cer1.S cDNA ORF clone, Xenopus laevis(African clawed frog)

Gene
Clones
gRNAs

Summary

Gene Symbol	cer1.S
Entrez Gene ID	398060
Full Name	cerberus 1, DAN family BMP antagonist S homeolog
Synonyms	cer,cer-1,dand4,tCerberus,xcer-1,xcer1
General protein information	Preferred Names cerberus 1, DAN family BMP antagonist S homeolog Names cerberus cer1 cerberus 1, cysteine knot superfamily xcer
Gene Type	protein-coding
Organism	Xenopus laevis(African clawed frog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001088331.2	NP_001081800.1	cerberus precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Generating asymmetries in the early vertebrate embryo: the role of the Cerberus-like family.
Belo JA, Silva AC, Borges AC, Filipe M, Bento M, Gon?alves L, Vitorino M, Salgueiro AM, Texeira V, Tavares AT, Marques S
The International journal of developmental biology53(8-10)1399-407(2009)

Multiple functions of Cerberus cooperate to induce heart downstream of Nodal.
Foley AC, Korol O, Timmer AM, Mercola M
Developmental biology303(1)57-65(2007 Mar)

An atlas of differential gene expression during early Xenopus embryogenesis.
Pollet N, Muncke N, Verbeek B, Li Y, Fenger U, Delius H, Niehrs C
Mechanisms of development122(3)365-439(2005 Mar)

Neural induction in Xenopus: requirement for ectodermal and endomesodermal signals via Chordin, Noggin, beta-Catenin, and Cerberus.
Kuroda H, Wessely O, De Robertis EM
PLoS biology2(5)E92(2004 May)

Endogenous Cerberus activity is required for anterior head specification in Xenopus.
Silva AC, Filipe M, Kuerner KM, Steinbeisser H, Belo JA
Development (Cambridge, England)130(20)4943-53(2003 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Studies indicate that erberus prevents Nodal signaling in the anterior and right sides of the embryo.
Title: Generating asymmetries in the early vertebrate embryo: the role of the Cerberus-like family.

Cardiogenesis in mesoderm depends on Nodal-mediated induction of Cerberus in underlying endoderm.
Title: Multiple functions of Cerberus cooperate to induce heart downstream of Nodal.

Chordin, Noggin, beta-Catenin, and Cerberus have roles in neural induction in Xenopus
Title: Neural induction in Xenopus: requirement for ectodermal and endomesodermal signals via Chordin, Noggin, beta-Catenin, and Cerberus.

The following cer1.S gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the cer1.S cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OAf00976	NM_001088331.2 Latest version!	Xenopus laevis cerberus 1, DAN family BMP antagonist S homeolog (cer1.S), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

cer1.S ( NM_001088331.2 ) cDNA ORF clone, Xenopus laevis(African clawed frog) -> NP_001081800.1 Xenopus laevis cerberus 1, DAN family BMP antagonist S homeolog (cer1.S), mRNA.

Price & Availability↑

CloneID	OAf00976
Clone ID Related Accession (Same CDS sequence)	NM_001088331.2
Accession Version	NM_001088331.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 813bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Xenopus laevis(African clawed frog)
Product	cerberus precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U64831.1. On Sep 23, 2016 this sequence version replaced NM_001088331.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U64831.1, BC081277.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00012420, SAMN02851418 [ECO:0000348] ##Evidence-Data-END##

ATGTTACTAA ATGTACTCAG GATCTGTATT ATCGTCTGCC TTGTGAATGA TGGAGCAGGA 
AAACACTCAG AAGGACGAGA AAGGACAAAA ACATATTCAC TTAACAGCAG AGGTTACTTC 
AGAAAAGAAA GAGGAGCACG TAGGAGCAAG ATTCTGCTGG TGAATACTAA AGGTCTTGAT 
GAACCCCACA TTGGGCATGG TGATTTTGGC TTAGTAGCTG AACTATTTGA TTCCACCAGA 
ACACATACAA ACAGAAAAGA GCCAGACATG AACAAAGTCA AGCTTTTCTC AACAGTTGCC 
CATGGAAACA AAAGTGCAAG AAGAAAAGCT TACAATGGTT CTAGAAGGAA TATTTTTTCT 
CGCCGTTCTT TTGATAAAAG AAATACAGAG GTTACTGAAA AGCCTGGTGC CAAGATGTTC 
TGGAACAATT TTTTGGTTAA AATGAATGGA GCCCCACAGA ATACAAGCCA TGGCAGTAAA 
GCACAGGAAA TAATGAAAGA AGCTTGCAAA ACCTTGCCCT TCACTCAGAA TATTGTACAT 
GAAAACTGTG ACAGGATGGT GATACAGAAC AATCTGTGCT TTGGTAAATG CATCTCTCTC 
CATGTTCCAA ATCAGCAAGA TCGACGAAAT ACTTGTTCCC ATTGCTTGCC GTCCAAATTT 
ACCCTGAACC ACCTGACGCT GAATTGTACT GGATCTAAGA ATGTAGTAAA GGTTGTCATG 
ATGGTAGAGG AATGCACGTG TGAAGCTCAT AAGAGCAACT TCCACCAAAC TGCACAGTTT 
AACATGGATA CATCTACTAC CCTGCACCAT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001081800.1
CDS	66..878
Translation	MLLNVLRICIIVCLVNDGAGKHSEGRERTKTYSLNSRGYFRKERGARRSKILLVNTKGLDEPHIGHGDFGLVAELFDSTRTHTNRKEPDMNKVKLFSTVAHGNKSARRKAYNGSRRNIFSRRSFDKRNTEVTEKPGAKMFWNNFLVKMNGAPQNTSHGSKAQEIMKEACKTLPFTQNIVHENCDRMVIQNNLCFGKCISLHVPNQQDRRNTCSHCLPSKFTLNHLTLNCTGSKNVVKVVMMVEECTCEAHKSNFHQTAQFNMDTSTTLHH

