Cd40lg cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cd40lg
Entrez Gene ID	84349
Full Name	CD40 ligand
Synonyms	Cd40l,Tnfsf5
General protein information	Preferred Names CD40 ligand Names CD40 ligand CD40 ligand CD154 CD40-L tumor necrosis factor ligand superfamily member 5
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq37
Summary	CD40 ligand [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053353.1	NP_445805.1	CD40 ligand

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	CD40LG	NP_990064.1
Xenopus tropicalis (tropical clawed frog)	cd40lg	XP_002932670.1
Canis lupus familiaris (dog)	CD40LG	NP_001002981.1
Homo sapiens (human)	CD40LG	NP_000065.1
	CD40LG	NP_001028011.1
Bos taurus (cattle)	CD40LG	NP_777049.1
Rattus norvegicus (Norway rat)	Cd40lg	NP_445805.1
Pan troglodytes (chimpanzee)	CD40LG	XP_529175.2
Mus musculus (house mouse)	Cd40lg	NP_035746.2

Gene Ontology
Bibliography

Related articles in PubMed

Soluble CD40 ligand directly alters glomerular permeability and may act as a circulating permeability factor in FSGS.
Doublier S, Zennaro C, Musante L, Spatola T, Candiano G, Bruschi M, Besso L, Cedrino M, Carraro M, Ghiggeri GM, Camussi G, Lupia E
PloS one12(11)e0188045(2017)

The ginsenoside metabolite compound K exerts its anti-inflammatory activity by downregulating memory B cell in adjuvant-induced arthritis.
Chen J, Wang Q, Wu H, Liu K, Wu Y, Chang Y, Wei W
Pharmaceutical biology54(7)1280-8(2016 Jul)

Serum soluble CD40L concentration depending on the stage of multiple myeloma and its correlation with selected angiogenic cytokines.
Kami?ska J, Koper OM, Dymicka-Piekarska V, Motybel-Iwa?czuk E, O?dziej A, Kemona H
Polskie Archiwum Medycyny Wewnetrznej126(5)321-9(2016 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Soluble CD40 ligand directly alters glomerular permeability and may act as a circulating permeability factor in focal segmental glomerulosclerosis.
Title: Soluble CD40 ligand directly alters glomerular permeability and may act as a circulating permeability factor in FSGS.

These data suggest that placental ischemia-induced T-cell communication via the CD40L is one important mechanism leading to much of the pathophysiology of preeclampsia.
Title: Blockade of CD40 ligand for intercellular communication reduces hypertension, placental oxidative stress, and AT1-AA in response to adoptive transfer of CD4+ T lymphocytes from RUPP rats.

Suggest that CD154-CD40 T-cell co-stimulation pathway is a key mechanism in kidney ischemia-reperfusion injury.
Title: CD154-CD40 T-cell co-stimulation pathway is a key mechanism in kidney ischemia-reperfusion injury.

PSB33 functions in the maintenance of photosystem II-light-harvesting complex II.[PSB33]
Title: PHOTOSYSTEM II PROTEIN33, a protein conserved in the plastid lineage, is associated with the chloroplast thylakoid membrane and provides stability to photosystem II supercomplexes in Arabidopsis.

CD40/CD40L and IkappaB/NF-kappaB pathways could effectively extend the survival of islet grafts
Title: Simultaneous blockade of the CD40/CD40L and NF-?B pathways prolonged islet allograft survival.

The following Cd40lg gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cd40lg cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09338	NM_053353.1 Latest version!	Rattus norvegicus CD40 ligand (Cd40lg), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cd40lg ( NM_053353.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_445805.1 Rattus norvegicus CD40 ligand (Cd40lg), mRNA.

Price & Availability↑

CloneID	ORa09338
Clone ID Related Accession (Same CDS sequence)	NM_053353.1
Accession Version	NM_053353.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 783bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Rattus norvegicus(Norway rat)
Product	CD40 ligand
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF116582.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF013985.1, AF116582.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689594, SAMEA2689599 [ECO:0000348] ##Evidence-Data-END##

