Mdk cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mdk
Entrez Gene ID	81517
Full Name	midkine
General protein information	Preferred Names midkine Names midkine MK
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q24
Summary	heparin-binding growth factor; involved in early fetal development of the rat adrenal [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006234591.3	XP_006234653.1	midkine isoform X1
XM_006234593.3	XP_006234655.1	midkine isoform X2
NM_030859.2	NP_110486.1	midkine precursor
XM_006234592.2	XP_006234654.1	midkine isoform X2

Pathways from BioSystems

Homologies

Homo sapiens (human)	MDK	NP_002382.1
Danio rerio (zebrafish)	mdka	NP_571145.1
Danio rerio (zebrafish)	mdkb	NP_571791.1
Rattus norvegicus (Norway rat)	Mdk	NP_110486.1
	MDK	XP_002799613.1
Mus musculus (house mouse)	Mdk	NP_034914.1
Gallus gallus (chicken)	MDK	NP_001106760.1
Bos taurus (cattle)	MDK	NP_776360.2
Xenopus tropicalis (tropical clawed frog)	mdk	NP_989074.1

Gene Ontology
Bibliography

Related articles in PubMed

Midkine Controls Arteriogenesis by Regulating the Bioavailability of Vascular Endothelial Growth Factor A and the Expression of Nitric Oxide Synthase 1 and 3.
Lautz T, Lasch M, Borgolte J, Troidl K, Pagel JI, Caballero-Martinez A, Kleinert EC, Walzog B, Deindl E
EBioMedicine(2017 Nov)

Effect of retinoic acid on midkine gene expression in rat anterior pituitary cells.
Maliza R, Fujiwara K, Azuma M, Kikuchi M, Yashiro T
Endocrine journal64(6)633-638(2017 Jun)

Growth Factor Midkine Promotes T-Cell Activation through Nuclear Factor of Activated T Cells Signaling and Th1 Cell Differentiation in Lupus Nephritis.
Masuda T, Maeda K, Sato W, Kosugi T, Sato Y, Kojima H, Kato N, Ishimoto T, Tsuboi N, Uchimura K, Yuzawa Y, Maruyama S, Kadomatsu K
The American journal of pathology187(4)740-751(2017 Apr)

Role of Chondroitin Sulfate (CS) Modification in the Regulation of Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity: PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE DIFFERENTIATION.
Kuboyama K, Fujikawa A, Suzuki R, Tanga N, Noda M
The Journal of biological chemistry291(35)18117-28(2016 08)

Midkine-deficiency delays chondrogenesis during the early phase of fracture healing in mice.
Haffner-Luntzer M, Heilmann A, Rapp AE, Beie S, Schinke T, Amling M, Ignatius A, Liedert A
PloS one9(12)e116282(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MK and its receptor, protein tyrosine phosphatase receptor-type Z (Ptprz1), are present in the adult rat pituitary
Title: Expression of the heparin-binding growth factor midkine and its receptor, Ptprz1, in adult rat pituitary.

We hypothesize a role for these cytokines in mediating, at least in part, acute neuroprotective effects and chronic neurotrophic adaptations that contribute to drug dependence.
Title: Glial activation and midkine and pleiotrophin transcription in the ventral tegmental area are modulated by morphine administration.

Downregulation of MK gene on D15 may contribute to primary PH in the nitrofen CDH model by disrupting early lung morphogenesis.
Title: Downregulation of Midkine gene expression and its response to retinoic acid treatment in the nitrofen-induced hypoplastic lung.

The angiogenic factor midkine is regulated by dexamethasone and retinoic acid during alveolarization and in alveolar epithelial cells.
Title: The angiogenic factor midkine is regulated by dexamethasone and retinoic acid during alveolarization and in alveolar epithelial cells.

The apoA-V-midkine binding at the cell surface using antibody directed against midkine is able to influence INS-1 cell function as insulin secretion.
Title: Apolipoprotein A-V modulates insulin secretion in pancreatic beta-cells through its interaction with midkine.

The following Mdk gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mdk cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa07216	NM_030859.2 Latest version!	Rattus norvegicus midkine (Mdk), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa07216	XM_006234592.2 Latest version!	Rattus norvegicus midkine (Mdk), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa07216	XM_006234593.3 Latest version!	Rattus norvegicus midkine (Mdk), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa26122	XM_006234591.3 Latest version!	Rattus norvegicus midkine (Mdk), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mdk ( NM_030859.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_110486.1 Rattus norvegicus midkine (Mdk), mRNA.

