Dnmt1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dnmt1
Entrez Gene ID	84350
Full Name	DNA methyltransferase 1
General protein information	Preferred Names DNA methyltransferase 1 Names DNA (cytosine-5)-methyltransferase 1 DNA (cytosine-5-)-methyltransferase 1 DNA MTase RnoIP DNA methyltransferase (cytosine-5) 1 DNA methyltransferase I MCMT m.RnoIP
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q13
Summary	methylates genomic DNA; involved in processes of gene inactivation, chromatin organization, X chromosome inactivation and genomic imprinting [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053354.3	NP_445806.3	DNA (cytosine-5)-methyltransferase 1

Pathways from BioSystems

Homologies

Arabidopsis thaliana (thale cress)	MEE57	NP_193097.1
Homo sapiens (human)	DNMT1	NP_001124295.1
Bos taurus (cattle)	DNMT1	NP_872592.2
Danio rerio (zebrafish)	dnmt1	NP_571264.1
Oryza sativa (rice)	Os03g0798300	NP_001051569.1
Oryza sativa (rice)	Os07g0182900	NP_001059052.1
Canis lupus familiaris (dog)	DNMT1	XP_533919.4
Arabidopsis thaliana (thale cress)	AT4G08990	NP_192638.1
Xenopus tropicalis (tropical clawed frog)	dnmt1	XP_002934384.1
Pan troglodytes (chimpanzee)	DNMT1	XP_512361.3
	DNMT1	XP_001104704.2
Mus musculus (house mouse)	Dnmt1	NP_001186360.2
Rattus norvegicus (Norway rat)	Dnmt1	NP_445806.3
Arabidopsis thaliana (thale cress)	DMT2	NP_193150.1
Arabidopsis thaliana (thale cress)	MET1	NP_199727.1
Gallus gallus (chicken)	DNMT1	NP_996835.1

Gene Ontology
Bibliography

Related articles in PubMed

Homocysteine inhibits endothelial progenitor cells proliferation via DNMT1-mediated hypomethylation of Cyclin A.
Zhang HP, Wang YH, Ma SC, Zhang H, Yang AN, Yang XL, Zhang MH, Sun JM, Hao YJ, Jiang YD
Experimental cell research362(1)217-226(2018 Jan)

MiR-140-5p regulates hypoxia-mediated human pulmonary artery smooth muscle cell proliferation, apoptosis and differentiation by targeting Dnmt1 and promoting SOD2 expression.
Zhang Y, Xu J
Biochemical and biophysical research communications473(1)342-348(2016 Apr)

Multiple isoforms of DNA methyltransferase are encoded by the vertebrate cytosine DNA methyltransferase gene.
Deng J, Szyf M
The Journal of biological chemistry273(36)22869-72(1998 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

hypomethylation of FABP4 was regulated by DNMT1, which was a direct target of miR-152/148a, in pre-eclampsia model
Title: Modulation of FABP4 hypomethylation by DNMT1 and its inverse interaction with miR-148a/152 in the placenta of preeclamptic rats and HTR-8 cells.

DNMT1 activates the canonical Wnt signaling in rheumatoid arthritis model rats via a crucial functional crosstalk between miR-152 and the DNMT1, MeCP2
Title: DNMT1 activates the canonical Wnt signaling in rheumatoid arthritis model rats via a crucial functional crosstalk between miR-152 and the DNMT1, MeCP2.

Results identify LRRFIP1, SMARCA4, and DNMT1 as novel regulators of macrophage multinucleation.
Title: Integrating phosphoproteome and transcriptome reveals new determinants of macrophage multinucleation.

Acute restraint stress evokes adaptive changes in global DNA methylation of rat brain that are independent of the expression of the Dnmt1 gene but might be linked to abnormal expression of the Bdnf gene in the PAG.
Title: Acute stress affects the global DNA methylation profile in rat brain: modulation by physical exercise.

