NPY cDNA ORF clone, Sus scrofa(pig)

Gene
Clones
gRNAs

Summary

Gene Symbol	NPY
Entrez Gene ID	397304
Full Name	neuropeptide Y
Gene Type	protein-coding
Organism	Sus scrofa(pig)
Genome	Chromosome: 18 Map Location: 18\|18

mRNA and Protein(s)

mRNA	Protein	Name
NM_001256367.1	NP_001243296.1	pro-neuropeptide Y precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Alteration of neuropeptides in the lung tissue correlates brain death-induced neurogenic edema.
Barklin A, Theodorsson E, Tyvold SS, Larsson A, Granfeldt A, Sloth E, Tonnesen E
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation28(7)725-32(2009 Jul)

Effect of high dietary copper on weight gain and neuropeptide Y level in the hypothalamus of pigs.
Li J, Yan L, Zheng X, Liu G, Zhang N, Wang Z
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)22(1)33-8(2008)

Neuropeptide Y rapidly enhances [Ca2+]i transients and Ca2+ sparks in adult rat ventricular myocytes through Y1 receptor and PLC activation.
Heredia Mdel P, Delgado C, Pereira L, Perrier R, Richard S, Vassort G, B?nitah JP, G?mez AM
Journal of molecular and cellular cardiology38(1)205-12(2005 Jan)

Structural similarities of micelle-bound peptide YY (PYY) and neuropeptide Y (NPY) are related to their affinity profiles at the Y receptors.
Lerch M, Mayrhofer M, Zerbe O
Journal of molecular biology339(5)1153-68(2004 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Neuropeptide Y was released from the lung tissue of brain-dead pigs, and its concentration was related to the extent of neurogenic pulmonary edema
Title: Alteration of neuropeptides in the lung tissue correlates brain death-induced neurogenic edema.

High dietary copper appears to increase feed intake and promote weight gain by enhancing NPY concentration and NPY mRNA expression level in the hypothalamus of pigs.
Title: Effect of high dietary copper on weight gain and neuropeptide Y level in the hypothalamus of pigs.

NPY has a positive inotropic effect in isolated rat cardiac myocytes, which involves increase in Ca2+ release after activation of Y1 NPY receptor
Title: Neuropeptide Y rapidly enhances [Ca2+]i transients and Ca2+ sparks in adult rat ventricular myocytes through Y1 receptor and PLC activation.

Results show that the PP-fold is not important for recognition of peptide YY or neuropeptide Y at Y receptors.
Title: Structural similarities of micelle-bound peptide YY (PYY) and neuropeptide Y (NPY) are related to their affinity profiles at the Y receptors.

The following NPY gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NPY cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OSe28369	NM_001256367.1 Latest version!	Sus scrofa neuropeptide Y (NPY), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NPY ( NM_001256367.1 ) cDNA ORF clone, Sus scrofa(pig) -> NP_001243296.1 Sus scrofa neuropeptide Y (NPY), mRNA.

Price & Availability↑

CloneID	OSe28369
Clone ID Related Accession (Same CDS sequence)	NM_001256367.1
Accession Version	NM_001256367.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 294bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Sus scrofa(pig)
Product	pro-neuropeptide Y precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JQ026234.1. On Jan 23, 2012 this sequence version replaced XM_003484064.1. ##Evidence-Data-START## Transcript exon combination :: EW080005.2, EW082030.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01893941, SAMN02584789 [ECO:0000348] ##Evidence-Data-END##

ATGCTGGGTA GCAAGCGACT GGGGCTGTCC AGACTGACCC TCGCCCTGTC CCTGCTGGTG 
TGCCTGTGTG CGCTGGCCGA GGCGTACCCC TCCAAGCCCG ACAACCCCGG AGAGGACGCG 
CCGGCGGAGG ACTTGGCCAG ATACTACTCG GCGTTGAGAC ATTACATCAA CCTCATCACC 
AGGCAGAGAT ACGGAAAACG ATCTAGCCCC GAGACACTGA TTTCAGACCT CTTGATGAGA 
GAAGGCACGG AAAATGTTCC CAGAACTAGG CTCGAAGACC CTTCTGTGTG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001243296.1
CDS	183..476
Translation	MLGSKRLGLSRLTLALSLLVCLCALAEAYPSKPDNPGEDAPAEDLARYYSALRHYINLITRQRYGKRSSPETLISDLLMREGTENVPRTRLEDPSVW

Target ORF information:

RefSeq Version	NM_001256367.1
Organism	Sus scrofa(pig)
Definition	Sus scrofa neuropeptide Y (NPY), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256367.1

ORF Insert Sequence:

ATGCTGGGTA GCAAGCGACT GGGGCTGTCC AGACTGACCC TCGCCCTGTC CCTGCTGGTG 
TGCCTGTGTG CGCTGGCCGA GGCGTACCCC TCCAAGCCCG ACAACCCCGG AGAGGACGCG 
CCGGCGGAGG ACTTGGCCAG ATACTACTCG GCGTTGAGAC ATTACATCAA CCTCATCACC 
AGGCAGAGAT ACGGAAAACG ATCTAGCCCC GAGACACTGA TTTCAGACCT CTTGATGAGA 
GAAGGCACGG AAAATGTTCC CAGAACTAGG CTCGAAGACC CTTCTGTGTG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Alteration of neuropeptides in the lung tissue correlates brain death-induced neurogenic edema.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation28(7)725-32(2009 Jul)
Barklin A,Theodorsson E,Tyvold SS,Larsson A,Granfeldt A,Sloth E,Tonnesen E

Effect of high dietary copper on weight gain and neuropeptide Y level in the hypothalamus of pigs.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)22(1)33-8(2008)
Li J,Yan L,Zheng X,Liu G,Zhang N,Wang Z

Neuropeptide Y rapidly enhances [Ca2+]i transients and Ca2+ sparks in adult rat ventricular myocytes through Y1 receptor and PLC activation.
Journal of molecular and cellular cardiology38(1)205-12(2005 Jan)
Heredia Mdel P,Delgado C,Pereira L,Perrier R,Richard S,Vassort G,B?nitah JP,G?mez AM

Structural similarities of micelle-bound peptide YY (PYY) and neuropeptide Y (NPY) are related to their affinity profiles at the Y receptors.
Journal of molecular biology339(5)1153-68(2004 Jun)
Lerch M,Mayrhofer M,Zerbe O