Sfrp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sfrp1
Entrez Gene ID	84402
Full Name	secreted frizzled-related protein 1
Synonyms	sFRP-1
General protein information	Preferred Names secreted frizzled-related protein 1 Names secreted frizzled-related protein 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16q12.5
Summary	a secreted protein involved in binding Wnt and antagonizing Wnt signaling [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001276712.1	NP_001263641.1	secreted frizzled-related protein 1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	SFRP1	NP_003003.3
Pan troglodytes (chimpanzee)	SFRP1	XP_001138037.1
Canis lupus familiaris (dog)	SFRP1	XP_003639612.1
Mus musculus (house mouse)	Sfrp1	NP_038862.2
Xenopus tropicalis (tropical clawed frog)	sfrp1	NP_001116878.1
Rattus norvegicus (Norway rat)	Sfrp1	NP_001263641.1
	SFRP1	XP_001094070.1
Gallus gallus (chicken)	SFRP1	NP_989884.1
Danio rerio (zebrafish)	sfrp1b	NP_001077040.1
Danio rerio (zebrafish)	sfrp1a	NP_991148.1
Bos taurus (cattle)	SFRP1	NP_776885.1

Gene Ontology
Bibliography

Related articles in PubMed

miR-542-3p prevents ovariectomy-induced osteoporosis in rats via targeting SFRP1.
Zhang X, Zhu Y, Zhang C, Liu J, Sun T, Li D, Na Q, Teng Z
Journal of cellular physiology(2018 Jan)

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.
Barallobre-Barreiro J, Gupta SK, Zoccarato A, Kitazume-Taneike R, Fava M, Yin X, Werner T, Hirt MN, Zampetaki A, Viviano A, Chong M, Bern M, Kourliouros A, Domenech N, Willeit P, Shah AM, Jahangiri M, Schaefer L, Fischer JW, Iozzo RV, Viner R, Thum T, Heineke J, Kichler A, Otsu K, Mayr M
Circulation134(11)817-32(2016 Sep)

Secreted frizzled related protein 1 protects H9C2 cells from hypoxia/re-oxygenation injury by blocking the Wnt signaling pathway.
Tao J, Abudoukelimu M, Ma YT, Yang YN, Li XM, Chen BD, Liu F, He CH, Li HY
Lipids in health and disease1572(2016 Apr)

FrzA gene protects cardiomyocytes from H2O2-induced oxidative stress through restraining the Wnt/Frizzled pathway.
Tao J, Chen BD, Ma YT, Yang YN, Li XM, Ma X, Yu ZX, Liu F, Xiang Y, Chen Y
Lipids in health and disease1490(2015 Aug)

Immunohistochemical expression of SFRP1 and SFRP3 proteins in normal and malignant reproductive tissues of rats and humans.
Partl JZ, Fabijanovic D, Skrtic A, Vranic S, Martic TN, Serman L
Applied immunohistochemistry & molecular morphology : AIMM22(9)681-7(2014 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Sfrp1 directly protected cardiomyoblasts from hypoxia and reoxygenation-induced reperfusion injury and apoptosis through inhibition of the Wnt signaling pathway and plays cardioprotective role on ischemic damage.
Title: Secreted frizzled related protein 1 protects H9C2 cells from hypoxia/re-oxygenation injury by blocking the Wnt signaling pathway.

Sfrp1 gene protects cardiomyocytes from H2O2-induced oxidative stress through restraining the Wnt/Frizzled pathway.
Title: FrzA gene protects cardiomyocytes from H2O2-induced oxidative stress through restraining the Wnt/Frizzled pathway.

study indicates that increased expression of both SFRP1 and SFRP3 may contribute to the pathogenesis of IUGR placental dysfunction, whereas the loss of these proteins may be involved in the development of human trophoblastic tumors.
Title: Immunohistochemical expression of SFRP1 and SFRP3 proteins in normal and malignant reproductive tissues of rats and humans.

critical role of sFRP1 in regulating spermiation via its effects on the FAK signaling and retention of nectin-3 adhesion complex at the apical ectoplasmic specialization
Title: Secreted Frizzled-related protein 1 (sFRP1) regulates spermatid adhesion in the testis via dephosphorylation of focal adhesion kinase and the nectin-3 adhesion protein complex.