Data indicate that increased microRNA miR-152 in fibroblast-like synoviocytes (FLS) results in a marked reduction of DNA methyltransferas 1 (DNMT1) expression.
Title: MicroRNA-152 modulates the canonical Wnt pathway activation by targeting DNA methyltransferase 1 in arthritic rat model.

The following Dnmt1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dnmt1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09340	NM_053354.3 Latest version!	Rattus norvegicus DNA methyltransferase 1 (Dnmt1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$1189.30 $1699.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dnmt1 ( NM_053354.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_445806.3 Rattus norvegicus DNA methyltransferase 1 (Dnmt1), mRNA.

Price & Availability↑

CloneID	ORa09340
Clone ID Related Accession (Same CDS sequence)	NM_053354.3
Accession Version	NM_053354.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4866bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	DNA (cytosine-5)-methyltransferase 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473993.2. On Nov 25, 2008 this sequence version replaced NM_053354.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGCCAGCAC GAACAGCTCC AGCCCGAGTG CCTGCACTTG CCTCCCCGGC AGGCTCGCTC 
CCCGACCATG TCCGCAGGCG GCTCAAAGAC TTGGAAAGAG ATGGCTTAAC AGAAAAGGAG 
TGTGTGAAAG AGAAATTGAA CTTACTGCAT GAATTCCTGC AAACAGAAAT AAAAAGCCAG 
CTATGCGACT TGGAAACCAA ACTACATAAA GAGGAATTGT CTGAGGAAGG CTACCTGGCT 
AAAGTCAAGA CCCTTCTAAA TAAGGATTTG TGCCTGGAGA ACGGAACACT CTCTCTCACT 
CAGAAAGCCA ACGGTTGTCC TGCCAACGGG AGTCGGCCAA CCTGGAAAGC AGAAATGGCA 
GACTCAAACC GATCCCCAAG ATCCAGGCCC AAGCCTCGGG GACCCAGGAG GAGCAAGTCG 
GACAGTGAGA CCATGATTGA AGCTTCATCT AGTTCGGTGG CTACGAGGAG AACCACCAGG 
CAGACCACCA TCACGTCTCA CTTCAAGGGT CCCGCTAAAC GGAAACCCAA GGAAGACTCT 
GAAAAGGGAA ACGCAAATGA ATCTGCTGCA GAGGAGAGAG ACCAGGATAA GAAACGCAGA 
GTCGCAGGCA CAGAGAGTCG TGCCAGTCGT GCCGGAGAGT CTGTGGAGAA ACCTGAACGA 
GTAAGGCCAG GAACCCAGCT GTGTCAGGAA GAGCAAGGTG AACAGGAAGA TGACAGGAGA 
CCTCGACGTC AAACCAGAGA GCTAGCATCA AGGCGGAAAT CAAGGGAGGA CCCAGACAGA 
