MUC18/CD146, His, Human
MUC18/CD146, His, Human

Immobilized MUC18/CD146, His, Human, His Tag at 1 μg /ml(100 μl/well) on the plate. Dose response curve for Anti-Muc18 Antibody, hFc Tag with the EC50 of 12.5ng/ml determined by ELISA.

MUC18/CD146, His, Human

The purity of MUC18/CD146, His, Human is greater than 95% as determined by SEC-HPLC.

MUC18/CD146, His, Human

MUC18/CD146, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

MUC18/CD146, His, Human

METCAM/MUC18 is an integral membrane cell adhesion molecule (CAM) in the Ig-like gene super-family. It can carry out common functions of CAMs which is to perform intercellular interactions and interaction of cell with extracellular matrix in tumor microenvironment, to interact with various signaling pathways and to regulate general behaviors of cells.The above positive correlation is fortuitous; actually METCAM/MUC18 acts as a tumor and metastasis suppressor for the ovarian carcinoma cells.
Z05662
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Product Introduction
Species Human
Protein Construction
MUC18/CD146 (Val24-Gly559)_x000D_
Accession # P43121		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 60.8 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 80-110 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • MUC18/CD146, His, Human
    • MUC18/CD146, His, Human

    Immobilized MUC18/CD146, His, Human, His Tag at 1 μg /ml(100 μl/well) on the plate. Dose response curve for Anti-Muc18 Antibody, hFc Tag with the EC50 of 12.5ng/ml determined by ELISA.

  • MUC18/CD146, His, Human
    • MUC18/CD146, His, Human

    The purity of MUC18/CD146, His, Human is greater than 95% as determined by SEC-HPLC.

  • MUC18/CD146, His, Human
    • MUC18/CD146, His, Human

    MUC18/CD146, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background METCAM/MUC18 is an integral membrane cell adhesion molecule (CAM) in the Ig-like gene super-family. It can carry out common functions of CAMs which is to perform intercellular interactions and interaction of cell with extracellular matrix in tumor microenvironment, to interact with various signaling pathways and to regulate general behaviors of cells.The above positive correlation is fortuitous; actually METCAM/MUC18 acts as a tumor and metastasis suppressor for the ovarian carcinoma cells.
Synonyms Gicerin; CD146; MCAM; MUC18

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.