Gabbr2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gabbr2
Entrez Gene ID	83633
Full Name	gamma-aminobutyric acid type B receptor subunit 2
Synonyms	Gpr51
General protein information	Preferred Names gamma-aminobutyric acid type B receptor subunit 2 Names gamma-aminobutyric acid type B receptor subunit 2 G-protein coupled receptor 51 GABA-B R2 receptor GABA-B receptor 2 GABA-B-R2 GABA-BR2 GABABR2 gamma-aminobutyric acid (GABA) B receptor 2 gb2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q22
Summary	combines with GABA-B1 to form functional GABA-B receptors; inhibits high voltage activated calcium ion channels [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031802.1	NP_113990.1	gamma-aminobutyric acid type B receptor subunit 2 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	GABBR2	NP_005449.5
Drosophila melanogaster (fruit fly)	GABA-B-R2	NP_732658.1
Xenopus tropicalis (tropical clawed frog)	gabbr2	NP_001016007.2
Canis lupus familiaris (dog)	GABBR2	XP_538749.2
Mus musculus (house mouse)	Gabbr2	NP_001074610.1
Rattus norvegicus (Norway rat)	Gabbr2	NP_113990.1
Anopheles gambiae (African malaria mosquito)	GPRGBB2	XP_557488.3
Caenorhabditis elegans (roundworm)	gbb-2	NP_500579.3
Pan troglodytes (chimpanzee)	GABBR2	XP_520146.2
Bos taurus (cattle)	GABBR2	XP_002689780.1
Gallus gallus (chicken)	GABBR2	XP_419066.3
Danio rerio (zebrafish)	gabbr2	NP_001137515.1

Gene Ontology
Bibliography

Related articles in PubMed

Activation of GABAB2 subunits alleviates chronic cerebral hypoperfusion-induced anxiety-like behaviours: A role for BDNF signalling and Kir3 channels.
Lu Y, Li CJ, Chen C, Luo P, Zhou M, Li C, Xu XL, Lu Q, He Z, Guo LJ
Neuropharmacology110(Pt A)308-321(2016 Nov)

Differential regulation of GABAB receptor trafficking by different modes of N-methyl-D-aspartate (NMDA) receptor signaling.
Kantamneni S, Gonz?lez-Gonz?lez IM, Luo J, Cimarosti H, Jacobs SC, Jaafari N, Henley JM
The Journal of biological chemistry289(10)6681-94(2014 Mar)

Post-transcriptional regulation of GABAB receptor and GIRK1 channels by Nogo receptor 1.
Murthy R, Kim J, Sun X, Giger RJ, Fink DJ, Mata M
Molecular brain630(2013 Jul)

Non-hyperpolarizing GABAB receptor activation regulates neuronal migration and neurite growth and specification by cAMP/LKB1.
Bony G, Szczurkowska J, Tamagno I, Shelly M, Contestabile A, Cancedda L
Nature communications41800(2013)

Plasma membrane density of GABA(B)-R1a, GABA(B)-R1b, GABA-R2 and trimeric G-proteins in the course of postnatal development of rat brain cortex.
Dlouh? K, Kagan D, Roubalov? L, Uj??kov? H, Svoboda P
Physiological research62(5)547-59(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study shows that the trafficking and surface expression of GABABR2 and GABABR1 is differentially regulated by synaptic or pathophysiological activation of NMDA receptors.
Title: Differential regulation of GABAB receptor trafficking by different modes of N-methyl-D-aspartate (NMDA) receptor signaling.

siRNA knock-down of NgR1 resulted in a selective increase of GABAB R1 and GABAB R2 protein and an increase in GIRK1.
Title: Post-transcriptional regulation of GABAB receptor and GIRK1 channels by Nogo receptor 1.