GAAGCAAGGC CAGGAACTCA CTTGGATGTG GACGATGACG ATGAAAAGGA CAAAAGAAGT 
TCCAGGCCCA GAAGCCAGCC CAGAGATCTA GCCACCAAAC GGAGACCCAA GGAAGAAGTA 
GAGCAGATCA CTCCAGAGCC TCCCGAGGGC AAAGATGAGG ACGAAAGGGA GGAGAAGAGA 
CGAAAAACGA CACGTAAAAA GCCGGAACCA CTCAGCATTC CCGTACAGAG CAGAGTGGAG 
AGAAAAGCCT CTCAGGGCAA AGCAAGTGCA ATCCCAAAGC TCAACCCGCC ACAGTGCCCT 
GAGTGTGGCC AGTACCTAGA TGACCCTGAC CTGAAGTACC AGCAGCACCC TGTGGATGCT 
GTGGATGAAC CCCAGATGCT GACCAATGAG GCACTGTCCG TCTTTGACTC CAACTCGTCT 
TGGTTTGAGA CCTATGATTC CTCTCCCATG CATAAGTTCA CTTTCTTCAG TGTGTATTGC 
AGTCGCGGTC ACTTGTGTCC TGTCGACACT GGTCTCATTG AGAAGAACGT TGAACTCTAC 
TTTTCTGGTG TTGCCAAAGC AATTCATGAA GAAAATCCGT CTGTGGAAGG TGGTGTTAAT 
GGCAAGAACC TGGGGCCAAT CAATCAGTGG TGGATCAGTG GCTTTGACGG TGGCGAGAAG 
GCGCTCATTG GCTTTTCTAC CGCATTTGCT GAATACTTTC TGATGGAGCC CAGCCCAGAG 
TATGCACCAA TATTTGGGCT GATGCAGGAG AAAATTTACA TCAGCAAGAT TGTGGTCGAG 
TTCTTGCAGA GCAATCCTGA CGCTGTCTAT GAAGACTTGA TCAATAAGAT CGAGACCACT 
GTTCCTCCTT CTGCCATCAA TGTGAACCGG TTCACCGAGG ACTCCCTCCT ACGCCATGCC 
CAGTTTGTGG TGAGCCAGGT AGAAAGTTAC GACGACGCTA AGGACGATGA TGAGACGCCC 
ATCTTCTTGT CTCCCTGTAT GAGGTCCCTG ATCCATTTGG CTGGTGTCTC GCTGGGACAG 
AGGCGAGCAA CAAGGCGCAC GGTCATCAAT TCTGCCAAAG TGAAGCGCAA GGGGCCCACA 
AAAGCCACCA CCACCAAGCT GGTCTATCAG ATCTTCGACA CTTTCTTCTC GGAGCAGATC 
GAGAAGGATG ACAAGGAGGA CAAAGAGAAC ACCATGAAGC GCCGCCGGTG TGGTGTCTGT 
GAGGTCTGTC AACAGCCTGA GTGTGGGAAG TGCAAGGCGT GCAAAGACAT GGTTAAGTTT 
GGTGGCACCG GACGGAGTAA ACAGGCTTGC CTCAAGAGGA GGTGTCCTAA CTTGGCCGTA 
AAGGAGGCAG ATGAAGACGA AGAAGCTGAT GATGATATAC CAGAGTTGCC GTCACCCAAA 
AAGTTGCACC AAGGGAAGAA GAAGAAACAG AATAAGGATC GCATCTCCTG GCTCGGGGAG 
CCTGTGAAGA TCGAAGAGAA CAGAACTTAC TATTGGAAGG TGAGCATCGA CGAAGAGACT 
CTGGAGGTGG GCGACTGCGT CTCGGTCATT CCGGATGATC CCTCCAAACC ACTGTATCTA 
GCCAGGGTCA CAGCACTGTG GGAAGACAAG AACGGGCAGA TGTTCCATGC ACACTGGTTC 
TGCGCGGGGA CAGACACGGT CCTCGGAGCC ACCTCTGACC CTCTGGAGCT GTTCCTTGTA 
GGCGAGTGTG AAAACATGCA ACTTTCCTAC ATCCACAGCA AGGTCAAGGT CATCTACAGA 
GGGCCTTCCC CAAACTGGGC CATGGAGGGA GGCATGGACC CTGAGGCCAT GTTGCCGGGG 
GCTGAGGATG GGAAGACCTA CTTCTACCAG TTCTGGTACA GCCAGGACTA CGCAAGGTTT 
