CEA, hFc, Human
CEA Fc Chimera, Human

Immobilized CEA Fc Chimera, Human (C555MFL310-32) at 1 μg/ml (100 μl/well) can bind Human CEA Antibody (1A5C3), Mouse with EC50=2.342 ng/ml when detected by M6 Goat Anti Mouse Fc. Background was subtracted from data points before curve fitting.

CEA Fc chimera, Human

Carcinoembryonic antigen (CEA) also known as Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), CD antigen CD66e, Meconium antigen 100, is an oncofetal glycoprotein that is normally expressed by mucosal cells. CEA is a member of the immunoglobulin (Ig) superfamily of proteins. CEA is a glycophosphatidylinositol- (GPI-) linked membrane-anchoring protein that is exposed to the cell surface that faces the extracellular matrix. The membrane-anchoring region of CEA can be cleaved by phospholipase C and phospholipase D. The cleaved products are soluble and circulating through blood vessels. Thus, CEA can be present as secreted and cell surface-anchored forms. CEA is functionally associated with cellular interaction, cell adhesion, immune response, anoikis resistance, and promotion of liver metastasis. CEA overexpression is associated with many types of cancers including gastrointestinal, respiratory, and genitourinary system and breast cancers.
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Product Introduction
Species Human
Protein Construction
CEA (Lys35-Ala685)
Accession # P06731		 hFc
N-term C-term
Purity > 95% as analyzed by SDS-PAGE
Endotoxin Level < 1 EU/μg of protein by gel clotting method
Biological Activity Immobilized CEA, hFc, Human at 1.0 μg/ml (100 μl/well) can bind Human CEA Antibody (1A5C3), Mouse with EC50=2.342 ng/ml when detected by M6 Goat Anti Mouse Fc.
Expression System CHO 3E7
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml.
Storage & Stability Upon receiving, this product remains stable for 6 months at lower than -70°C. Upon reconstitution, the product should be stable for 1 week at 4°C or for 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

Examples
  • CEA Fc Chimera, Human
    • CEA Fc Chimera, Human

    Immobilized CEA Fc Chimera, Human (C555MFL310-32) at 1 μg/ml (100 μl/well) can bind Human CEA Antibody (1A5C3), Mouse with EC50=2.342 ng/ml when detected by M6 Goat Anti Mouse Fc. Background was subtracted from data points before curve fitting.


Background
Target Background Carcinoembryonic antigen (CEA) also known as Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), CD antigen CD66e, Meconium antigen 100, is an oncofetal glycoprotein that is normally expressed by mucosal cells. CEA is a member of the immunoglobulin (Ig) superfamily of proteins. CEA is a glycophosphatidylinositol- (GPI-) linked membrane-anchoring protein that is exposed to the cell surface that faces the extracellular matrix. The membrane-anchoring region of CEA can be cleaved by phospholipase C and phospholipase D. The cleaved products are soluble and circulating through blood vessels. Thus, CEA can be present as secreted and cell surface-anchored forms. CEA is functionally associated with cellular interaction, cell adhesion, immune response, anoikis resistance, and promotion of liver metastasis. CEA overexpression is associated with many types of cancers including gastrointestinal, respiratory, and genitourinary system and breast cancers.
Synonyms CEACAM5; CD66e; Meconium antigen 100

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.