ATGATAGAAA CATACAGCCA ACCTTCTCCC AGATCTGTGG CTACTGGGCT TCCAGCGAGC 
ATGAAGATTT TTATGTATTT ACTTACTGTT TTTCTTATCA CCCAGATGAT TGGGTCGGTG 
CCTTTTGCTG TGTATCTTCA TAGAAGATTG GATAAGGTAG AGGAGGAAGC AAGCCTTCAC 
GAGGATTTTG TATTCGTAAA AAAGCTAAAG AGGTGCAACA AAGGAGAAGG GTCCTTATCC 
TTGCTCAACT GTGAGGAGAT GAGAAGGCAA TTTGAAGACC TTGTCAAGGA TATATCGTTA 
AACAAAGAAG AGAAAAAAGA AAAGAGCTTT GAAATGCAAA GAGGTGATGA GGATCCTCAA 
ATTGCAGCAC ATGTTGTAAG TGAGGCCAAC AGTAATGCAG CATCTGTTCT TCAGTGGGCG 
AAGAAAGGAT ATTATACCAT GAAAAGCAAC TTGGTAGTGC TGGAAAATGG GAGACAACTG 
ACGGTTAAAA GAGAAGGACT CTATTATGTC TACACCCAAG TCACCTTCTG CTCTAATCGG 
GAACCTTTGA GTCAACGTCC ATTCATCGTC AGCCTCTGGC TGAAGCCCAG CAGTGGGTCA 
GAGAGAATCT TACTCAGGGC AGCGAATACC CACAGTTCCT CCAAGCTTTG TGAGCAACAG 
TCCATTCACT TGGGCGGAGT ATTTGAATTA CAAGCAGGTG CTTCTGTGTT TGTCAACGTG 
ACTGAAGCAA GCCAAGTGAT CCACGGAATT GGCTTCTCAT CTATTGGCTT ACTCAAACTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_445805.1
CDS	1..783
Translation	MIETYSQPSPRSVATGLPASMKIFMYLLTVFLITQMIGSVPFAVYLHRRLDKVEEEASLHEDFVFVKKLKRCNKGEGSLSLLNCEEMRRQFEDLVKDISLNKEEKKEKSFEMQRGDEDPQIAAHVVSEANSNAASVLQWAKKGYYTMKSNLVVLENGRQLTVKREGLYYVYTQVTFCSNREPLSQRPFIVSLWLKPSSGSERILLRAANTHSSSKLCEQQSIHLGGVFELQAGASVFVNVTEASQVIHGIGFSSIGLLKL

Target ORF information:

RefSeq Version	NM_053353.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus CD40 ligand (Cd40lg), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053353.1

ORF Insert Sequence:

ATGATAGAAA CATACAGCCA ACCTTCTCCC AGATCTGTGG CTACTGGGCT TCCAGCGAGC 
ATGAAGATTT TTATGTATTT ACTTACTGTT TTTCTTATCA CCCAGATGAT TGGGTCGGTG 
CCTTTTGCTG TGTATCTTCA TAGAAGATTG GATAAGGTAG AGGAGGAAGC AAGCCTTCAC 
GAGGATTTTG TATTCGTAAA AAAGCTAAAG AGGTGCAACA AAGGAGAAGG GTCCTTATCC 
TTGCTCAACT GTGAGGAGAT GAGAAGGCAA TTTGAAGACC TTGTCAAGGA TATATCGTTA 
AACAAAGAAG AGAAAAAAGA AAAGAGCTTT GAAATGCAAA GAGGTGATGA GGATCCTCAA 
ATTGCAGCAC ATGTTGTAAG TGAGGCCAAC AGTAATGCAG CATCTGTTCT TCAGTGGGCG 
AAGAAAGGAT ATTATACCAT GAAAAGCAAC TTGGTAGTGC TGGAAAATGG GAGACAACTG 
ACGGTTAAAA GAGAAGGACT CTATTATGTC TACACCCAAG TCACCTTCTG CTCTAATCGG 
GAACCTTTGA GTCAACGTCC ATTCATCGTC AGCCTCTGGC TGAAGCCCAG CAGTGGGTCA 
GAGAGAATCT TACTCAGGGC AGCGAATACC CACAGTTCCT CCAAGCTTTG TGAGCAACAG 
TCCATTCACT TGGGCGGAGT ATTTGAATTA CAAGCAGGTG CTTCTGTGTT TGTCAACGTG 
ACTGAAGCAA GCCAAGTGAT CCACGGAATT GGCTTCTCAT CTATTGGCTT ACTCAAACTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Soluble CD40 ligand directly alters glomerular permeability and may act as a circulating permeability factor in FSGS.
PloS one12(11)e0188045(2017)
Doublier S,Zennaro C,Musante L,Spatola T,Candiano G,Bruschi M,Besso L,Cedrino M,Carraro M,Ghiggeri GM,Camussi G,Lupia E

The ginsenoside metabolite compound K exerts its anti-inflammatory activity by downregulating memory B cell in adjuvant-induced arthritis.
Pharmaceutical biology54(7)1280-8(2016 Jul)
Chen J,Wang Q,Wu H,Liu K,Wu Y,Chang Y,Wei W

Serum soluble CD40L concentration depending on the stage of multiple myeloma and its correlation with selected angiogenic cytokines.
Polskie Archiwum Medycyny Wewnetrznej126(5)321-9(2016 May)
Kami?ska J,Koper OM,Dymicka-Piekarska V,Motybel-Iwa?czuk E,O?dziej A,Kemona H