LILRB2/CD85d/ILT4 hFc Chimera, Cynomolgus
LILRB2/CD85d/ILT4 HFc Chimera, Cynomolgus

LILRB2/CD85d/ILT4 hFc Chimera, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

LILRB2/CD85d/ILT4 HFc Chimera, Cynomolgus

LILRB2/CD85d/ILT4 hFc Chimera, Cynomolgus, hFc Tag captured on CM5 Chip via Protein A can bind Cynomolgus HLA-G&B2M&Peptide (RIIPRHLQL) Tetramer, His Tag with an affinity constant of 42.50 nM as determined in SPR assay (Biacore T200).

LILRB2/CD85d/ILT4 hFc Chimera, Cynomolgus

The immunoglobulin-like transcript (ILT) comprise a family of activating and inhibitory type immunoreceptors whose genes are located in the same locus that encodes killer cell Ig-like receptors (KIR). ILT4, also known as LIR-2 and LILRB2, is a type I transmembrane protein expressed primarily on monocytes and dendritic cells (DC). LILRB2 is a receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles.
Z04858
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Product Introduction
Species Cynomolgus
Protein Construction
LILRB2/CD85d/ILT4 (Gly24-Arg457)
Accession # XP_015297203.1		 hFc
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Loaded LILRB2/CD85d/ILT4 hFc Chimera, Cynomolgus on ProA-Biosensor can bind Cynomolgus HLAG&B2M&Peptide (RIIPRHLQL) Tetramer Protein, His Tag in BLI assay (Gator® Prime). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 71.68 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 80-90 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • LILRB2/CD85d/ILT4 HFc Chimera, Cynomolgus
    • LILRB2/CD85d/ILT4 HFc Chimera, Cynomolgus

    LILRB2/CD85d/ILT4 hFc Chimera, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • LILRB2/CD85d/ILT4 HFc Chimera, Cynomolgus
    • LILRB2/CD85d/ILT4 HFc Chimera, Cynomolgus

    LILRB2/CD85d/ILT4 hFc Chimera, Cynomolgus, hFc Tag captured on CM5 Chip via Protein A can bind Cynomolgus HLA-G&B2M&Peptide (RIIPRHLQL) Tetramer, His Tag with an affinity constant of 42.50 nM as determined in SPR assay (Biacore T200).


Background
Target Background The immunoglobulin-like transcript (ILT) comprise a family of activating and inhibitory type immunoreceptors whose genes are located in the same locus that encodes killer cell Ig-like receptors (KIR). ILT4, also known as LIR-2 and LILRB2, is a type I transmembrane protein expressed primarily on monocytes and dendritic cells (DC). LILRB2 is a receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles.
Synonyms CD85d; ILT4; ILT-4; ILT4CD85d; LILRB2; LIR2; MIR10

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.