Price & Availability↑

CloneID	ORa07216
Clone ID Related Accession (Same CDS sequence)	XM_006234593.3 , NM_030859.2 , XM_006234592.2
Accession Version	NM_030859.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 423bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	midkine precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB025023.1. On Jun 10, 2007 this sequence version replaced NM_030859.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB025023.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906347, SAMN01906348 [ECO:0000348] ##Evidence-Data-END##

ATGCAGCACC GAAGTTTCTT CCTTCTAGCC CTTGTTGCCC TCTTGGCTGT CACGACCGCG 
GTGGCCAAAA AGAAAGACAA GGTGAAGAAG GGCAGCGAGT GTTCGGAGTG GACCTGGGGG 
CCCTGCACCC CCAGCAGCAA GGACTGCGGC ATGGGTTTCC GCGAGGGTAC CTGTGGGGCC 
CAGACCCAGC GCATCCATTG CAAGGTGCCC TGCAACTGGA AGAAGGAGTT TGGAGCCGAC 
TGCAAATACA AGTTTGAGAG CTGGGGGGCG TGTGATGGGA GCACTGGCAC CAAAGCCCGC 
CAAGGGACCC TGAAGAAGGC TCGGTACAAT GCCCAGTGCC AGGAGACCAT CCGCGTGACC 
AAGCCCTGCA CCTCCAAGAC CAAGTCAAAG GCCAAAGCCA AGAAAGGAAA AGGAAAGGAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_110486.1
CDS	1..423
Translation	MQHRSFFLLALVALLAVTTAVAKKKDKVKKGSECSEWTWGPCTPSSKDCGMGFREGTCGAQTQRIHCKVPCNWKKEFGADCKYKFESWGACDGSTGTKARQGTLKKARYNAQCQETIRVTKPCTSKTKSKAKAKKGKGKD

Target ORF information:

RefSeq Version	NM_030859.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus midkine (Mdk), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030859.2

ORF Insert Sequence:

ATGCAGCACC GAAGTTTCTT CCTTCTAGCC CTTGTTGCCC TCTTGGCTGT CACGACCGCG 
GTGGCCAAAA AGAAAGACAA GGTGAAGAAG GGCAGCGAGT GTTCGGAGTG GACCTGGGGG 
CCCTGCACCC CCAGCAGCAA GGACTGCGGC ATGGGTTTCC GCGAGGGTAC CTGTGGGGCC 
CAGACCCAGC GCATCCATTG CAAGGTGCCC TGCAACTGGA AGAAGGAGTT TGGAGCCGAC 
TGCAAATACA AGTTTGAGAG CTGGGGGGCG TGTGATGGGA GCACTGGCAC CAAAGCCCGC 
CAAGGGACCC TGAAGAAGGC TCGGTACAAT GCCCAGTGCC AGGAGACCAT CCGCGTGACC 
AAGCCCTGCA CCTCCAAGAC CAAGTCAAAG GCCAAAGCCA AGAAAGGAAA AGGAAAGGAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mdk ( XM_006234593.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006234655.1 Rattus norvegicus midkine (Mdk), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa07216
Clone ID Related Accession (Same CDS sequence)	XM_006234593.3 , NM_030859.2 , XM_006234592.2
Accession Version	XM_006234593.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 423bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	midkine isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006234593.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGCACC GAAGTTTCTT CCTTCTAGCC CTTGTTGCCC TCTTGGCTGT CACGACCGCG 
GTGGCCAAAA AGAAAGACAA GGTGAAGAAG GGCAGCGAGT GTTCGGAGTG GACCTGGGGG 
CCCTGCACCC CCAGCAGCAA GGACTGCGGC ATGGGTTTCC GCGAGGGTAC CTGTGGGGCC 
CAGACCCAGC GCATCCATTG CAAGGTGCCC TGCAACTGGA AGAAGGAGTT TGGAGCCGAC 
TGCAAATACA AGTTTGAGAG CTGGGGGGCG TGTGATGGGA GCACTGGCAC CAAAGCCCGC 
CAAGGGACCC TGAAGAAGGC TCGGTACAAT GCCCAGTGCC AGGAGACCAT CCGCGTGACC 
AAGCCCTGCA CCTCCAAGAC CAAGTCAAAG GCCAAAGCCA AGAAAGGAAA AGGAAAGGAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006234655.1
CDS	773..1195
Translation	MQHRSFFLLALVALLAVTTAVAKKKDKVKKGSECSEWTWGPCTPSSKDCGMGFREGTCGAQTQRIHCKVPCNWKKEFGADCKYKFESWGACDGSTGTKARQGTLKKARYNAQCQETIRVTKPCTSKTKSKAKAKKGKGKD

