Her2/ErbB2 Domain 4[Biotin], His & Avi, Human
Her2/ErbB2 Domain 4[Biotin], His & Avi, Human

Her2/ErbB2 Domain 4[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Her2/ErbB2 Domain 4[Biotin], His & Avi, Human

The purity of Her2/ErbB2 Domain 4[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

Her2/ErbB2 Domain 4[Biotin], His & Avi, Human

Immobilized Her2/ErbB2 Domain 4[Biotin], His & Avi, Human at 1 μg/ml (100 μl/well) on the streptavidin precoated plate(5 μg/ml). Dose response curve for Anti-HER2 Antibody, hFc Tag with the EC50 of 7.5 ng/ml determined by ELISA.

Her2/ErbB2 Domain 4[Biotin], His & Avi, Human

ErbB2, also called Neu and Her2 (human epidermal growth factor receptor 2), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors.Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane.
Z03902
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Product Introduction
Species Human
Protein Construction
Her2/ErbB2 Domain 4 (Pro489-Cys630)
Accession # P04626-1		 His Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 18.5 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 28-40 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from a 0.22 μm filtered solution in PBS, pH 7.4.
Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH2O more than 100 μg/ml.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • Her2/ErbB2 Domain 4[Biotin], His & Avi, Human
    • Her2/ErbB2 Domain 4[Biotin], His & Avi, Human

    Her2/ErbB2 Domain 4[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • Her2/ErbB2 Domain 4[Biotin], His & Avi, Human
    • Her2/ErbB2 Domain 4[Biotin], His & Avi, Human

    The purity of Her2/ErbB2 Domain 4[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

  • Her2/ErbB2 Domain 4[Biotin], His & Avi, Human
    • Her2/ErbB2 Domain 4[Biotin], His & Avi, Human

    Immobilized Her2/ErbB2 Domain 4[Biotin], His & Avi, Human at 1 μg/ml (100 μl/well) on the streptavidin precoated plate(5 μg/ml). Dose response curve for Anti-HER2 Antibody, hFc Tag with the EC50 of 7.5 ng/ml determined by ELISA.


Background
Target Background ErbB2, also called Neu and Her2 (human epidermal growth factor receptor 2), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors.Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane.
Synonyms CD340; EGFR2; ErbB2; HER2; HER-2; herstatin; MLN 19; MLN19; NGL; TKR1; ERBB2; NEU; ENV; ENVW; ERVWE1; HERV7Q; HERVW

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.