Zfp36 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Zfp36
Entrez Gene ID	79426
Full Name	zinc finger protein 36
Synonyms	Tis11
General protein information	Preferred Names zinc finger protein 36 Names mRNA decay activator protein ZFP36 TPA-induced sequence 11 TTP tristetraprolin tristetraproline zfp-36
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q21
Summary	acts as a transcriptional activator [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_133290.3	NP_579824.2	mRNA decay activator protein ZFP36

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	zfp36	NP_001106542.1
	LOC722000	XP_002801521.1
Pan troglodytes (chimpanzee)	ZFP36	XP_001136016.1
Bos taurus (cattle)	ZFP36	NP_776918.1
Rattus norvegicus (Norway rat)	Zfp36	NP_579824.2
Homo sapiens (human)	ZFP36	NP_003398.2
Canis lupus familiaris (dog)	ZFP36	XP_541624.3
Mus musculus (house mouse)	Zfp36	NP_035886.1

Gene Ontology
Bibliography

Related articles in PubMed

Destabilization of the ornithine decarboxylase mRNA transcript by the RNA-binding protein tristetraprolin.
Nowotarski SL, Origanti S, Sass-Kuhn S, Shantz LM
Amino acids48(10)2303-11(2016 Oct)

Functional analysis of ZFP36 proteins in keratinocytes.
Prenzler F, Fragasso A, Schmitt A, Munz B
European journal of cell biology95(8)277-84(2016 Aug)

CNOT7/hCAF1 is involved in ICAM-1 and IL-8 regulation by tristetraprolin.
Shi JX, Li JS, Hu R, Shi Y, Su X, Li Q, Zhang F
Cellular signalling26(11)2390-6(2014 Nov)

Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase.
Tan FE, Elowitz MB
Proceedings of the National Academy of Sciences of the United States of America111(17)E1740-8(2014 Apr)

Transforming growth factor ? regulates P-body formation through induction of the mRNA decay factor tristetraprolin.
Blanco FF, Sanduja S, Deane NG, Blackshear PJ, Dixon DA
Molecular and cellular biology34(2)180-95(2014 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TGF-beta as a novel mRNA stability regulator in intestinal epithelium through its ability to promote TTP expression and subsequent P-body formation.
Title: Transforming growth factor ? regulates P-body formation through induction of the mRNA decay factor tristetraprolin.

These findings indicate a role for TTP in the insulin-mediated activation of hepatic HMGR transcription.
Title: Involvement of tristetraprolin in transcriptional activation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase by insulin.

recruitment of TIS11 to heat shock-induced stress granules is governed by the tandem zinc finger domains of this protein
Title: Recruitment of mRNA-destabilizing protein TIS11 to stress granules is mediated by its zinc finger domain.

Identification of nuclear import and export signals within the structure of the zinc finger protein TIS11
Title: Identification of nuclear import and export signals within the structure of the zinc finger protein TIS11.

The following Zfp36 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Zfp36 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12083	NM_133290.3 Latest version!	Rattus norvegicus zinc finger protein 36 (Zfp36), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Zfp36 ( NM_133290.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_579824.2 Rattus norvegicus zinc finger protein 36 (Zfp36), mRNA.