CSF-1 and EMAP-II may contribute to the reduced SFRP-1 expression seen on day 3, while TNF-alpha may contribute to the reduced SFRP-1 expression at day 9 in dental follicle.
Title: Regulation of SFRP-1 expression in the rat dental follicle.

The following Sfrp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sfrp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11511	NM_001276712.1 Latest version!	Rattus norvegicus secreted frizzled-related protein 1 (Sfrp1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sfrp1 ( NM_001276712.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001263641.1 Rattus norvegicus secreted frizzled-related protein 1 (Sfrp1), mRNA.

Price & Availability↑

CloneID	ORa11511
Clone ID Related Accession (Same CDS sequence)	NM_001276712.1
Accession Version	NM_001276712.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 942bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Rattus norvegicus(Norway rat)
Product	secreted frizzled-related protein 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07072522.1. On or before Feb 28, 2013 this sequence version replaced XM_224987.6, XM_001072532.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF167308.1, CB736173.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMN01906347 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCGTCG GGCGCAACGC GCGGGGTCGC GGCGGGGCCG CCTCCGGCGT GCTGCTGGCG 
TTGGCCGCCG CGCTGCTGGC CGCGGGTTCG GCCAGCGAGT ACGACTACGT GAGCTTCCAG 
TCGGATATCG GCTCCTATCA GAGCGGGCGC TTCTACACCA AGCCCCCGCA GTGCGTGGAC 
ATCCCGGTGG ACCTGCGGCT GTGCCACAAC GTGGGCTACA AGAAGATGGT GCTGCCCAAC 
CTGCTGGAGC ACGAGACCAT GGCAGAGGTG AAGCAGCAGG CCAGCAGCTG GGTGCCGCTG 
CTCAACAAGA ACTGCCACAT GGGCACCCAG GTCTTCCTCT GCTCGCTCTT CGCGCCCGTC 
TGTCTGGACC GGCCTATCTA CCCGTGTCGC TGGCTCTGCG AGGCTGTTCG CGACTCGTGC 
GAGCCGGTCA TGCAGTTCTT CGGCTTCTAC TGGCCCGAGA TGCTCAAATG TGACAAGTTC 
CCCGAGGGCG ACGTCTGCAT CGCCATGACC CCGCCCAATG CCACCGAAGC CTCGAAGCCC 
CAAGGTACAA CAGTGTGTCC TCCGTGTGAC AACGAGTTGA AATCGGAGGC CATCATCGAA 
CATCTCTGTG CAAGCGAGTT TGCGCTGAGA ATGAAAATCA AAGAAGTAAA AAAGGAACGG 
GTGCAAGAGA TTGTCCCCAA GAAGAAGAAA CCCTTGAAGC TGGGGCCCAT CAAGAAGAAG 
GAGCTGAAGC GGCTCGTGCT TTTCCTAAAG AATGGCGCCG ACTGTCCCTG CCACCAGCTG 
GACAACCTCA GCCACAACTT CCTCATCATG GGGCGCAAGG TGAAGAGCCA GTACTTGCTC 
ACAGCCATTC ACAAGTGGGA CAAGAAAAAC AAGGAGTTCA AAAACTTCAT GAAGAAAATG 
AAAAACCACG AGTGTCCCAC CTTCCAGTCT GTTTTTAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001263641.1
CDS	1..942
Translation	MGVGRNARGRGGAASGVLLALAAALLAAGSASEYDYVSFQSDIGSYQSGRFYTKPPQCVDIPVDLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHMGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALRMKIKEVKKERVQEIVPKKKKPLKLGPIKKKELKRLVLFLKNGADCPCHQLDNLSHNFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKKMKNHECPTFQSVFK

Target ORF information:

RefSeq Version	NM_001276712.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus secreted frizzled-related protein 1 (Sfrp1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001276712.1

ORF Insert Sequence:

