by binding to specific cell surface receptors. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.
Synonyms Oncostatin M; OSM; MGC20461

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.