SOST/Sclerostin[Biotin], His & Avi, Human
SOST/Sclerostin[Biotin], His & Avi, Human

Immobilized SOST/Sclerostin[Biotin], His & Avi, Human, His Tag at 5 μg/ml (100 μl/well) on the streptavidin precoated plate(5 μg/ml). Dose response curve for Human LRP-6, mFc Tag with the EC50 of 10.1 ng/ml determined by ELISA.

SOST/Sclerostin[Biotin], His & Avi, Human

SOST/Sclerostin[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SOST/Sclerostin[Biotin], His & Avi, Human

Immobilized Anti-SOST Antibody, hFc Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for SOST/Sclerostin[Biotin], His & Avi, Human , His Tag with the EC50 of 9.6ng/ml determined by ELISA.

SOST/Sclerostin[Biotin], His & Avi, Human

SOST, also known as sclerostin, is a member of the cerberus/DAN family, a group of secreted glycoproteins characterized by a cysteine-knot motif. SOST is negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
Z04617
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Product Introduction
Species Human
Protein Construction
Avi His SOST/Sclerostin (Gln24-Tyr213)
Accession # Q9BQB4-1
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 24.2 kDa
Apparent Molecular Weight Due to glycosylation,the protein migrates to 28-40 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • SOST/Sclerostin[Biotin], His & Avi, Human
    • SOST/Sclerostin[Biotin], His & Avi, Human

    Immobilized SOST/Sclerostin[Biotin], His & Avi, Human, His Tag at 5 μg/ml (100 μl/well) on the streptavidin precoated plate(5 μg/ml). Dose response curve for Human LRP-6, mFc Tag with the EC50 of 10.1 ng/ml determined by ELISA.

  • SOST/Sclerostin[Biotin], His & Avi, Human
    • SOST/Sclerostin[Biotin], His & Avi, Human

    SOST/Sclerostin[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • SOST/Sclerostin[Biotin], His & Avi, Human
    • SOST/Sclerostin[Biotin], His & Avi, Human

    Immobilized Anti-SOST Antibody, hFc Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for SOST/Sclerostin[Biotin], His & Avi, Human , His Tag with the EC50 of 9.6ng/ml determined by ELISA.


Background
Target Background SOST, also known as sclerostin, is a member of the cerberus/DAN family, a group of secreted glycoproteins characterized by a cysteine-knot motif. SOST is negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
Synonyms sclerostin; SOST; VBCHsclerosteosis; CDD; DAND6; SOST1; VBCH

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.