GAGTCCCCAC CCAAGACCCA GCCGACGGAG GACAATAAGC ACAAGTTCTG CCTATCTTGT 
ATCCGGCTGG CTGAGCTGAG ACAAAAAGAA ATGCCCAAAG TCCTGGAACA ACTTGAGGAG 
GTGGACGGCC GGGTCTACTG CAGTTCTATC ACCAAGAACG GTGTTGTCTA CCGACTGGGT 
GACAGTGTGT ACCTGCCTCC TGAGGCCTTT ACTTTCAACA TCAAAATGGC CAGCCCCATG 
AAACGCTCTA AGAGGGACCC TGTGAATGAG AACCTGTACC CCGAGCATTA CCGCAAGTAT 
TCCGACTACA TCAAAGGAAG CAACCTGGAC GCCCCTGAAC CCTATCGGAT TGGTCGGATA 
AAAGAGATCC ACTGTGGCAA GAAGAAAGGT GGCAAGGTCA ATGAGGCAGA CATCAAGATC 
AGGCTCTACA AGTTCTATAG GCCTGAGAAC ACCCACAAGT CCATCCAGGC AACCTACCAC 
GCCGACATCA ACCTGCTCTA CTGGAGCGAT GAGGAAGCCG TGGTGGACTT CAGCGACGTG 
CAAGGCCGCT GCACCGTGGA GTACGGAGAG GACCTGCTTG AGAGCATCCA GGATTACTCA 
CAGGGCGGCC CCGACCGCTT CTACTTTCTC GAGGCCTACA ATTCAAAGAC TAAAAGCTTT 
GAAGACCCTC CGAACCATGC CCGCAGCCCT GGGAACAAAG GCAAAGGAAA GGGGAAAGGG 
AAAGGGAAGG GAAAACCTCA GGTATCAGAG CCCAAAGAGC CCGAGGCAGC CATCAAACTG 
CCTAAGCTGC GGACCCTGGA TGTGTTTTCT GGCTGTGGAG GATTAACAGA AGGATTCCAC 
CAAGCAGGCA TCTCGGAGAC GCTGTGGGCC ATCGAGATGT GGGAACCAGC AGCCCAGGCA 
TTTCGGCTGA ACAACCCTGG CACCACGGTG TTCACAGAGG ACTGCAACGT GCTTCTCAAG 
CTGGTCATGG CTGGTGAGGT GACCAACTCT CTGGGCCAGA GGCTGCCACA GAAGGGCGAT 
GTGGAGATGC TGTGTGGTGG GCCGCCCTGC CAGGGCTTCA GTGGCATGAA CCGTTTCAAC 
TCTCGTACTT ACTCCAAGTT CAAAAACTCC CTCGTGGTCT CCTTCCTCAG CTACTGTGAC 
TACTACCGGC CTCGGTTCTT CCTCTTGGAG AATGTCAGGA ACTTCGTGTC CTTCAGGCGC 
TCCATGGTGC TGAAGCTCAC ACTGCGCTGC CTGGTCCGCA TGGGCTACCA GTGCACCTTC 
GGTGTGCTCC AGGCTGGACA GTATGGTGTG GCCCAGACAC GAAGGAGGGC CATCATCTTG 
GCTGCAGCCC CTGGAGAGAA GCTGCCTCTG TTCCCAGAAC CTCTACACGT GTTTGCCCCC 
CGTGCCTGCC AGCTGAGTGT TGTGGTGGAC GACAAGAAGT TCGTTAGCAA CATTACAAGG 
CTAAGCTCGG GTCCCTTCCG AACCATCACG GTGCGAGATA CCATGTCTGA CCTCCCTGAG 
ATCCAGAATG GAGCCTCAGC CCCCGAGATC TCCTACAATG GAGAGCCACA GTCCTGGTTC 
CAGAGGCAGC TGCGAGGGTC GCACTACCAG CCCATCCTCA GGGACCATAT CTGCAAGGAC 
ATGAGCGCGC TGGTGGCTGC CCGTATGCGG CACATCCCGC TGTCCCCAGG ATCGGATTGG 
CGTGACCTGC CCAACATACA AGTGCGGCTG AGAGATGGCG TCATAACCAA TAAACTTCGC 
TACACTTTCC ACGACACGAA GAACGGCTGC AGCAGCACCG GGGCCCTGCG TGGGGTCTGC 
TCCTGTGCGG AAGGCAAGAC CTGCGACCCT GCTTCCAGAC AATTCAACAC GCTCATCCCC 
TGGTGCCTGC CGCACACTGG GAACCGGCAC AACCACTGGG CTGGCCTCTA CGGGCGTCTG 
