Latexin, His, Human
Latexin, His, Human

The purity of Latexin, His, Human is greater than 95% as determined by SEC-HPLC.

Latexin, His, Human

Latexin, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Latexin, His, Human

Latexin, the endogenous protein inhibitor of the A/B subfamily of metallocarboxypeptidases, is expressed in small nociceptive neurons in sensory ganglia and in a subset of neurons in the telencephalon. Recently, the latexin (Lxn) gene was identified as a potential tumor suppressor in several types of solid tumors and lymphoma, and Lxn expression was found to be absent or downregulated in leukemic cells.
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Product Introduction
Species Human
Protein Construction
His Latexin (Glu2-Glu222)_x000D_
Accession # AAH05346
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its ability to inhibit carboxypeptidase A1 cleavage of the colorimetric peptide substrate Ac­PheThiaphe­OH in the presence of 5,5'Dithio­bis (2­nitrobenzoic acid) (DTNB). Test result meets the standard.
Expression System E.coli
Theoretical Molecular Weight 27.16 kDa
Apparent Molecular Weight The protein migrates to 30-35 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • Latexin, His, Human
    • Latexin, His, Human

    The purity of Latexin, His, Human is greater than 95% as determined by SEC-HPLC.

  • Latexin, His, Human
    • Latexin, His, Human

    Latexin, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Latexin, the endogenous protein inhibitor of the A/B subfamily of metallocarboxypeptidases, is expressed in small nociceptive neurons in sensory ganglia and in a subset of neurons in the telencephalon. Recently, the latexin (Lxn) gene was identified as a potential tumor suppressor in several types of solid tumors and lymphoma, and Lxn expression was found to be absent or downregulated in leukemic cells.
Synonyms ECI; MUM; TCI; LXN

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.