Hamp cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hamp
Entrez Gene ID	84604
Full Name	hepcidin antimicrobial peptide
Synonyms	Hepc
General protein information	Preferred Names hepcidin antimicrobial peptide Names hepcidin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q21
Summary	may play a role in the regulation of iron metabolism [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053469.1	NP_445921.1	hepcidin precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Hepcidin and DNA promoter methylation in hepatocellular carcinoma.
Udali S, Castagna A, Corbella M, Ruzzenente A, Moruzzi S, Mazzi F, Campagnaro T, Santis D, Franceschi A, Pattini P, Gottardo R, Olivieri O, Perbellini L, Guglielmi A, Choi SW, Girelli D, Friso S
European journal of clinical investigation(2017 Dec)

Interleukin-6 and hepcidin expression changes in cardiac tissue of long-term trained and untrained rats after exhaustive exercise
Sar?kaya B, Dursun AD, Taylan Deveden EY, P?nar L
Turkish journal of medical sciences47(6)1940-1946(2017 Dec)

Alterations in transaminase activity and serum level of leptin and hepcidin induced by high fat diet in albino rats.
Khawar MB, Sheikh N
Journal of biological regulators and homeostatic agents31(4)951-956(2017 Oct-Dec)

Acidic Polysaccharide from
Wang K, Wu J, Cheng F, Huang X, Zeng F, Zhang Y
Oxidative medicine and cellular longevity20177601592(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

downregulation of ferroportin-1 and ceruloplasmin caused by hepcidin enhanced iron-dependent oxidative damage and may be the potential mechanism of subarachnoid hemorrhage .
Title: Role of hepcidin and its downstream proteins in early brain injury after experimental subarachnoid hemorrhage in rats.

when a high erythropoietic stimulus occurs, hepcidin synthesis is mainly regulated by transferrin saturation; however, when the erythropoiesis rate reaches a specific threshold, extramedullary hematopoiesis is triggered, and the control of hepcidin synthesis is switched to matriptase-2, thus inhibiting hepcidin synthesis.
Title: Recombinant human erythropoietin-induced erythropoiesis regulates hepcidin expression over iron status in the rat.

The data of in vitro and in vivo research evidenced on involvement of Hepc in formation of breast cancer cells malignant phenotype and their resistance to doxorubicin.
Title: Hepcidin as a possible marker in determination of malignancy degree and sensitivity of breast cancer cells to cytostatic drugs.

liver iron overload was an important stimuli for hepcidin synthesis, stronger than the inhibitory effect of high rHuEPO doses; moreover, the findings raised the hypothesis that when high inflammation (triggering hepcidin expression) was associated with increased iron stores in hemodialysis patients, hepcidin expression was also upregulated via BMP6, enhancing hepcidin synthesis, leading, therefore, to worsening of anemia
Title: Liver iron is a major regulator of hepcidin gene expression via BMP/SMAD pathway in a rat model of chronic renal failure under treatment with high rHuEPO doses.

Hepcidin may be considered as a potential marker of impaired renal function.
Title: Hepcidin as a Biomarker of Impaired Renal Function in Rat Models for Chronic Allograft Nephropathy.

The following Hamp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hamp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09638	NM_053469.1 Latest version!	Rattus norvegicus hepcidin antimicrobial peptide (Hamp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hamp ( NM_053469.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_445921.1 Rattus norvegicus hepcidin antimicrobial peptide (Hamp), mRNA.

Price & Availability↑

CloneID	ORa09638
Clone ID Related Accession (Same CDS sequence)	NM_053469.1
Accession Version	NM_053469.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 255bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	hepcidin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF344185.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF344185.1, FQ222617.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906353, SAMN01906354 [ECO:0000348] ##Evidence-Data-END##

ATGGCACTAA GCACTCGGAT CCAGGCTGCC TGTCTCCTGC TTCTCCTCCT GGCCAGCCTG 
AGCAGCGGTG CCTATCTCCG GCAACAGACG AGACAGACTA CGGCTCTGCA GCCTTGGCAT 
GGGGCAGAAA GCAAGACTGA TGACAGTGCG CTGCTGATGC TGAAGCGAAG GAAGCGAGAC 
ACCAACTTCC CCATATGCCT CTTCTGCTGT AAATGCTGTA AGAATTCCTC CTGTGGTCTC 
TGTTGCATAA CATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_445921.1
CDS	25..279
Translation	MALSTRIQAACLLLLLLASLSSGAYLRQQTRQTTALQPWHGAESKTDDSALLMLKRRKRDTNFPICLFCCKCCKNSSCGLCCIT

Target ORF information:

RefSeq Version	NM_053469.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus hepcidin antimicrobial peptide (Hamp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053469.1

ORF Insert Sequence:

ATGGCACTAA GCACTCGGAT CCAGGCTGCC TGTCTCCTGC TTCTCCTCCT GGCCAGCCTG 
AGCAGCGGTG CCTATCTCCG GCAACAGACG AGACAGACTA CGGCTCTGCA GCCTTGGCAT 
GGGGCAGAAA GCAAGACTGA TGACAGTGCG CTGCTGATGC TGAAGCGAAG GAAGCGAGAC 
ACCAACTTCC CCATATGCCT CTTCTGCTGT AAATGCTGTA AGAATTCCTC CTGTGGTCTC 
TGTTGCATAA CATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hepcidin and DNA promoter methylation in hepatocellular carcinoma.
European journal of clinical investigation(2017 Dec)
Udali S,Castagna A,Corbella M,Ruzzenente A,Moruzzi S,Mazzi F,Campagnaro T,Santis D,Franceschi A,Pattini P,Gottardo R,Olivieri O,Perbellini L,Guglielmi A,Choi SW,Girelli D,Friso S

Interleukin-6 and hepcidin expression changes in cardiac tissue of long-term trained and untrained rats after exhaustive exercise
Turkish journal of medical sciences47(6)1940-1946(2017 Dec)
Sar?kaya B,Dursun AD,Taylan Deveden EY,P?nar L

Alterations in transaminase activity and serum level of leptin and hepcidin induced by high fat diet in albino rats.
Journal of biological regulators and homeostatic agents31(4)951-956(2017 Oct-Dec)
Khawar MB,Sheikh N

Acidic Polysaccharide from
Oxidative medicine and cellular longevity20177601592(2017)
Wang K,Wu J,Cheng F,Huang X,Zeng F,Zhang Y