GAGTGGGATG GCTTCTTCAG TACCACCGTC ACCAACCCTG AGCCCATGGG CAAGCAAGGC 
CGGGTGCTCC ATCCCGAGCA GCACCGGGTC GTGAGTGTGC GGGAATGTGC TCGCTCCCAA 
GGCTTTCCAG ATACCTACCG GTTATTCGGC AACATCCTGG ACAGACACCG GCAGGTGGGG 
AACGCTGTGC CACCACCACT GGCCAAAGCC ATCGGCCTGG AGATTAAGCT CTGTCTGCTG 
GCCAGCGCTC AGGAGAGTGC CTCAGCTGCA GTTAAAGGAA AGGAGGAGAC TACTACCGAG 
GACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_445806.3
CDS	81..4946
Translation	MPARTAPARVPALASPAGSLPDHVRRRLKDLERDGLTEKECVKEKLNLLHEFLQTEIKSQLCDLETKLHKEELSEEGYLAKVKTLLNKDLCLENGTLSLTQKANGCPANGSRPTWKAEMADSNRSPRSRPKPRGPRRSKSDSETMIEASSSSVATRRTTRQTTITSHFKGPAKRKPKEDSEKGNANESAAEERDQDKKRRVAGTESRASRAGESVEKPERVRPGTQLCQEEQGEQEDDRRPRRQTRELASRRKSREDPDREARPGTHLDVDDDDEKDKRSSRPRSQPRDLATKRRPKEEVEQITPEPPEGKDEDEREEKRRKTTRKKPEPLSIPVQSRVERKASQGKASAIPKLNPPQCPECGQYLDDPDLKYQQHPVDAVDEPQMLTNEALSVFDSNSSWFETYDSSPMHKFTFFSVYCSRGHLCPVDTGLIEKNVELYFSGVAKAIHEENPSVEGGVNGKNLGPINQWWISGFDGGEKALIGFSTAFAEYFLMEPSPEYAPIFGLMQEKIYISKIVVEFLQSNPDAVYEDLINKIETTVPPSAINVNRFTEDSLLRHAQFVVSQVESYDDAKDDDETPIFLSPCMRSLIHLAGVSLGQRRATRRTVINSAKVKRKGPTKATTTKLVYQIFDTFFSEQIEKDDKEDKENTMKRRRCGVCEVCQQPECGKCKACKDMVKFGGTGRSKQACLKRRCPNLAVKEADEDEEADDDIPELPSPKKLHQGKKKKQNKDRISWLGEPVKIEENRTYYWKVSIDEETLEVGDCVSVIPDDPSKPLYLARVTALWEDKNGQMFHAHWFCAGTDTVLGATSDPLELFLVGECENMQLSYIHSKVKVIYRGPSPNWAMEGGMDPEAMLPGAEDGKTYFYQFWYSQDYARFESPPKTQPTEDNKHKFCLSCIRLAELRQKEMPKVLEQLEEVDGRVYCSSITKNGVVYRLGDSVYLPPEAFTFNIKMASPMKRSKRDPVNENLYPEHYRKYSDYIKGSNLDAPEPYRIGRIKEIHCGKKKGGKVNEADIKIRLYKFYRPENTHKSIQATYHADINLLYWSDEEAVVDFSDVQGRCTVEYGEDLLESIQDYSQGGPDRFYFLEAYNSKTKSFEDPPNHARSPGNKGKGKGKGKGKGKPQVSEPKEPEAAIKLPKLRTLDVFSGCGGLTEGFHQAGISETLWAIEMWEPAAQAFRLNNPGTTVFTEDCNVLLKLVMAGEVTNSLGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDYYRPRFFLLENVRNFVSFRRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILAAAPGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMSDLPEIQNGASAPEISYNGEPQSWFQRQLRGSHYQPILRDHICKDMSALVAARMRHIPLSPGSDWRDLPNIQVRLRDGVITNKLRYTFHDTKNGCSSTGALRGVCSCAEGKTCDPASRQFNTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFPDTYRLFGNILDRHRQVGNAVPPPLAKAIGLEIKLCLLASAQESASAAVKGKEETTTED

