Sdcbp cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sdcbp
Entrez Gene ID	83841
Full Name	syndecan binding protein
Synonyms	TACIP18,mda-9
General protein information	Preferred Names syndecan binding protein Names syntenin-1 syndecan-binding protein 1 syntenin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q12
Summary	a neurofascin-binding protein [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031986.1	NP_114192.1	syntenin-1

Pathways from BioSystems

Homologies

Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009569	XP_318581.1
Pan troglodytes (chimpanzee)	SDCBP	NP_001233375.1
	SDCBP	XP_001088209.2
Homo sapiens (human)	SDCBP	NP_005616.2
Rattus norvegicus (Norway rat)	Sdcbp	NP_114192.1
Gallus gallus (chicken)	SDCBP	NP_001026195.1
Canis lupus familiaris (dog)	SDCBP	XP_005638059.1
Bos taurus (cattle)	SDCBP	NP_001068951.1
Mus musculus (house mouse)	Sdcbp	NP_001091697.1
Danio rerio (zebrafish)	sdcbp	NP_997856.1
Xenopus tropicalis (tropical clawed frog)	sdcbp	NP_001006801.1

Gene Ontology
Bibliography

Related articles in PubMed

New structural insight of C-terminal region of Syntenin-1, enhancing the molecular dimerization and inhibitory function related on Syndecan-4 signaling.
Choi Y, Yun JH, Yoo J, Lee I, Kim H, Son HN, Kim IS, Yoon HS, Zimmermann P, Couchman JR, Cho HS, Oh ES, Lee W
Scientific reports636818(2016 Nov)

Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling.
Egea-Jimenez AL, Gallardo R, Garcia-Pino A, Ivarsson Y, Wawrzyniak AM, Kashyap R, Loris R, Schymkowitz J, Rousseau F, Zimmermann P
Nature communications712101(2016 Jul)

Syntenin regulates TGF-?1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-? type I receptor internalization.
Hwangbo C, Tae N, Lee S, Kim O, Park OK, Kim J, Kwon SH, Lee JH
Oncogene35(3)389-401(2016 Jan)

Syntenin controls migration, growth, proliferation, and cell cycle progression in cancer cells.
Kashyap R, Roucourt B, Lembo F, Fares J, Carcavilla AM, Restouin A, Zimmermann P, Ghossoub R
Frontiers in pharmacology6241(2015)

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S, Zaidel-Bar R
Science signaling7(354)rs7(2014 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Syntenin-1 may contribute to the molecular organization of presynaptic active zones by linking ERC2 and other cytoskeletal matrix components to diverse syntenin-1-associated synaptic proteins.
Title: Organization of the presynaptic active zone by ERC2/CAST1-dependent clustering of the tandem PDZ protein syntenin-1.

Syntenin is involved in controlling neuronal membrane organization, and by its interaction with kainate receptors, syntenin may play a role in determining the formation and maturation of synapses.
Title: Syntenin is involved in the developmental regulation of neuronal membrane architecture.

Syntenin-1 may be an in vivo binding partner of GlyT2 that regulates its trafficking and/or presynaptic localization in glycinergic neurons.
Title: The neuronal glycine transporter 2 interacts with the PDZ domain protein syntenin-1.

The following Sdcbp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sdcbp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08916	NM_031986.1 Latest version!	Rattus norvegicus syndecan binding protein (Sdcbp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sdcbp ( NM_031986.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_114192.1 Rattus norvegicus syndecan binding protein (Sdcbp), mRNA.

Price & Availability↑

CloneID	ORa08916
Clone ID Related Accession (Same CDS sequence)	NM_031986.1
Accession Version	NM_031986.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 903bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Rattus norvegicus(Norway rat)
Product	syntenin-1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF248548.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF248548.1, BC064651.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTCTCTCT ATCCATCTCT TGAAGATTTG AAGGTAGACA AAGTAATTCA GGCTCAAACT 
GCCTCTTCTG CTAATCCTGC CAGCCAGGCC TTTTTTTTAA ATGTGGTCGA TTCTGCTGCC 
TTCCCTCCAG GTGGAAATCT CTATCCTAAA CTGTATCCAG AACTCTCTCA ATACATGGGA 
CTGTCTTTAA GTGAAGCTGA AATATGTGAA AACATGCCTG TGGTCTCTGG AGCGCCAACC 
CAAGGGCAGT TGGTAGCAAG GCCATCCAGT GTGAACTACA TGGTAGCACC TGTGACAGGT 
AACGATGCGG GGATTAGGAG AGCAGAGATT AAGCAAGGGA TTCGGGAAGT CATTTTGTGT 
AAGGATCAAG ATGGAAAAAT TGGGCTCAGA CTGAAGTCAG TAGATAATGG TATATTTGTT 
CAACTAGTCC AGGCTAATTC CCCAGCCTCC TTGGTTGGGC TGCGATTTGG GGACCAGGTG 
CTCCAGATCA ATGGTGAAAA CTGTGCCGGC TGGAGCTCCG ATAAGGCACA CAAGGTGCTC 
AAGCAGGCCT TTGGAGAGAA GATTACCATG ACCATTCGTG ATAGACCCTT TGAACGGACA 
GTTACCATGC ATAAGGACAG CAGTGGACAT GTTGGCTTTA TCTTTAAAAG TGGAAAAATC 
ACATCCATAG TGAAAGACAG TTCTGCTGCC AGAAACGGCC TTCTCACTGA TCACCACATC 
TGTGAGATCA ACGGACAGAA CGTCATTGGC TTGAAGGATG CTCAGATTGC AGATATACTG 
TCAACAGCTG GGACTGTGGT CACCATCACA ATCATGCCTG CCTTTATCTT CGAACATATT 
ATTAAACGGA TGGCTCCCAG CATTATGAAA AGCCTGATGG ATCACACCAT TCCTGAAGTT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114192.1
CDS	73..975
Translation	MSLYPSLEDLKVDKVIQAQTASSANPASQAFFLNVVDSAAFPPGGNLYPKLYPELSQYMGLSLSEAEICENMPVVSGAPTQGQLVARPSSVNYMVAPVTGNDAGIRRAEIKQGIREVILCKDQDGKIGLRLKSVDNGIFVQLVQANSPASLVGLRFGDQVLQINGENCAGWSSDKAHKVLKQAFGEKITMTIRDRPFERTVTMHKDSSGHVGFIFKSGKITSIVKDSSAARNGLLTDHHICEINGQNVIGLKDAQIADILSTAGTVVTITIMPAFIFEHIIKRMAPSIMKSLMDHTIPEV

