HMGB1 [Biotin], His, Human
HMGB1 [Biotin], His, Human

The purity of HMGB1 [Biotin], His, Human is greater than 95% as determined by SEC-HPLC.

HMGB1 [Biotin], His, Human

HMGB1 [Biotin], His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

HMGB1 [Biotin], His, Human

Human AGER, His Tag immobilized on CM5 Chip can bind HMGB1 [Biotin], His, Human, His Tag with an affinity constant of 2.60 μM as determined in SPR assay (Biacore T200).

HMGB1 [Biotin], His, Human

High-mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that promotes inflammation when released extracellularly after cellular activation, stress, damage or death. HMGB1 operates as one of the most intriguing molecules in inflammatory disorders via recently elucidated signal and molecular transport mechanisms. Treatments based on antagonists specifically targeting extracellular HMGB1 have generated encouraging results in a wide number of experimental models of infectious and sterile inflammation.
Z04479
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Product Introduction
Species Human
Protein Construction
HMGB1 (Met1-Glu215)
Accession # P09429-1		 His
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per ug by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 26 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 32-36 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • HMGB1 [Biotin], His, Human
    • HMGB1 [Biotin], His, Human

    The purity of HMGB1 [Biotin], His, Human is greater than 95% as determined by SEC-HPLC.

  • HMGB1 [Biotin], His, Human
    • HMGB1 [Biotin], His, Human

    HMGB1 [Biotin], His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • HMGB1 [Biotin], His, Human
    • HMGB1 [Biotin], His, Human

    Human AGER, His Tag immobilized on CM5 Chip can bind HMGB1 [Biotin], His, Human, His Tag with an affinity constant of 2.60 μM as determined in SPR assay (Biacore T200).


Background
Target Background High-mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that promotes inflammation when released extracellularly after cellular activation, stress, damage or death. HMGB1 operates as one of the most intriguing molecules in inflammatory disorders via recently elucidated signal and molecular transport mechanisms. Treatments based on antagonists specifically targeting extracellular HMGB1 have generated encouraging results in a wide number of experimental models of infectious and sterile inflammation.
Synonyms HMGB1; HMG1; HMG3; SBP-1; HMG-1

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.