Target ORF information:

RefSeq Version	NM_053354.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus DNA methyltransferase 1 (Dnmt1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053354.3

ORF Insert Sequence:

ATGCCAGCAC GAACAGCTCC AGCCCGAGTG CCTGCACTTG CCTCCCCGGC AGGCTCGCTC 
CCCGACCATG TCCGCAGGCG GCTCAAAGAC TTGGAAAGAG ATGGCTTAAC AGAAAAGGAG 
TGTGTGAAAG AGAAATTGAA CTTACTGCAT GAATTCCTGC AAACAGAAAT AAAAAGCCAG 
CTATGCGACT TGGAAACCAA ACTACATAAA GAGGAATTGT CTGAGGAAGG CTACCTGGCT 
AAAGTCAAGA CCCTTCTAAA TAAGGATTTG TGCCTGGAGA ACGGAACACT CTCTCTCACT 
CAGAAAGCCA ACGGTTGTCC TGCCAACGGG AGTCGGCCAA CCTGGAAAGC AGAAATGGCA 
GACTCAAACC GATCCCCAAG ATCCAGGCCC AAGCCTCGGG GACCCAGGAG GAGCAAGTCG 
GACAGTGAGA CCATGATTGA AGCTTCATCT AGTTCGGTGG CTACGAGGAG AACCACCAGG 
CAGACCACCA TCACGTCTCA CTTCAAGGGT CCCGCTAAAC GGAAACCCAA GGAAGACTCT 
GAAAAGGGAA ACGCAAATGA ATCTGCTGCA GAGGAGAGAG ACCAGGATAA GAAACGCAGA 
GTCGCAGGCA CAGAGAGTCG TGCCAGTCGT GCCGGAGAGT CTGTGGAGAA ACCTGAACGA 
GTAAGGCCAG GAACCCAGCT GTGTCAGGAA GAGCAAGGTG AACAGGAAGA TGACAGGAGA 
CCTCGACGTC AAACCAGAGA GCTAGCATCA AGGCGGAAAT CAAGGGAGGA CCCAGACAGA 
GAAGCAAGGC CAGGAACTCA CTTGGATGTG GACGATGACG ATGAAAAGGA CAAAAGAAGT 
TCCAGGCCCA GAAGCCAGCC CAGAGATCTA GCCACCAAAC GGAGACCCAA GGAAGAAGTA 
GAGCAGATCA CTCCAGAGCC TCCCGAGGGC AAAGATGAGG ACGAAAGGGA GGAGAAGAGA 
CGAAAAACGA CACGTAAAAA GCCGGAACCA CTCAGCATTC CCGTACAGAG CAGAGTGGAG 
AGAAAAGCCT CTCAGGGCAA AGCAAGTGCA ATCCCAAAGC TCAACCCGCC ACAGTGCCCT 
GAGTGTGGCC AGTACCTAGA TGACCCTGAC CTGAAGTACC AGCAGCACCC TGTGGATGCT 
GTGGATGAAC CCCAGATGCT GACCAATGAG GCACTGTCCG TCTTTGACTC CAACTCGTCT 
TGGTTTGAGA CCTATGATTC CTCTCCCATG CATAAGTTCA CTTTCTTCAG TGTGTATTGC 
AGTCGCGGTC ACTTGTGTCC TGTCGACACT GGTCTCATTG AGAAGAACGT TGAACTCTAC 
TTTTCTGGTG TTGCCAAAGC AATTCATGAA GAAAATCCGT CTGTGGAAGG TGGTGTTAAT 
GGCAAGAACC TGGGGCCAAT CAATCAGTGG TGGATCAGTG GCTTTGACGG TGGCGAGAAG 
GCGCTCATTG GCTTTTCTAC CGCATTTGCT GAATACTTTC TGATGGAGCC CAGCCCAGAG 
