NRG1 Beta 1 hFc Chimera, Human
NRG1 Beta 1 HFc Chimera, Human

Immobilized Human Her4, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for NRG1 Beta 1 hFc Chimera, Human, hFc Tag with the EC50 of 10.6ng/ml determined by ELISA.

NRG1 Beta 1 HFc Chimera, Human

Immobilized Human Her3, His Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for NRG1 Beta 1 hFc Chimera, Human, hFc Tag with the EC50 of 15.4ng/ml determined by ELISA.

NRG1 Beta 1 HFc Chimera, Human

The purity of NRG1 Beta 1 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

NRG1 Beta 1 HFc Chimera, Human

NRG1 Beta 1 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

NRG1 Beta 1 hFc Chimera, Human

Neuregulin-1 (NRG-1) is a ligand of the epidermal growth factor receptor (erbB), and its interaction involves activation of the glutamatergic N-methyl-Daspartate receptor, which increases the expression of the β2 subunit of the γ- aminobutyric acid receptor and subunits of the nicotinic acetylcholine receptor.
Z05710
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Product Introduction
Species Human
Protein Construction
hFc NRG1 Beta 1 (Ser2-Lys246)_x000D_
Accession # Q02297-6
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 54.00 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 70-80 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • NRG1 Beta 1 HFc Chimera, Human
    • NRG1 Beta 1 HFc Chimera, Human

    Immobilized Human Her4, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for NRG1 Beta 1 hFc Chimera, Human, hFc Tag with the EC50 of 10.6ng/ml determined by ELISA.

  • NRG1 Beta 1 HFc Chimera, Human
    • NRG1 Beta 1 HFc Chimera, Human

    Immobilized Human Her3, His Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for NRG1 Beta 1 hFc Chimera, Human, hFc Tag with the EC50 of 15.4ng/ml determined by ELISA.

  • NRG1 Beta 1 HFc Chimera, Human
    • NRG1 Beta 1 HFc Chimera, Human

    The purity of NRG1 Beta 1 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

  • NRG1 Beta 1 HFc Chimera, Human
    • NRG1 Beta 1 HFc Chimera, Human

    NRG1 Beta 1 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Neuregulin-1 (NRG-1) is a ligand of the epidermal growth factor receptor (erbB), and its interaction involves activation of the glutamatergic N-methyl-Daspartate receptor, which increases the expression of the β2 subunit of the γ- aminobutyric acid receptor and subunits of the nicotinic acetylcholine receptor.
Synonyms Pro-NRG1; NRG1; GGF; HGL; HRGA; NDF; SMDF; Beta1; Beta1A

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.