Price & Availability↑

CloneID	ORa12083
Clone ID Related Accession (Same CDS sequence)	NM_133290.3
Accession Version	NM_133290.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 981bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	mRNA decay activator protein ZFP36
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC060308.1 and BP474238.1. On May 26, 2007 this sequence version replaced NM_133290.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC060308.1, DN947963.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCCATTC GCGCCACCAT GGATCTCTCT GCCATCTACG AGAGCCTTAT GTCGATGAGC 
CATGACCTGT CACCCGACCA CGGAGGAACT GAGTCCTCCG GAGGACTTTG GAACATAAAC 
TCATCGGACT CCATCCCATC TGGGGTCACC TCTCGCCTGA CTGGCCGCTC CACTAGCCTG 
GTGGAGGGCC GAAGCTGCAG CTGGGTACCC CCACCCCCTG GTTTCGCACC CTTGGCTCCC 
CGCCCGGGCC CTGAGCTGTC ACCCTCACCT ACTTCGCCTA CTGCAACTCC CACCACCTCC 
TCTCGATACA AGACTGAGCT CTGTCGGACC TACTCAGAGA GCGGGCGTTG TCGCTATGGG 
GCCAAGTGCC AGTTTGCCCA CGGCCCGGGT GAACTGCGCC AAGCCAATCG CCACCCCAAG 
TACAAAACGG AACTCTGCCA CAAGTTCTAC CTCCAGGGCC GCTGCCCCTA CGGCTCTCGA 
TGCCACTTCA TCCACAACCC TACCGAGGAC CTGGCTCTCC CTGGCCAGCC CCATGTGCTC 
CGACAAAGCA TCAGCTTCTC AGGCTTGCCT TCAGGCCGCA GAACCTCACC ACCACCTCCA 
GGCTTCTCTG GCCCTTCCCT GTCCTCTTGC TCCTTTTCGC CTTCCAGCTC CCCACCACCG 
CCTGGGGACC TTCCACTTTC CCCTTCTGCC TTCTCTGCTG CCCCTGGGAC CCCTGTGTCT 
CGAAGAGACC CTACCCCAGC CTGTTGTCCC TCCTGCCGAA GGTCTACTAC CCCTAGCACC 
ATCTGGGGGC CCTTGGGTGG TCTGGCTCGG AGCCCATCTG CACACTCTCT GGGATCCGAC 
CCTGATGATT ACGCCAGCAG CGGCAGCAGC CTGGGTGGGT CAGACTCGCC TGTCTTTGAG 
GCCGGGGTGT TTGGGCCTCC TCAGCCCCCT GCACCCCCAA GGCGTCTTCC CATCTTCAAT 
CGCATCTCTG TCTCTGAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_579824.2
CDS	41..1021
Translation	MAIRATMDLSAIYESLMSMSHDLSPDHGGTESSGGLWNINSSDSIPSGVTSRLTGRSTSLVEGRSCSWVPPPPGFAPLAPRPGPELSPSPTSPTATPTTSSRYKTELCRTYSESGRCRYGAKCQFAHGPGELRQANRHPKYKTELCHKFYLQGRCPYGSRCHFIHNPTEDLALPGQPHVLRQSISFSGLPSGRRTSPPPPGFSGPSLSSCSFSPSSSPPPPGDLPLSPSAFSAAPGTPVSRRDPTPACCPSCRRSTTPSTIWGPLGGLARSPSAHSLGSDPDDYASSGSSLGGSDSPVFEAGVFGPPQPPAPPRRLPIFNRISVSE

Target ORF information:

RefSeq Version	NM_133290.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus zinc finger protein 36 (Zfp36), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133290.3

ORF Insert Sequence:

ATGGCCATTC GCGCCACCAT GGATCTCTCT GCCATCTACG AGAGCCTTAT GTCGATGAGC 
CATGACCTGT CACCCGACCA CGGAGGAACT GAGTCCTCCG GAGGACTTTG GAACATAAAC 
TCATCGGACT CCATCCCATC TGGGGTCACC TCTCGCCTGA CTGGCCGCTC CACTAGCCTG 
GTGGAGGGCC GAAGCTGCAG CTGGGTACCC CCACCCCCTG GTTTCGCACC CTTGGCTCCC 
CGCCCGGGCC CTGAGCTGTC ACCCTCACCT ACTTCGCCTA CTGCAACTCC CACCACCTCC 
TCTCGATACA AGACTGAGCT CTGTCGGACC TACTCAGAGA GCGGGCGTTG TCGCTATGGG 
GCCAAGTGCC AGTTTGCCCA CGGCCCGGGT GAACTGCGCC AAGCCAATCG CCACCCCAAG 
TACAAAACGG AACTCTGCCA CAAGTTCTAC CTCCAGGGCC GCTGCCCCTA CGGCTCTCGA 
TGCCACTTCA TCCACAACCC TACCGAGGAC CTGGCTCTCC CTGGCCAGCC CCATGTGCTC 
CGACAAAGCA TCAGCTTCTC AGGCTTGCCT TCAGGCCGCA GAACCTCACC ACCACCTCCA 
GGCTTCTCTG GCCCTTCCCT GTCCTCTTGC TCCTTTTCGC CTTCCAGCTC CCCACCACCG 
CCTGGGGACC TTCCACTTTC CCCTTCTGCC TTCTCTGCTG CCCCTGGGAC CCCTGTGTCT 
CGAAGAGACC CTACCCCAGC CTGTTGTCCC TCCTGCCGAA GGTCTACTAC CCCTAGCACC 
ATCTGGGGGC CCTTGGGTGG TCTGGCTCGG AGCCCATCTG CACACTCTCT GGGATCCGAC 
CCTGATGATT ACGCCAGCAG CGGCAGCAGC CTGGGTGGGT CAGACTCGCC TGTCTTTGAG 
GCCGGGGTGT TTGGGCCTCC TCAGCCCCCT GCACCCCCAA GGCGTCTTCC CATCTTCAAT 
CGCATCTCTG TCTCTGAGTG A