Serial dilutions of Anti-GDF15 Antibody were added into Human GDF15, His Tag : GFRAL/GFR alpha-like[Biotin], His & Avi, Human, His Tag binding reactioins. The half maximal inhibitiory concentration(IC50) is 40.8 ng/ml.
Immobilized Human GDF15, hFc Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for GFRAL/GFR alpha-like[Biotin], His & Avi, Human, His-Avi Tag with the EC50 of 84.2 ng/ml determined by ELISA.
The purity of GFRAL/GFR alpha-like[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.
GFRAL/GFR alpha-like[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.
GFRAL/GFR alpha-like[Biotin], His & Avi, Human
GFR alpha -like (GDNF receptor-alpha-like) is a distant member of the GDNFR family of proteins. Mature human GFR alpha-like is a 376 amino acid (aa) type I transmembrane protein. It contains a 333 aa extracellular domain, a 20 aa transmembrane domain and a 23 aa cytoplasmic domain.GFRAL is a brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses.
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