ATGGGCGTCG GGCGCAACGC GCGGGGTCGC GGCGGGGCCG CCTCCGGCGT GCTGCTGGCG 
TTGGCCGCCG CGCTGCTGGC CGCGGGTTCG GCCAGCGAGT ACGACTACGT GAGCTTCCAG 
TCGGATATCG GCTCCTATCA GAGCGGGCGC TTCTACACCA AGCCCCCGCA GTGCGTGGAC 
ATCCCGGTGG ACCTGCGGCT GTGCCACAAC GTGGGCTACA AGAAGATGGT GCTGCCCAAC 
CTGCTGGAGC ACGAGACCAT GGCAGAGGTG AAGCAGCAGG CCAGCAGCTG GGTGCCGCTG 
CTCAACAAGA ACTGCCACAT GGGCACCCAG GTCTTCCTCT GCTCGCTCTT CGCGCCCGTC 
TGTCTGGACC GGCCTATCTA CCCGTGTCGC TGGCTCTGCG AGGCTGTTCG CGACTCGTGC 
GAGCCGGTCA TGCAGTTCTT CGGCTTCTAC TGGCCCGAGA TGCTCAAATG TGACAAGTTC 
CCCGAGGGCG ACGTCTGCAT CGCCATGACC CCGCCCAATG CCACCGAAGC CTCGAAGCCC 
CAAGGTACAA CAGTGTGTCC TCCGTGTGAC AACGAGTTGA AATCGGAGGC CATCATCGAA 
CATCTCTGTG CAAGCGAGTT TGCGCTGAGA ATGAAAATCA AAGAAGTAAA AAAGGAACGG 
GTGCAAGAGA TTGTCCCCAA GAAGAAGAAA CCCTTGAAGC TGGGGCCCAT CAAGAAGAAG 
GAGCTGAAGC GGCTCGTGCT TTTCCTAAAG AATGGCGCCG ACTGTCCCTG CCACCAGCTG 
GACAACCTCA GCCACAACTT CCTCATCATG GGGCGCAAGG TGAAGAGCCA GTACTTGCTC 
ACAGCCATTC ACAAGTGGGA CAAGAAAAAC AAGGAGTTCA AAAACTTCAT GAAGAAAATG 
AAAAACCACG AGTGTCCCAC CTTCCAGTCT GTTTTTAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

miR-542-3p prevents ovariectomy-induced osteoporosis in rats via targeting SFRP1.
Journal of cellular physiology(2018 Jan)
Zhang X,Zhu Y,Zhang C,Liu J,Sun T,Li D,Na Q,Teng Z

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.
Circulation134(11)817-32(2016 Sep)
Barallobre-Barreiro J,Gupta SK,Zoccarato A,Kitazume-Taneike R,Fava M,Yin X,Werner T,Hirt MN,Zampetaki A,Viviano A,Chong M,Bern M,Kourliouros A,Domenech N,Willeit P,Shah AM,Jahangiri M,Schaefer L,Fischer JW,Iozzo RV,Viner R,Thum T,Heineke J,Kichler A,Otsu K,Mayr M

Secreted frizzled related protein 1 protects H9C2 cells from hypoxia/re-oxygenation injury by blocking the Wnt signaling pathway.
Lipids in health and disease1572(2016 Apr)
Tao J,Abudoukelimu M,Ma YT,Yang YN,Li XM,Chen BD,Liu F,He CH,Li HY

FrzA gene protects cardiomyocytes from H2O2-induced oxidative stress through restraining the Wnt/Frizzled pathway.
Lipids in health and disease1490(2015 Aug)
Tao J,Chen BD,Ma YT,Yang YN,Li XM,Ma X,Yu ZX,Liu F,Xiang Y,Chen Y

Immunohistochemical expression of SFRP1 and SFRP3 proteins in normal and malignant reproductive tissues of rats and humans.
Applied immunohistochemistry & molecular morphology : AIMM22(9)681-7(2014 Oct)
Partl JZ,Fabijanovic D,Skrtic A,Vranic S,Martic TN,Serman L

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Sfrp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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