Tceb2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tceb2
Entrez Gene ID	81807
Full Name	elongin B
Synonyms	Tceb2
General protein information	Preferred Names elongin B Names elongin-B transcription elongation factor B polypeptide 2 RNA polymerase II transcription factor SIII subunit B SIII p18 elongin 18 kDa subunit transcription elongation factor B (SIII) polypeptide 2 (18kD, elongin B) transcription elongation factor B (SIII), polypeptide 2 transcription elongation factor B subunit 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q12
Summary	positive regulatory subunit of the general transcription factor SIII heterotrimer; acts to increast the rate of RNA polymerase II transcription; regulates RNA polymerase II elongation complex activity [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031129.3	NP_112391.1	elongin-B
XM_008767596.1	XP_008765818.1	transcription elongation factor B polypeptide 2 isoform X1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	LOC101906273	XP_005202449.1
Rattus norvegicus (Norway rat)	Tceb2	NP_112391.1
Pan troglodytes (chimpanzee)	LOC739191	XP_001148528.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003154	XP_312844.5
Mus musculus (house mouse)	Tceb2	NP_080581.1
Danio rerio (zebrafish)	tceb2	NP_001136426.1
Drosophila melanogaster (fruit fly)	Elongin-B	NP_524416.1
Xenopus tropicalis (tropical clawed frog)	tceb2	NP_988962.1

Gene Ontology
Bibliography

Related articles in PubMed

Regulation of oxygen homeostasis by hypoxia-inducible factor 1.
Semenza GL
Physiology (Bethesda, Md.)2497-106(2009 Apr)

ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism.
Ferguson JE 3rd, Wu Y, Smith K, Charles P, Powers K, Wang H, Patterson C
Molecular and cellular biology27(18)6407-19(2007 Sep)

Structural and functional insights into the B30.2/SPRY domain.
Woo JS, Imm JH, Min CK, Kim KJ, Cha SS, Oh BH
The EMBO journal25(6)1353-63(2006 Mar)

Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase.
Brower CS, Sato S, Tomomori-Sato C, Kamura T, Pause A, Stearman R, Klausner RD, Malik S, Lane WS, Sorokina I, Roeder RG, Conaway JW, Conaway RC
Proceedings of the National Academy of Sciences of the United States of America99(16)10353-8(2002 Aug)

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase.
Kamura T, Koepp DM, Conrad MN, Skowyra D, Moreland RJ, Iliopoulos O, Lane WS, Kaelin WG Jr, Elledge SJ, Conaway RC, Harper JW, Conaway JW
Science (New York, N.Y.)284(5414)657-61(1999 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Tceb2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tceb2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07683	NM_031129.3 Latest version!	Rattus norvegicus elongin B (Elob), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
ORa43741	XM_008767596.1 Latest version!	Rattus norvegicus transcription elongation factor B subunit 2 (Tceb2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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1 Clone	30% OFF
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5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tceb2 ( NM_031129.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112391.1 Rattus norvegicus elongin B (Elob), mRNA.

Price & Availability↑

CloneID	ORa07683
Clone ID Related Accession (Same CDS sequence)	NM_031129.3
Accession Version	NM_031129.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 357bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	elongin-B
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC058463.1. On Aug 31, 2012 this sequence version replaced NM_031129.2. ##Evidence-Data-START## Transcript exon combination :: BC058463.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906347, SAMN01906348 [ECO:0000348] ##Evidence-Data-END##

ATGGACGTGT TTCTCATGAT CCGGCGCCAC AAGACCACCA TCTTTACGGA CGCCAAGGAG 
TCGAGCACGG TGTTCGAACT GAAGCGCATC GTCGAGGGCA TCCTCAAGCG GCCGCCAGAG 
GAGCAGCGGC TGTACAAGGA CGACCAGCTC CTTGATGATG GAAAAACTCT GGGCGAATGT 
GGCTTCACCA GTCAGACAGC AAGGCCACAG GCCCCAGCCA CAGTGGGCCT GGCCTTTCGA 
GCAGATGACA CCTTTGAAGC GCTGCGTATT GAACCCTTCT CCAGCCCTCC GGAGCTTCCA 
GATGTGATGA AGCCACAGGA TTCTGGAGGC AGTGCCAATG AACAAGCTGT GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112391.1
CDS	41..397
Translation	MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPEEQRLYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFRADDTFEALRIEPFSSPPELPDVMKPQDSGGSANEQAVQ

Target ORF information:

RefSeq Version	NM_031129.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus elongin B (Elob), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031129.3

ORF Insert Sequence:

ATGGACGTGT TTCTCATGAT CCGGCGCCAC AAGACCACCA TCTTTACGGA CGCCAAGGAG 
TCGAGCACGG TGTTCGAACT GAAGCGCATC GTCGAGGGCA TCCTCAAGCG GCCGCCAGAG 
GAGCAGCGGC TGTACAAGGA CGACCAGCTC CTTGATGATG GAAAAACTCT GGGCGAATGT 
GGCTTCACCA GTCAGACAGC AAGGCCACAG GCCCCAGCCA CAGTGGGCCT GGCCTTTCGA 
GCAGATGACA CCTTTGAAGC GCTGCGTATT GAACCCTTCT CCAGCCCTCC GGAGCTTCCA 
GATGTGATGA AGCCACAGGA TTCTGGAGGC AGTGCCAATG AACAAGCTGT GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tceb2 ( XM_008767596.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008765818.1 Rattus norvegicus transcription elongation factor B subunit 2 (Tceb2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa43741
Clone ID Related Accession (Same CDS sequence)	XM_008767596.1
Accession Version	XM_008767596.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 342bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	transcription elongation factor B polypeptide 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATCCGGC GCCACAAGAC CACCATCTTT ACGGACGCCA AGGAGTCGAG CACGGTGTTC 
GAACTGAAGC GCATCGTCGA GGGCATCCTC AAGCGGCCGC CAGAGGAGCA GCGGCTGTAC 
AAGGACGACC AGCTCCTTGA TGATGGAAAA ACTCTGGGCG AATGTGGCTT CACCAGTCAG 
ACAGCAAGGC CACAGGCCCC AGCCACAGTG GGCCTGGCCT TTCGAGCAGA TGACACCTTT 
GAAGCGCTGC GTATTGAACC CTTCTCCAGC CCTCCGGAGC TTCCAGATGT GATGAAGCCA 
CAGGATTCTG GAGGCAGTGC CAATGAACAA GCTGTGCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008765818.1
CDS	62..403
Translation	MIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPEEQRLYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFRADDTFEALRIEPFSSPPELPDVMKPQDSGGSANEQAVQ

Target ORF information:

RefSeq Version	XM_008767596.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus transcription elongation factor B subunit 2 (Tceb2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008767596.1

ORF Insert Sequence:

ATGATCCGGC GCCACAAGAC CACCATCTTT ACGGACGCCA AGGAGTCGAG CACGGTGTTC 
GAACTGAAGC GCATCGTCGA GGGCATCCTC AAGCGGCCGC CAGAGGAGCA GCGGCTGTAC 
AAGGACGACC AGCTCCTTGA TGATGGAAAA ACTCTGGGCG AATGTGGCTT CACCAGTCAG 
ACAGCAAGGC CACAGGCCCC AGCCACAGTG GGCCTGGCCT TTCGAGCAGA TGACACCTTT 
GAAGCGCTGC GTATTGAACC CTTCTCCAGC CCTCCGGAGC TTCCAGATGT GATGAAGCCA 
CAGGATTCTG GAGGCAGTGC CAATGAACAA GCTGTGCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Regulation of oxygen homeostasis by hypoxia-inducible factor 1.
Physiology (Bethesda, Md.)2497-106(2009 Apr)
Semenza GL

ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism.
Molecular and cellular biology27(18)6407-19(2007 Sep)
Ferguson JE 3rd,Wu Y,Smith K,Charles P,Powers K,Wang H,Patterson C

Structural and functional insights into the B30.2/SPRY domain.
The EMBO journal25(6)1353-63(2006 Mar)
Woo JS,Imm JH,Min CK,Kim KJ,Cha SS,Oh BH

Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase.
Proceedings of the National Academy of Sciences of the United States of America99(16)10353-8(2002 Aug)
Brower CS,Sato S,Tomomori-Sato C,Kamura T,Pause A,Stearman R,Klausner RD,Malik S,Lane WS,Sorokina I,Roeder RG,Conaway JW,Conaway RC

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase.
Science (New York, N.Y.)284(5414)657-61(1999 Apr)
Kamura T,Koepp DM,Conrad MN,Skowyra D,Moreland RJ,Iliopoulos O,Lane WS,Kaelin WG Jr,Elledge SJ,Conaway RC,Harper JW,Conaway JW

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Tceb2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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