GABABR activation reduces cyclic AMP-dependent phosphorylation of LKB1, a kinase involved in neuronal polarization, and rescues LKB1 overexpression-induced defects in cortical development.
Title: Non-hyperpolarizing GABAB receptor activation regulates neuronal migration and neurite growth and specification by cAMP/LKB1.

Gabbr2 exists in rat brain at birth and decreases between birth and PD15.
Title: Plasma membrane density of GABA(B)-R1a, GABA(B)-R1b, GABA-R2 and trimeric G-proteins in the course of postnatal development of rat brain cortex.

GABA(B)R2 proteins are reduced in the prefrontal cortex of aged rats but these reductions are not associated with spatial learning abilities.
Title: GABA(B) receptor GTP-binding is decreased in the prefrontal cortex but not the hippocampus of aged rats.

The following Gabbr2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gabbr2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08769	NM_031802.1 Latest version!	Rattus norvegicus gamma-aminobutyric acid type B receptor subunit 2 (Gabbr2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	Quote Price

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gabbr2 ( NM_031802.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113990.1 Rattus norvegicus gamma-aminobutyric acid type B receptor subunit 2 (Gabbr2), mRNA.

Price & Availability↑

CloneID	ORa08769
Clone ID Related Accession (Same CDS sequence)	NM_031802.1
Accession Version	NM_031802.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2823bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	gamma-aminobutyric acid type B receptor subunit 2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF058795.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF058795.1, AF109405.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCTTCCC CGCCGAGCTC CGGGCAGCCC CGGCCGCCGC CGCCGCCGCC GCCGCCCGCG 
CGCCTGCTGC TGCCCCTGCT GCTGTCGCTG CTGCTGTGGT TGGCGCCCGG GGCCTGGGGC 
TGGACGCGGG GCGCCCCCCG GCCGCCGCCC AGCAGCCCGC CGCTCTCCAT CATGGGCCTC 
ATGCCGCTCA CCAAGGAGGT GGCCAAGGGC AGCATCGGGC GCGGCGTGCT CCCCGCCGTG 
GAGCTAGCCA TCGAGCAGAT CCGCAACGAG TCACTCCTGC GCCCCTACTT CCTGGACCTG 
CGACTCTATG ACACCGAGTG TGACAATGCA AAGGGACTGA AAGCCTTCTA TGACGCAATA 
AAGTATGGGC CGAACCATTT GATGGTGTTT GGAGGCGTCT GTCCGTCTGT CACATCTATT 
ATCGCGGAGT CCCTCCAAGG CTGGAATCTG GTGCAGCTTT CCTTCGCCGC CACCACGCCT 
GTTCTTGCGG ATAAGAAGAA GTACCCGTAT TTCTTCCGGA CGGTGCCGTC AGACAACGCG 
GTGAACCCCG CCATCCTGAA GCTCCTGAAG CACTTCCGCT GGCGGCGTGT GGGCACACTC 
ACGCAGGACG YGCAGCGCTT CTCCGAGGTG AGGAATGACC TGACTGGGGT TCTGTATGGG 
GAAGATATTG AGATCTCAGA CACAGAGAGT TTCTCCAATG ATCCCTGCAC CAGCGTCAAA 
AAGCTCAAGG GGAATGACGT GCGGATCATC CTTGGCCAGT TTGACCAGAA TATGGCAGCA 
AAAGTCTTCT GTTGTGCCTT CGAGGAGAGC ATGTTTGGCA GCAAGTACCA GTGGATCATC 
CCGGGATGGT ACGAGCCTGC GTGGTGGGAG CAGGTGCATG TGGAGGCCAA TTCCTCACGC 
