MSLN/Mesothelin(296-580) hFc Chimera, Human
MSLN/Mesothelin(296-580) HFc Chimera, Human

Immobilized Human CA125, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for MSLN/Mesothelin(296-580) hFc Chimera, Human, hFc Tag with the EC50 of 8.3 ng/ml determined by ELISA.

MSLN/Mesothelin(296-580) HFc Chimera, Human

MSLN/Mesothelin(296-580) hFc Chimera, Human on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.

MSLN/Mesothelin(296-580) HFc Chimera, Human

Immobilized MSLN/Mesothelin(296-580) hFc Chimera, Human at 0.5μg/ml(100μl/well) on the plate. Dose response curve for Biotinylated Anti-MSLN Antibody, hFc Tag with the EC50 of 44.2 ng/ml determined by ELISA.

MSLN/Mesothelin(296-580) hFc Chimera, Human

Mesothelin, also known as MSLN, is a protein that in humans is encoded by the MSLN gene.Cloning studies showed that the mesothelin gene encodes a precursor protein that is processed to yield mesothelin which is attached to the cell membrane by a glycophosphatidylinositol linkage and a 31-kDa shed fragment named megakaryocyte-potentiating factor (MPF). Although it has been proposed that mesothelin may be involved in cell adhesion, its biological function is not known.A knockout mouse line that lacks mesothelin reproduces and develops normally.
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Product Introduction
Species Human
Protein Construction
MSLN/Mesothelin (Glu296-Gly580)
Accession # Q13421-2		 hFc
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 59 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 68-78 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from a 0.22 μm filtered solution in PBS, pH 7.4.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • MSLN/Mesothelin(296-580) HFc Chimera, Human
    • MSLN/Mesothelin(296-580) HFc Chimera, Human

    Immobilized Human CA125, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for MSLN/Mesothelin(296-580) hFc Chimera, Human, hFc Tag with the EC50 of 8.3 ng/ml determined by ELISA.

  • MSLN/Mesothelin(296-580) HFc Chimera, Human
    • MSLN/Mesothelin(296-580) HFc Chimera, Human

    MSLN/Mesothelin(296-580) hFc Chimera, Human on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.

  • MSLN/Mesothelin(296-580) HFc Chimera, Human
    • MSLN/Mesothelin(296-580) HFc Chimera, Human

    Immobilized MSLN/Mesothelin(296-580) hFc Chimera, Human at 0.5μg/ml(100μl/well) on the plate. Dose response curve for Biotinylated Anti-MSLN Antibody, hFc Tag with the EC50 of 44.2 ng/ml determined by ELISA.


Background
Target Background Mesothelin, also known as MSLN, is encoded by the MSLN gene. It encodes a precursor protein of 71 kDa that is processed to a 31 kDa shed protein called megakaryocyte potentiating factor (MPF) and a 40 kDa fragment, mesothelin. MSLN is attached to the cell membrane by a glycosyl-phosphatidylinositol (GPI) anchor. It is a differentiation antigen which is highly expressed in several human cancers, including virtually all mesotheliomas and pancreatic adenocarcinomas.
Synonyms MSLN; CAK1; Mesothelin; MPF; MPFSMRP; SMR

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.