B7-H7/HHLA2, His, Cynomolgus
B7-H7/HHLA2, His, Cynomolgus

The purity of B7-H7/HHLA2, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

B7-H7/HHLA2, His, Cynomolgus

B7-H7/HHLA2, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

B7-H7/HHLA2, His, Cynomolgus

B7-H7/HHLA2, His, Cynomolgus, His Tag captured on CM5 Chip via anti-his antibody can bind Human CD28H, hFc Tag with an affinity constant of 7.86 nM as determined in SPR assay (Biacore T200).

B7-H7/HHLA2, His, Cynomolgus

B7-H7, also known as HHLA2 (HERV-H LTR-associating 2), is a member of the B7 family of immune regulatory proteins.Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
Z04743
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Product Introduction
Species Cynomolgus
Protein Construction
B7-H7/HHLA2 (Ile21-Asn345)
Accession # XP_005548285.2		 His
N-term C-term
Purity > 95% as determined by Bis-­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Loaded B7-H7/HHLA2, His, Cynomolgus on Anti­-His­-Biosensor can bind Human CD28H, hFc Tag in BLI assay (Gator® Prime). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 38.31 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • B7-H7/HHLA2, His, Cynomolgus
    • B7-H7/HHLA2, His, Cynomolgus

    The purity of B7-H7/HHLA2, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

  • B7-H7/HHLA2, His, Cynomolgus
    • B7-H7/HHLA2, His, Cynomolgus

    B7-H7/HHLA2, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • B7-H7/HHLA2, His, Cynomolgus
    • B7-H7/HHLA2, His, Cynomolgus

    B7-H7/HHLA2, His, Cynomolgus, His Tag captured on CM5 Chip via anti-his antibody can bind Human CD28H, hFc Tag with an affinity constant of 7.86 nM as determined in SPR assay (Biacore T200).


Background
Target Background B7-H7, also known as HHLA2 (HERV-H LTR-associating 2), is a member of the B7 family of immune regulatory proteins.Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
Synonyms B7H7; B7-H7; HHLA2; B7 Homolog 7

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.