TGCCTGCGCA GAAGCCTCCT GGCTGCCATG GAAGGTTACA TCGGAGTGGA CTTTGAGCCC 
CTGAGCTCCA AACAAATCAA GACCATCTCA GGGAAGACTC CACAGCAGTT TGAAAGAGAG 
TACAACAGCA AACGTTCAGG CGTGGGGCCC AGCAAGTTCC ATGGGTACGC CTACGATGGG 
ATCTGGGTCA TCGCCAAGAC CCTACAGAGG GCCATGGAGA CACTGCATGC CAGTAGCAGG 
CACCAGCGGA TCCAGGACTT CAACTACACA GACCACACGC TGGGCAAAAT CATCCTCAAT 
GCCATGAACG AGACCAACTT CTTCGGGGTC ACGGGTCAAG TTGTGTTCCG GAACGGGGAG 
AGAATGGGAA CCATTAAATT TACTCAATTT CAAGACAGCA GAGAGGTGAA GGTCGGCGAA 
TACAACGCGG TGGCTGACAC ACTGGAGATC ATCAATGACA CCATAAGGTT CCAGGGGTCC 
GAGCCACCCA AGGACAAGAC CATCATTCTG GAGCAGCTTC GGAAGATCTC GCTTCCACTG 
TATAGCATCC TGTCCGCTCT CACCATCCTC GGCATGATCA TGGCCAGCGC CTTCCTCTTC 
TTCAACATCA AGAACCGGAA CCAAAAGCTG ATTAAGATGT CAAGCCCCTA CATGAACAAC 
CTCATCATCC TGGGAGGAAT GCTGTCCTAT GCATCCATCT TCCTCTTTGG CCTCGACGGG 
TCCTTCGTCT CAGAAAAGAC CTTTGAAACA CTCTGCACGG TCCGGACCTG GATTCTCACC 
GTGGGCTACA CAACTGCCTT TGGGGCCATG TTTGCAAAGA CCTGGAGGGT CCATGCCATC 
TTCAAAAATG TGAAGATGAA GAAGAAGATC ATCAAAGACC AGAAGCTGCT TGTGATTGTG 
GGGGGCATGC TGCTCATCGA CCTGTGCATC CTGATCTGTT GGCAGGCTGT GGACCCCCTG 
CGGAGGACAG TGGAGAGGTA CAGCATGGAG CCGGACCCAG CAGGCCGGGA CATCTCCATC 
CGCCCATTGC TGGAACACTG CGAAAACACC CACATGACCA TCTGGCTTGG CATTGTCTAC 
GCCTACAAGG GGCTCCTCAT GCTATTCGGT TGTTTCTTGG CATGGGAAAC CCGCAATGTG 
AGCATCCCTG CCCTCAACGA CAGCAAGTAC ATCGGCATGA GTGTGTACAA TGTGGGGATC 
ATGTGCATCA TCGGGGCTGC TGTCTCCTTC CTGACGCGTG ACCAGCCCAA CGTGCAGTTC 
TGCATCGTGG CCCTGGTCAT CATCTTCTGC AGCACCATCA CTCTCTGCCT GGTGTTTGTG 
CCAAAGCTCA TCACTCTGAG GACAAACCCT GACGCAGCCA CTCAGAACAG GCGGTTCCAG 
TTCACACAGA ACCAGAAGAA AGAAGATTCG AAGACCTCCA CTTCAGTCAC CAGCGTGAAC 
CAGGCGAGCA CGTCACGCCT GGAGGGACTG CAGTCAGAAA ACCACCGCCT TCGAATGAAG 
ATCACAGAGC TGGACAAAGA CTTGGAAGAA GTCACCATGC AGCTACAAGA CACACCAGAG 
AAGACCACAT ACATCAAACA GAATCACTAC CAAGAGCTCA ACGACATCCT CAGCTTGGGC 
AACTTCACAG AGAGCACAGA TGGAGGAAAG GCCATTCTAA AAAATCACCT CGATCAAAAC 
CCCCAGCTCC AGTGGAACAC GACAGAGCCC TCAAGAACAT GCAAAGACCC CATAGAAGAC 
ATCAACTCCC CGGAGCACAT CCAGCGCCGG CTGTCGCTCC AGCTCCCCAT CCTTCACCAC 
GCCTACCTCC CATCCATCGG AGGCGTGGAT GCCAGCTGCG TCAGCCCCTG TGTCAGCCCT 
ACCGCCAGCC CTCGCCACAG ACACGTACCA CCCTCCTTCC GAGTCATGGT CTCGGGCCTG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113990.1
CDS	151..2973
Translation	MASPPSSGQPRPPPPPPPPARLLLPLLLSLLLWLAPGAWGWTRGAPRPPPSSPPLSIMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHFRWRRVGTLTQDnullQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAFEESMFGSKYQWIIPGWYEPAWWEQVHVEANSSRCLRRSLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQFEREYNSKRSGVGPSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGKIILNAMNETNFFGVTGQVVFRNGERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVERYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILSLGNFTESTDGGKAILKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILHHAYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMVSGL

Target ORF information:

RefSeq Version	NM_031802.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus gamma-aminobutyric acid type B receptor subunit 2 (Gabbr2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031802.1

ORF Insert Sequence:

ATGGCTTCCC CGCCGAGCTC CGGGCAGCCC CGGCCGCCGC CGCCGCCGCC GCCGCCCGCG 
CGCCTGCTGC TGCCCCTGCT GCTGTCGCTG CTGCTGTGGT TGGCGCCCGG GGCCTGGGGC 
TGGACGCGGG GCGCCCCCCG GCCGCCGCCC AGCAGCCCGC CGCTCTCCAT CATGGGCCTC 
ATGCCGCTCA CCAAGGAGGT GGCCAAGGGC AGCATCGGGC GCGGCGTGCT CCCCGCCGTG 
GAGCTAGCCA TCGAGCAGAT CCGCAACGAG TCACTCCTGC GCCCCTACTT CCTGGACCTG 
CGACTCTATG ACACCGAGTG TGACAATGCA AAGGGACTGA AAGCCTTCTA TGACGCAATA 
AAGTATGGGC CGAACCATTT GATGGTGTTT GGAGGCGTCT GTCCGTCTGT CACATCTATT 
ATCGCGGAGT CCCTCCAAGG CTGGAATCTG GTGCAGCTTT CCTTCGCCGC CACCACGCCT 
GTTCTTGCGG ATAAGAAGAA GTACCCGTAT TTCTTCCGGA CGGTGCCGTC AGACAACGCG 
GTGAACCCCG CCATCCTGAA GCTCCTGAAG CACTTCCGCT GGCGGCGTGT GGGCACACTC 
ACGCAGGACG YGCAGCGCTT CTCCGAGGTG AGGAATGACC TGACTGGGGT TCTGTATGGG 
GAAGATATTG AGATCTCAGA CACAGAGAGT TTCTCCAATG ATCCCTGCAC CAGCGTCAAA 
AAGCTCAAGG GGAATGACGT GCGGATCATC CTTGGCCAGT TTGACCAGAA TATGGCAGCA 
AAAGTCTTCT GTTGTGCCTT CGAGGAGAGC ATGTTTGGCA GCAAGTACCA GTGGATCATC 
CCGGGATGGT ACGAGCCTGC GTGGTGGGAG CAGGTGCATG TGGAGGCCAA TTCCTCACGC 
TGCCTGCGCA GAAGCCTCCT GGCTGCCATG GAAGGTTACA TCGGAGTGGA CTTTGAGCCC 
CTGAGCTCCA AACAAATCAA GACCATCTCA GGGAAGACTC CACAGCAGTT TGAAAGAGAG 
TACAACAGCA AACGTTCAGG CGTGGGGCCC AGCAAGTTCC ATGGGTACGC CTACGATGGG 
ATCTGGGTCA TCGCCAAGAC CCTACAGAGG GCCATGGAGA CACTGCATGC CAGTAGCAGG 
CACCAGCGGA TCCAGGACTT CAACTACACA GACCACACGC TGGGCAAAAT CATCCTCAAT 
GCCATGAACG AGACCAACTT CTTCGGGGTC ACGGGTCAAG TTGTGTTCCG GAACGGGGAG 
AGAATGGGAA CCATTAAATT TACTCAATTT CAAGACAGCA GAGAGGTGAA GGTCGGCGAA 