Target ORF information:

RefSeq Version	XM_006234593.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus midkine (Mdk), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006234593.3

ORF Insert Sequence:

ATGCAGCACC GAAGTTTCTT CCTTCTAGCC CTTGTTGCCC TCTTGGCTGT CACGACCGCG 
GTGGCCAAAA AGAAAGACAA GGTGAAGAAG GGCAGCGAGT GTTCGGAGTG GACCTGGGGG 
CCCTGCACCC CCAGCAGCAA GGACTGCGGC ATGGGTTTCC GCGAGGGTAC CTGTGGGGCC 
CAGACCCAGC GCATCCATTG CAAGGTGCCC TGCAACTGGA AGAAGGAGTT TGGAGCCGAC 
TGCAAATACA AGTTTGAGAG CTGGGGGGCG TGTGATGGGA GCACTGGCAC CAAAGCCCGC 
CAAGGGACCC TGAAGAAGGC TCGGTACAAT GCCCAGTGCC AGGAGACCAT CCGCGTGACC 
AAGCCCTGCA CCTCCAAGAC CAAGTCAAAG GCCAAAGCCA AGAAAGGAAA AGGAAAGGAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mdk ( XM_006234592.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006234654.1 Rattus norvegicus midkine (Mdk), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa07216
Clone ID Related Accession (Same CDS sequence)	XM_006234593.3 , NM_030859.2 , XM_006234592.2
Accession Version	XM_006234592.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 423bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	midkine isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006234592.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGCACC GAAGTTTCTT CCTTCTAGCC CTTGTTGCCC TCTTGGCTGT CACGACCGCG 
GTGGCCAAAA AGAAAGACAA GGTGAAGAAG GGCAGCGAGT GTTCGGAGTG GACCTGGGGG 
CCCTGCACCC CCAGCAGCAA GGACTGCGGC ATGGGTTTCC GCGAGGGTAC CTGTGGGGCC 
CAGACCCAGC GCATCCATTG CAAGGTGCCC TGCAACTGGA AGAAGGAGTT TGGAGCCGAC 
TGCAAATACA AGTTTGAGAG CTGGGGGGCG TGTGATGGGA GCACTGGCAC CAAAGCCCGC 
CAAGGGACCC TGAAGAAGGC TCGGTACAAT GCCCAGTGCC AGGAGACCAT CCGCGTGACC 
AAGCCCTGCA CCTCCAAGAC CAAGTCAAAG GCCAAAGCCA AGAAAGGAAA AGGAAAGGAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006234654.1
CDS	114..536
Translation	MQHRSFFLLALVALLAVTTAVAKKKDKVKKGSECSEWTWGPCTPSSKDCGMGFREGTCGAQTQRIHCKVPCNWKKEFGADCKYKFESWGACDGSTGTKARQGTLKKARYNAQCQETIRVTKPCTSKTKSKAKAKKGKGKD

Target ORF information:

RefSeq Version	XM_006234592.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus midkine (Mdk), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006234592.2

ORF Insert Sequence:

