GUCY2C/Guanylyl cyclase C, His, Cynomolgus
GUCY2C/Guanylyl Cyclase C, His, Cynomolgus

Immobilized GUCY2C/Guanylyl cyclase C, His, Cynomolgus at 5 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-GUCY2C Antibody, hFc Tag with the EC50 of 34.0 ng/ml determined by ELISA.

GUCY2C/Guanylyl Cyclase C, His, Cynomolgus

GUCY2C/Guanylyl cyclase C, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

GUCY2C/Guanylyl Cyclase C, His, Cynomolgus

The purity of GUCY2C/Guanylyl cyclase C, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

GUCY2C/Guanylyl cyclase C, His, Cynomolgus

Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier function. GUCY2C may represent a new target for anti-obesity pharmacotherapy.
Z03914
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Product Introduction
Species Cynomolgus
Protein Construction
GUCY2C/Guanylyl cyclase C (Ser24-Gln430)
Accession # XP_005570270.1		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 47.2 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 60-75 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from a 0.22 μm filtered solution in PBS, pH 7.4 .
Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH2O more than 100 μg/ml.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles. Recommend to aliquot the protein into smaller quantities for optimal storage.

Examples
  • GUCY2C/Guanylyl Cyclase C, His, Cynomolgus
    • GUCY2C/Guanylyl Cyclase C, His, Cynomolgus

    Immobilized GUCY2C/Guanylyl cyclase C, His, Cynomolgus at 5 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-GUCY2C Antibody, hFc Tag with the EC50 of 34.0 ng/ml determined by ELISA.

  • GUCY2C/Guanylyl Cyclase C, His, Cynomolgus
    • GUCY2C/Guanylyl Cyclase C, His, Cynomolgus

    GUCY2C/Guanylyl cyclase C, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • GUCY2C/Guanylyl Cyclase C, His, Cynomolgus
    • GUCY2C/Guanylyl Cyclase C, His, Cynomolgus

    The purity of GUCY2C/Guanylyl cyclase C, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.


Background
Target Background Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier function. GUCY2C may represent a new target for anti-obesity pharmacotherapy.
Synonyms Guanylyl cyclase C; GC-C; STAR; GUCY2C; GUC2C; STA receptor; DIAR6; EC 4.6.1; GCC; GUC2CEC 4.6.1.2; MUCIL

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.