Endoglin/CD105, His & Avi, Human
Endoglin/CD105, His & Avi, Human

Immobilized Endoglin/CD105, His & Avi, Human, His Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-Endoglin Antibody, hFc Tag with the EC50 of 8.1ng/ml determined by ELISA.

Endoglin/CD105, His & Avi, Human

The purity of Endoglin/CD105, His & Avi, Human is greater than 90% as determined by SEC-HPLC.

Endoglin/CD105, His & Avi, Human

Endoglin/CD105, His & Avi, Human on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.

Endoglin/CD105, His & Avi, Human

Endoglin (CD105) is a 90 kDa type I transmembrane glycoprotein of the zona pellucida (ZP) family of proteins. Endoglin is a vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development. May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis.
Z05238
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Product Introduction
Species Human
Protein Construction
Endoglin/CD105 (Glu26-Gly586)
Accession # P17813-1		 His Avi
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 63.7 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 70-82 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • Endoglin/CD105, His & Avi, Human
    • Endoglin/CD105, His & Avi, Human

    Immobilized Endoglin/CD105, His & Avi, Human, His Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-Endoglin Antibody, hFc Tag with the EC50 of 8.1ng/ml determined by ELISA.

  • Endoglin/CD105, His & Avi, Human
    • Endoglin/CD105, His & Avi, Human

    The purity of Endoglin/CD105, His & Avi, Human is greater than 90% as determined by SEC-HPLC.

  • Endoglin/CD105, His & Avi, Human
    • Endoglin/CD105, His & Avi, Human

    Endoglin/CD105, His & Avi, Human on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.


Background
Target Background Endoglin (CD105) is a 90 kDa type I transmembrane glycoprotein of the zona pellucida (ZP) family of proteins. Endoglin is a vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development. May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis.
Synonyms CD105; Endoglin; ENG; ORW; ORW1; END; HHT1

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.