VEGF R1/FLT-1, His&Avi, Human
VEGF R1/FLT-1, His&Avi, Human

VEGF R1/FLT-1, His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

VEGF R1/FLT-1, His&Avi, Human

Immobilized VEGF R1/FLT-1, His & Avi, Human at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Human VEGF121, His Tag with the EC50 of 24.4 ng/ml determined by ELISA.

VEGF R1/FLT-1, His&Avi, Human

Biotinylated Human VEGF165, His Tag captured on CM5 Chip via streptavidin can bind VEGF R1/FLT-1, His&Avi, Human, His Tag with an affinity constant of 1.36 pM as determined in SPR assay (Biacore T200).

VEGF R1/FLT-1, His&Avi, Human

VEGFR1 (vascular endothelial growth factor receptor 1), also called Flt-1 (Fms-like tyrosine kinase), is a 180 kDa type I transmembrane glycoprotein in the class III subfamily of receptor tyrosine kinases (RTKs).yrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells.
Z03964
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Product Introduction
Species Human
Protein Construction
VEGF R1/FLT-1 (Ser27-Asn756)
Accession # P17948-1		 His Avi
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 85.1 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 100-120 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from a 0.22 μm filtered solution in PBS, (pH 7.4).
Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH2O more than 100 μg/ml.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • VEGF R1/FLT-1, His&Avi, Human
    • VEGF R1/FLT-1, His&Avi, Human

    VEGF R1/FLT-1, His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • VEGF R1/FLT-1, His&Avi, Human
    • VEGF R1/FLT-1, His&Avi, Human

    Immobilized VEGF R1/FLT-1, His & Avi, Human at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Human VEGF121, His Tag with the EC50 of 24.4 ng/ml determined by ELISA.

  • VEGF R1/FLT-1, His&Avi, Human
    • VEGF R1/FLT-1, His&Avi, Human

    Biotinylated Human VEGF165, His Tag captured on CM5 Chip via streptavidin can bind VEGF R1/FLT-1, His&Avi, Human, His Tag with an affinity constant of 1.36 pM as determined in SPR assay (Biacore T200).


Background
Target Background Vascular endothelial growth factor receptor 1(VEGFR1), also known as Flt-1, is a type I transmembrane glycoprotein of receptor tyrosine kinases (RTKs) family. VEGFR1 acts as a cell-surface receptor for VEGFA, VEGFB and PGF. It plays an important role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration and cancer cell invasion.
Synonyms FLT; FLT1; Flt-1; FRT; VEGF R1; VEGFR1

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.