TACAACGCGG TGGCTGACAC ACTGGAGATC ATCAATGACA CCATAAGGTT CCAGGGGTCC 
GAGCCACCCA AGGACAAGAC CATCATTCTG GAGCAGCTTC GGAAGATCTC GCTTCCACTG 
TATAGCATCC TGTCCGCTCT CACCATCCTC GGCATGATCA TGGCCAGCGC CTTCCTCTTC 
TTCAACATCA AGAACCGGAA CCAAAAGCTG ATTAAGATGT CAAGCCCCTA CATGAACAAC 
CTCATCATCC TGGGAGGAAT GCTGTCCTAT GCATCCATCT TCCTCTTTGG CCTCGACGGG 
TCCTTCGTCT CAGAAAAGAC CTTTGAAACA CTCTGCACGG TCCGGACCTG GATTCTCACC 
GTGGGCTACA CAACTGCCTT TGGGGCCATG TTTGCAAAGA CCTGGAGGGT CCATGCCATC 
TTCAAAAATG TGAAGATGAA GAAGAAGATC ATCAAAGACC AGAAGCTGCT TGTGATTGTG 
GGGGGCATGC TGCTCATCGA CCTGTGCATC CTGATCTGTT GGCAGGCTGT GGACCCCCTG 
CGGAGGACAG TGGAGAGGTA CAGCATGGAG CCGGACCCAG CAGGCCGGGA CATCTCCATC 
CGCCCATTGC TGGAACACTG CGAAAACACC CACATGACCA TCTGGCTTGG CATTGTCTAC 
GCCTACAAGG GGCTCCTCAT GCTATTCGGT TGTTTCTTGG CATGGGAAAC CCGCAATGTG 
AGCATCCCTG CCCTCAACGA CAGCAAGTAC ATCGGCATGA GTGTGTACAA TGTGGGGATC 
ATGTGCATCA TCGGGGCTGC TGTCTCCTTC CTGACGCGTG ACCAGCCCAA CGTGCAGTTC 
TGCATCGTGG CCCTGGTCAT CATCTTCTGC AGCACCATCA CTCTCTGCCT GGTGTTTGTG 
CCAAAGCTCA TCACTCTGAG GACAAACCCT GACGCAGCCA CTCAGAACAG GCGGTTCCAG 
TTCACACAGA ACCAGAAGAA AGAAGATTCG AAGACCTCCA CTTCAGTCAC CAGCGTGAAC 
CAGGCGAGCA CGTCACGCCT GGAGGGACTG CAGTCAGAAA ACCACCGCCT TCGAATGAAG 
ATCACAGAGC TGGACAAAGA CTTGGAAGAA GTCACCATGC AGCTACAAGA CACACCAGAG 
AAGACCACAT ACATCAAACA GAATCACTAC CAAGAGCTCA ACGACATCCT CAGCTTGGGC 
AACTTCACAG AGAGCACAGA TGGAGGAAAG GCCATTCTAA AAAATCACCT CGATCAAAAC 
CCCCAGCTCC AGTGGAACAC GACAGAGCCC TCAAGAACAT GCAAAGACCC CATAGAAGAC 
ATCAACTCCC CGGAGCACAT CCAGCGCCGG CTGTCGCTCC AGCTCCCCAT CCTTCACCAC 
GCCTACCTCC CATCCATCGG AGGCGTGGAT GCCAGCTGCG TCAGCCCCTG TGTCAGCCCT 
ACCGCCAGCC CTCGCCACAG ACACGTACCA CCCTCCTTCC GAGTCATGGT CTCGGGCCTG 
TAG