ATGCAGCACC GAAGTTTCTT CCTTCTAGCC CTTGTTGCCC TCTTGGCTGT CACGACCGCG 
GTGGCCAAAA AGAAAGACAA GGTGAAGAAG GGCAGCGAGT GTTCGGAGTG GACCTGGGGG 
CCCTGCACCC CCAGCAGCAA GGACTGCGGC ATGGGTTTCC GCGAGGGTAC CTGTGGGGCC 
CAGACCCAGC GCATCCATTG CAAGGTGCCC TGCAACTGGA AGAAGGAGTT TGGAGCCGAC 
TGCAAATACA AGTTTGAGAG CTGGGGGGCG TGTGATGGGA GCACTGGCAC CAAAGCCCGC 
CAAGGGACCC TGAAGAAGGC TCGGTACAAT GCCCAGTGCC AGGAGACCAT CCGCGTGACC 
AAGCCCTGCA CCTCCAAGAC CAAGTCAAAG GCCAAAGCCA AGAAAGGAAA AGGAAAGGAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mdk ( XM_006234591.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006234653.1 Rattus norvegicus midkine (Mdk), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa26122
Clone ID Related Accession (Same CDS sequence)	XM_006234591.3
Accession Version	XM_006234591.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	midkine isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006234591.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGGATGC AGCACCGAAG TTTCTTCCTT CTAGCCCTTG TTGCCCTCTT GGCTGTCACG 
ACCGCGGTGG CCAAAAAGAA AGACAAGGTG AAGAAGGGCA GCGAGTGTTC GGAGTGGACC 
TGGGGGCCCT GCACCCCCAG CAGCAAGGAC TGCGGCATGG GTTTCCGCGA GGGTACCTGT 
GGGGCCCAGA CCCAGCGCAT CCATTGCAAG GTGCCCTGCA ACTGGAAGAA GGAGTTTGGA 
GCCGACTGCA AATACAAGTT TGAGAGCTGG GGGGCGTGTG ATGGGAGCAC TGGCACCAAA 
GCCCGCCAAG GGACCCTGAA GAAGGCTCGG TACAATGCCC AGTGCCAGGA GACCATCCGC 
GTGACCAAGC CCTGCACCTC CAAGACCAAG TCAAAGGCCA AAGCCAAGAA AGGAAAAGGA 
AAGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006234653.1
CDS	167..595
Translation	MRMQHRSFFLLALVALLAVTTAVAKKKDKVKKGSECSEWTWGPCTPSSKDCGMGFREGTCGAQTQRIHCKVPCNWKKEFGADCKYKFESWGACDGSTGTKARQGTLKKARYNAQCQETIRVTKPCTSKTKSKAKAKKGKGKD

Target ORF information:

RefSeq Version	XM_006234591.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus midkine (Mdk), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006234591.3

ORF Insert Sequence:

ATGAGGATGC AGCACCGAAG TTTCTTCCTT CTAGCCCTTG TTGCCCTCTT GGCTGTCACG 
ACCGCGGTGG CCAAAAAGAA AGACAAGGTG AAGAAGGGCA GCGAGTGTTC GGAGTGGACC 
TGGGGGCCCT GCACCCCCAG CAGCAAGGAC TGCGGCATGG GTTTCCGCGA GGGTACCTGT 
GGGGCCCAGA CCCAGCGCAT CCATTGCAAG GTGCCCTGCA ACTGGAAGAA GGAGTTTGGA 
GCCGACTGCA AATACAAGTT TGAGAGCTGG GGGGCGTGTG ATGGGAGCAC TGGCACCAAA 
GCCCGCCAAG GGACCCTGAA GAAGGCTCGG TACAATGCCC AGTGCCAGGA GACCATCCGC 
GTGACCAAGC CCTGCACCTC CAAGACCAAG TCAAAGGCCA AAGCCAAGAA AGGAAAAGGA 
AAGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Midkine Controls Arteriogenesis by Regulating the Bioavailability of Vascular Endothelial Growth Factor A and the Expression of Nitric Oxide Synthase 1 and 3.
EBioMedicine(2017 Nov)
Lautz T,Lasch M,Borgolte J,Troidl K,Pagel JI,Caballero-Martinez A,Kleinert EC,Walzog B,Deindl E

Effect of retinoic acid on midkine gene expression in rat anterior pituitary cells.
Endocrine journal64(6)633-638(2017 Jun)
Maliza R,Fujiwara K,Azuma M,Kikuchi M,Yashiro T

Growth Factor Midkine Promotes T-Cell Activation through Nuclear Factor of Activated T Cells Signaling and Th1 Cell Differentiation in Lupus Nephritis.
The American journal of pathology187(4)740-751(2017 Apr)
Masuda T,Maeda K,Sato W,Kosugi T,Sato Y,Kojima H,Kato N,Ishimoto T,Tsuboi N,Uchimura K,Yuzawa Y,Maruyama S,Kadomatsu K

Role of Chondroitin Sulfate (CS) Modification in the Regulation of Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity: PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE DIFFERENTIATION.
The Journal of biological chemistry291(35)18117-28(2016 08)
Kuboyama K,Fujikawa A,Suzuki R,Tanga N,Noda M

Midkine-deficiency delays chondrogenesis during the early phase of fracture healing in mice.
PloS one9(12)e116282(2014)
Haffner-Luntzer M,Heilmann A,Rapp AE,Beie S,Schinke T,Amling M,Ignatius A,Liedert A

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Mdk cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム