Tim-3/HAVCR2[Biotin], His & Avi, Human
Tim-3/HAVCR2[Biotin], His & Avi, Human

Immobilized Anti-Tim-3 Antibody, hFc Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Tim-3/HAVCR2[Biotin], His & Avi, Human, His Tag with the EC50 of 12.5ng/ml determined by ELISA.

Tim-3/HAVCR2[Biotin], His & Avi, Human

The purity of Tim-3/HAVCR2[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

Tim-3/HAVCR2[Biotin], His & Avi, Human

Tim-3/HAVCR2[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Tim-3/HAVCR2[Biotin], His & Avi, Human

Hepatitis A virus cellular receptor 2 (HAVCR2), also known as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), is a protein that in humans is encoded by the HAVCR2 gene.TIM3 is an immune checkpoint and together with other inhibitory receptors including programmed cell death protein 1 (PD-1) and lymphocyte activation gene 3 protein (LAG3) mediate the CD8 T-cell exhaustion. TIM3 has also been shown as a CD4 Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.
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Product Introduction
Species Human
Protein Construction
TIM-3/HAVCR2 (Ser22-Arg200)
Accession # Q8TDQ0-1		 His Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 22.8 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 45-50 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • Tim-3/HAVCR2[Biotin], His & Avi, Human
    • Tim-3/HAVCR2[Biotin], His & Avi, Human

    Immobilized Anti-Tim-3 Antibody, hFc Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Tim-3/HAVCR2[Biotin], His & Avi, Human, His Tag with the EC50 of 12.5ng/ml determined by ELISA.

  • Tim-3/HAVCR2[Biotin], His & Avi, Human
    • Tim-3/HAVCR2[Biotin], His & Avi, Human

    The purity of Tim-3/HAVCR2[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

  • Tim-3/HAVCR2[Biotin], His & Avi, Human
    • Tim-3/HAVCR2[Biotin], His & Avi, Human

    Tim-3/HAVCR2[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Hepatitis A virus cellular receptor 2 (HAVCR2), also known as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), is a protein that in humans is encoded by the HAVCR2 gene.TIM3 is an immune checkpoint and together with other inhibitory receptors including programmed cell death protein 1 (PD-1) and lymphocyte activation gene 3 protein (LAG3) mediate the CD8 T-cell exhaustion. TIM3 has also been shown as a CD4 Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.
Synonyms CD366; TIM3; TIM-3; TIMD-3; TIM 3; FLJ14428; HAVCR2; KIM3

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.