Target ORF information:

RefSeq Version	NM_031986.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus syndecan binding protein (Sdcbp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031986.1

ORF Insert Sequence:

ATGTCTCTCT ATCCATCTCT TGAAGATTTG AAGGTAGACA AAGTAATTCA GGCTCAAACT 
GCCTCTTCTG CTAATCCTGC CAGCCAGGCC TTTTTTTTAA ATGTGGTCGA TTCTGCTGCC 
TTCCCTCCAG GTGGAAATCT CTATCCTAAA CTGTATCCAG AACTCTCTCA ATACATGGGA 
CTGTCTTTAA GTGAAGCTGA AATATGTGAA AACATGCCTG TGGTCTCTGG AGCGCCAACC 
CAAGGGCAGT TGGTAGCAAG GCCATCCAGT GTGAACTACA TGGTAGCACC TGTGACAGGT 
AACGATGCGG GGATTAGGAG AGCAGAGATT AAGCAAGGGA TTCGGGAAGT CATTTTGTGT 
AAGGATCAAG ATGGAAAAAT TGGGCTCAGA CTGAAGTCAG TAGATAATGG TATATTTGTT 
CAACTAGTCC AGGCTAATTC CCCAGCCTCC TTGGTTGGGC TGCGATTTGG GGACCAGGTG 
CTCCAGATCA ATGGTGAAAA CTGTGCCGGC TGGAGCTCCG ATAAGGCACA CAAGGTGCTC 
AAGCAGGCCT TTGGAGAGAA GATTACCATG ACCATTCGTG ATAGACCCTT TGAACGGACA 
GTTACCATGC ATAAGGACAG CAGTGGACAT GTTGGCTTTA TCTTTAAAAG TGGAAAAATC 
ACATCCATAG TGAAAGACAG TTCTGCTGCC AGAAACGGCC TTCTCACTGA TCACCACATC 
TGTGAGATCA ACGGACAGAA CGTCATTGGC TTGAAGGATG CTCAGATTGC AGATATACTG 
TCAACAGCTG GGACTGTGGT CACCATCACA ATCATGCCTG CCTTTATCTT CGAACATATT 
ATTAAACGGA TGGCTCCCAG CATTATGAAA AGCCTGATGG ATCACACCAT TCCTGAAGTT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

New structural insight of C-terminal region of Syntenin-1, enhancing the molecular dimerization and inhibitory function related on Syndecan-4 signaling.
Scientific reports636818(2016 Nov)
Choi Y,Yun JH,Yoo J,Lee I,Kim H,Son HN,Kim IS,Yoon HS,Zimmermann P,Couchman JR,Cho HS,Oh ES,Lee W

Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling.
Nature communications712101(2016 Jul)
Egea-Jimenez AL,Gallardo R,Garcia-Pino A,Ivarsson Y,Wawrzyniak AM,Kashyap R,Loris R,Schymkowitz J,Rousseau F,Zimmermann P

Syntenin regulates TGF-?1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-? type I receptor internalization.
Oncogene35(3)389-401(2016 Jan)
Hwangbo C,Tae N,Lee S,Kim O,Park OK,Kim J,Kwon SH,Lee JH

Syntenin controls migration, growth, proliferation, and cell cycle progression in cancer cells.
Frontiers in pharmacology6241(2015)
Kashyap R,Roucourt B,Lembo F,Fares J,Carcavilla AM,Restouin A,Zimmermann P,Ghossoub R

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Science signaling7(354)rs7(2014 Dec)
Guo Z,Neilson LJ,Zhong H,Murray PS,Zanivan S,Zaidel-Bar R