TATGCACCAA TATTTGGGCT GATGCAGGAG AAAATTTACA TCAGCAAGAT TGTGGTCGAG 
TTCTTGCAGA GCAATCCTGA CGCTGTCTAT GAAGACTTGA TCAATAAGAT CGAGACCACT 
GTTCCTCCTT CTGCCATCAA TGTGAACCGG TTCACCGAGG ACTCCCTCCT ACGCCATGCC 
CAGTTTGTGG TGAGCCAGGT AGAAAGTTAC GACGACGCTA AGGACGATGA TGAGACGCCC 
ATCTTCTTGT CTCCCTGTAT GAGGTCCCTG ATCCATTTGG CTGGTGTCTC GCTGGGACAG 
AGGCGAGCAA CAAGGCGCAC GGTCATCAAT TCTGCCAAAG TGAAGCGCAA GGGGCCCACA 
AAAGCCACCA CCACCAAGCT GGTCTATCAG ATCTTCGACA CTTTCTTCTC GGAGCAGATC 
GAGAAGGATG ACAAGGAGGA CAAAGAGAAC ACCATGAAGC GCCGCCGGTG TGGTGTCTGT 
GAGGTCTGTC AACAGCCTGA GTGTGGGAAG TGCAAGGCGT GCAAAGACAT GGTTAAGTTT 
GGTGGCACCG GACGGAGTAA ACAGGCTTGC CTCAAGAGGA GGTGTCCTAA CTTGGCCGTA 
AAGGAGGCAG ATGAAGACGA AGAAGCTGAT GATGATATAC CAGAGTTGCC GTCACCCAAA 
AAGTTGCACC AAGGGAAGAA GAAGAAACAG AATAAGGATC GCATCTCCTG GCTCGGGGAG 
CCTGTGAAGA TCGAAGAGAA CAGAACTTAC TATTGGAAGG TGAGCATCGA CGAAGAGACT 
CTGGAGGTGG GCGACTGCGT CTCGGTCATT CCGGATGATC CCTCCAAACC ACTGTATCTA 
GCCAGGGTCA CAGCACTGTG GGAAGACAAG AACGGGCAGA TGTTCCATGC ACACTGGTTC 
TGCGCGGGGA CAGACACGGT CCTCGGAGCC ACCTCTGACC CTCTGGAGCT GTTCCTTGTA 
GGCGAGTGTG AAAACATGCA ACTTTCCTAC ATCCACAGCA AGGTCAAGGT CATCTACAGA 
GGGCCTTCCC CAAACTGGGC CATGGAGGGA GGCATGGACC CTGAGGCCAT GTTGCCGGGG 
GCTGAGGATG GGAAGACCTA CTTCTACCAG TTCTGGTACA GCCAGGACTA CGCAAGGTTT 
GAGTCCCCAC CCAAGACCCA GCCGACGGAG GACAATAAGC ACAAGTTCTG CCTATCTTGT 
ATCCGGCTGG CTGAGCTGAG ACAAAAAGAA ATGCCCAAAG TCCTGGAACA ACTTGAGGAG 
GTGGACGGCC GGGTCTACTG CAGTTCTATC ACCAAGAACG GTGTTGTCTA CCGACTGGGT 
GACAGTGTGT ACCTGCCTCC TGAGGCCTTT ACTTTCAACA TCAAAATGGC CAGCCCCATG 
AAACGCTCTA AGAGGGACCC TGTGAATGAG AACCTGTACC CCGAGCATTA CCGCAAGTAT 
TCCGACTACA TCAAAGGAAG CAACCTGGAC GCCCCTGAAC CCTATCGGAT TGGTCGGATA 
AAAGAGATCC ACTGTGGCAA GAAGAAAGGT GGCAAGGTCA ATGAGGCAGA CATCAAGATC 
AGGCTCTACA AGTTCTATAG GCCTGAGAAC ACCCACAAGT CCATCCAGGC AACCTACCAC 
GCCGACATCA ACCTGCTCTA CTGGAGCGAT GAGGAAGCCG TGGTGGACTT CAGCGACGTG 
CAAGGCCGCT GCACCGTGGA GTACGGAGAG GACCTGCTTG AGAGCATCCA GGATTACTCA 
CAGGGCGGCC CCGACCGCTT CTACTTTCTC GAGGCCTACA ATTCAAAGAC TAAAAGCTTT 
GAAGACCCTC CGAACCATGC CCGCAGCCCT GGGAACAAAG GCAAAGGAAA GGGGAAAGGG 
AAAGGGAAGG GAAAACCTCA GGTATCAGAG CCCAAAGAGC CCGAGGCAGC CATCAAACTG 
CCTAAGCTGC GGACCCTGGA TGTGTTTTCT GGCTGTGGAG GATTAACAGA AGGATTCCAC 
CAAGCAGGCA TCTCGGAGAC GCTGTGGGCC ATCGAGATGT GGGAACCAGC AGCCCAGGCA 
TTTCGGCTGA ACAACCCTGG CACCACGGTG TTCACAGAGG ACTGCAACGT GCTTCTCAAG 
CTGGTCATGG CTGGTGAGGT GACCAACTCT CTGGGCCAGA GGCTGCCACA GAAGGGCGAT 
GTGGAGATGC TGTGTGGTGG GCCGCCCTGC CAGGGCTTCA GTGGCATGAA CCGTTTCAAC 
TCTCGTACTT ACTCCAAGTT CAAAAACTCC CTCGTGGTCT CCTTCCTCAG CTACTGTGAC 
TACTACCGGC CTCGGTTCTT CCTCTTGGAG AATGTCAGGA ACTTCGTGTC CTTCAGGCGC 
TCCATGGTGC TGAAGCTCAC ACTGCGCTGC CTGGTCCGCA TGGGCTACCA GTGCACCTTC 
GGTGTGCTCC AGGCTGGACA GTATGGTGTG GCCCAGACAC GAAGGAGGGC CATCATCTTG 
GCTGCAGCCC CTGGAGAGAA GCTGCCTCTG TTCCCAGAAC CTCTACACGT GTTTGCCCCC 
CGTGCCTGCC AGCTGAGTGT TGTGGTGGAC GACAAGAAGT TCGTTAGCAA CATTACAAGG 
CTAAGCTCGG GTCCCTTCCG AACCATCACG GTGCGAGATA CCATGTCTGA CCTCCCTGAG 
ATCCAGAATG GAGCCTCAGC CCCCGAGATC TCCTACAATG GAGAGCCACA GTCCTGGTTC 
CAGAGGCAGC TGCGAGGGTC GCACTACCAG CCCATCCTCA GGGACCATAT CTGCAAGGAC 
ATGAGCGCGC TGGTGGCTGC CCGTATGCGG CACATCCCGC TGTCCCCAGG ATCGGATTGG 
CGTGACCTGC CCAACATACA AGTGCGGCTG AGAGATGGCG TCATAACCAA TAAACTTCGC 
TACACTTTCC ACGACACGAA GAACGGCTGC AGCAGCACCG GGGCCCTGCG TGGGGTCTGC 
TCCTGTGCGG AAGGCAAGAC CTGCGACCCT GCTTCCAGAC AATTCAACAC GCTCATCCCC 
TGGTGCCTGC CGCACACTGG GAACCGGCAC AACCACTGGG CTGGCCTCTA CGGGCGTCTG 
GAGTGGGATG GCTTCTTCAG TACCACCGTC ACCAACCCTG AGCCCATGGG CAAGCAAGGC 
CGGGTGCTCC ATCCCGAGCA GCACCGGGTC GTGAGTGTGC GGGAATGTGC TCGCTCCCAA 
GGCTTTCCAG ATACCTACCG GTTATTCGGC AACATCCTGG ACAGACACCG GCAGGTGGGG 
AACGCTGTGC CACCACCACT GGCCAAAGCC ATCGGCCTGG AGATTAAGCT CTGTCTGCTG 
GCCAGCGCTC AGGAGAGTGC CTCAGCTGCA GTTAAAGGAA AGGAGGAGAC TACTACCGAG 
GACTAG