Target ORF information:

RefSeq Version	NM_001088331.2
Organism	Xenopus laevis(African clawed frog)
Definition	Xenopus laevis cerberus 1, DAN family BMP antagonist S homeolog (cer1.S), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001088331.2

ORF Insert Sequence:

ATGTTACTAA ATGTACTCAG GATCTGTATT ATCGTCTGCC TTGTGAATGA TGGAGCAGGA 
AAACACTCAG AAGGACGAGA AAGGACAAAA ACATATTCAC TTAACAGCAG AGGTTACTTC 
AGAAAAGAAA GAGGAGCACG TAGGAGCAAG ATTCTGCTGG TGAATACTAA AGGTCTTGAT 
GAACCCCACA TTGGGCATGG TGATTTTGGC TTAGTAGCTG AACTATTTGA TTCCACCAGA 
ACACATACAA ACAGAAAAGA GCCAGACATG AACAAAGTCA AGCTTTTCTC AACAGTTGCC 
CATGGAAACA AAAGTGCAAG AAGAAAAGCT TACAATGGTT CTAGAAGGAA TATTTTTTCT 
CGCCGTTCTT TTGATAAAAG AAATACAGAG GTTACTGAAA AGCCTGGTGC CAAGATGTTC 
TGGAACAATT TTTTGGTTAA AATGAATGGA GCCCCACAGA ATACAAGCCA TGGCAGTAAA 
GCACAGGAAA TAATGAAAGA AGCTTGCAAA ACCTTGCCCT TCACTCAGAA TATTGTACAT 
GAAAACTGTG ACAGGATGGT GATACAGAAC AATCTGTGCT TTGGTAAATG CATCTCTCTC 
CATGTTCCAA ATCAGCAAGA TCGACGAAAT ACTTGTTCCC ATTGCTTGCC GTCCAAATTT 
ACCCTGAACC ACCTGACGCT GAATTGTACT GGATCTAAGA ATGTAGTAAA GGTTGTCATG 
ATGGTAGAGG AATGCACGTG TGAAGCTCAT AAGAGCAACT TCCACCAAAC TGCACAGTTT 
AACATGGATA CATCTACTAC CCTGCACCAT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Generating asymmetries in the early vertebrate embryo: the role of the Cerberus-like family.
The International journal of developmental biology53(8-10)1399-407(2009)
Belo JA,Silva AC,Borges AC,Filipe M,Bento M,Gon?alves L,Vitorino M,Salgueiro AM,Texeira V,Tavares AT,Marques S

Multiple functions of Cerberus cooperate to induce heart downstream of Nodal.
Developmental biology303(1)57-65(2007 Mar)
Foley AC,Korol O,Timmer AM,Mercola M

An atlas of differential gene expression during early Xenopus embryogenesis.
Mechanisms of development122(3)365-439(2005 Mar)
Pollet N,Muncke N,Verbeek B,Li Y,Fenger U,Delius H,Niehrs C

Neural induction in Xenopus: requirement for ectodermal and endomesodermal signals via Chordin, Noggin, beta-Catenin, and Cerberus.
PLoS biology2(5)E92(2004 May)
Kuroda H,Wessely O,De Robertis EM

Endogenous Cerberus activity is required for anterior head specification in Xenopus.
Development (Cambridge, England)130(20)4943-53(2003 Oct)
Silva AC,Filipe M,Kuerner KM,Steinbeisser H,Belo JA