PDGF R beta/CD140b, His, Canine
PDGF R Beta/CD140b, His, Canine

The purity of PDGF R beta/CD140b, His, Canine is greater than 95% as determined by SEC-HPLC.

PDGF R Beta/CD140b, His, Canine

PDGF R beta/CD140b, His, Canine on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

PDGF R Beta/CD140b, His, Canine

Human PDGFB, His Tag immobilized on CM5 Chip can bind PDGF R beta/CD140b, His, Canine, His Tag with an affinity constant of 0.203 μM as determined in SPR assay (Biacore T200).

PDGF R beta/CD140b, His, Canine

PDGF is a major serum mitogen that can exist as a homo or hetero-dimeric protein consisting of disulfide-linked PDGF-A and PDGF-B chains. The PDGF-AA,PDGF-BB and PDGF-AB isoforms have been shown to bind to two distinct cell surface PDGF receptors with different affinities. Where as PDGF R alpha binds all three PDGF isoforms with high affinity, PDGF R beta binds PDGF-BB only with high-affinity. PDGF R plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites.
Z04712
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Product Introduction
Species Canine
Protein Construction
PDGF R beta/CD140b (Gly32-Val532)
Accession # Q6QNF3		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 57.25 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 70-100 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • PDGF R Beta/CD140b, His, Canine
    • PDGF R Beta/CD140b, His, Canine

    The purity of PDGF R beta/CD140b, His, Canine is greater than 95% as determined by SEC-HPLC.

  • PDGF R Beta/CD140b, His, Canine
    • PDGF R Beta/CD140b, His, Canine

    PDGF R beta/CD140b, His, Canine on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • PDGF R Beta/CD140b, His, Canine
    • PDGF R Beta/CD140b, His, Canine

    Human PDGFB, His Tag immobilized on CM5 Chip can bind PDGF R beta/CD140b, His, Canine, His Tag with an affinity constant of 0.203 μM as determined in SPR assay (Biacore T200).


Background
Target Background PDGF is a major serum mitogen that can exist as a homo or hetero-dimeric protein consisting of disulfide-linked PDGF-A and PDGF-B chains. The PDGF-AA,PDGF-BB and PDGF-AB isoforms have been shown to bind to two distinct cell surface PDGF receptors with different affinities. Where as PDGF R alpha binds all three PDGF isoforms with high affinity, PDGF R beta binds PDGF-BB only with high-affinity. PDGF R plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites.
Synonyms JTK12; PDGF R beta; PDGFR; PDGFR1; PDGFRB; CD140B; PDGFR-2; PDGFR-β; PDGF R β

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.