Immobilized M-CSF R/CSF1R/CD115[Biotin], His & Avi, Human, His Tag at 0.5 μg/ml(100 μl/well) on the streptavidin precoated plate(5μg/ml). Dose response curve for Anti-M-CSF R Antibody, hFc Tag with the EC50 of 4.2ng/ml determined by ELISA.
The purity of M-CSF R/CSF1R/CD115[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.
M-CSF R/CSF1R/CD115[Biotin], His & Avi, Human, His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
M-CSF R/CSF1R/CD115[Biotin], His & Avi, Human, His & Avi, Human on CM5 Chip can bind Human M-CSF, No Tag with an affinity constant of 0.81 μM as determined in SPR assay (Biacore T200).
M-CSF R/CSF1R/CD115[Biotin], His & Avi, Human
CSF1R also known as M-CSF receptor, the product of the c-fms proto-oncogene, is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region.CSF1R is tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes.
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