Gdf10 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gdf10
Entrez Gene ID	79216
Full Name	growth differentiation factor 10
General protein information	Preferred Names growth differentiation factor 10 Names growth/differentiation factor 10 BIP BMP-3b GDF-10 bone morphogenetic protein 3b bone-inducing protein prepro bone inducing protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16p16
Summary	may play a role in the central nervous system, in bone formation and remodeling [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_024375.1	NP_077351.1	growth/differentiation factor 10 precursor

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	gdf10a	XP_691459.3
Mus musculus (house mouse)	Gdf10	NP_665684.2
Pan troglodytes (chimpanzee)	GDF10	XP_001135281.2
Rattus norvegicus (Norway rat)	Gdf10	NP_077351.1
Homo sapiens (human)	GDF10	NP_004953.1
	GDF10	XP_001109475.1
Canis lupus familiaris (dog)	GDF10	XP_853904.2
Bos taurus (cattle)	GDF10	NP_001069635.1
Gallus gallus (chicken)	GDF10	XP_421648.3
Xenopus tropicalis (tropical clawed frog)	gdf10	XP_004915891.1

Gene Ontology
Bibliography

Related articles in PubMed

Decrease of growth and differentiation factor 10 contributes to neuropathic pain through N-methyl-D-aspartate receptor activation.
Jiang L, Tan B, Li S, Wang L, Zheng L, Liu Y, Long Z, Wu Y
Neuroreport28(8)444-450(2017 May)

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Barallobre-Barreiro J, Oklu R, Lynch M, Fava M, Baig F, Yin X, Barwari T, Potier DN, Albadawi H, Jahangiri M, Porter KE, Watkins MT, Misra S, Stoughton J, Mayr M
Cardiovascular research110(3)419-30(2016 06)

The nuclear receptor REV-ERB? represses the transcription of growth/differentiation factor 10 and 15 genes in rat endometrium stromal cells.
Zhao L, Isayama K, Chen H, Yamauchi N, Shigeyoshi Y, Hashimoto S, Hattori MA
Physiological reports4(2)(2016 Feb)

Bone morphogenetic protein-3b (BMP-3b) is expressed in adipocytes and inhibits adipogenesis as a unique complex.
Hino J, Miyazawa T, Miyazato M, Kangawa K
International journal of obesity (2005)36(5)725-34(2012 May)

Spatial and temporal regulation of gene expression in the mammalian growth plate.
Lui JC, Andrade AC, Forcinito P, Hegde A, Chen W, Baron J, Nilsson O
Bone46(5)1380-90(2010 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

findings indicate that the attenuation of REV-ERBalpha leads to an upregulation of Gdf10 and Gdf15 in decidual cells
Title: The nuclear receptor REV-ERB? represses the transcription of growth/differentiation factor 10 and 15 genes in rat endometrium stromal cells.

Gdf10 were present exclusively in the proliferative zone of in growth plate cartilage of 1-week-old rats.
Title: Spatial and temporal regulation of gene expression in the mammalian growth plate.

The following Gdf10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gdf10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06976	NM_024375.1 Latest version!	Rattus norvegicus growth differentiation factor 10 (Gdf10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gdf10 ( NM_024375.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_077351.1 Rattus norvegicus growth differentiation factor 10 (Gdf10), mRNA.

Price & Availability↑

CloneID	ORa06976
Clone ID Related Accession (Same CDS sequence)	NM_024375.1
Accession Version	NM_024375.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1431bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	growth/differentiation factor 10 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D49494.1. On Dec 17, 2003 this sequence version replaced XM_346483.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D49494.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCTCCAG GTCTTGCTCG GATCAGCTTG AGGTCTCAGC TGCTGCCCTT GGTGCCGCTG 
CTCCTGCTAC TGCGGGGCGC AGGCTGCGGC CACAGAGTCC CCTCATGGTC CTCACTGCCT 
TCAGCAGCTG ACAGTGTGCA GAGGGACAGG GACCTCCAGC AGTCACCCGG GGACGCTGCA 
GCCGCTCTGG GTCCAGGCGC CCAGGACATA GTCGCTGTCC ACATGCTCAG GCTCTATGAG 
AAGTACAACC GGAGAGGCGC TCCACCAGGA GGAGGCAACA CCGTCCGAAG CTTCCGTGCC 
CGGCTGGATG TGATCGACCA GAAGCCTGTG TATTTCTTCA ACTTGACTTC CATGCAAGAC 
TCAGAAATGA TCCTCACAGC CACCTTCCAC TTCTACTCAG AACCTCCACG GTGGCCCCGG 
GCTCGTGAGG TATTCTGCAA GCCCCGAGCT AAGAATGCAT CCTGCCGGCT CCTGACCCCA 
GGTCTGCCTG CTCGCTTGCA CCTAATCTTC CGCAGTCTCT CGCAGAACAC TGCCACTCAG 
GGGCTGCTCC GCGGGGCCAT GGCCCTGACA CCTCCACCAC GTGGCCTCTG GCAGGCCAAG 
GACATCTCCT CAATCATCAA GGCTGCCCGA AGGGATGGAG AACTTCTTCT CTCTGCTCAG 
CTGGATTCTG GAGAGAAGGA TCTCGGAGTG CCACGGCCCA GTTCCCACAT GCCCTATATC 
CTTGTCTATG CAAATGACCT GGCCATCTCG GAGCCCAACA GTGTAGCAGT GACGCTACAG 
AGATACGACC CATTTCCAGC TGGAGACTTT GAGCCTGGAG CAGCCCCCAA CAGCTCAGCG 
GATCCCCGCG TGCGCAGGGC GGCACAGGTA TCCAAACCCC TGCAAGACAA TGAACTTCCA 
GGGCTGGACG AAAGACCAGC GCCTGCCCTG CACGCCCAGC ATTTCCACAA GCACGAGTTC 
TGGTCCAGTC CTTTCCGGGC ACTGAAACCC CGCACCGGGC GCAAAGACCG CAAGAAGAAA 
GACCAGGATA CATTCACCCC CTCCTCCTCG CAGGTGCTGG ACTTTGATGA GAAGACGATG 
CAGAAAGCCA GGAGGCGGCA GTGGGATGAG CCTCGGGTCT GCTCCAGGAG GTACCTGAAG 
GTGGATTTTG CAGACATCGG GTGGAATGAA TGGATCATCT CACCCAAATC CTTTGATGCC 
TACTACTGTG CTGGAGCCTG CGAGTTCCCC ATGCCCAAGA TCGTCCGCCC GTCCAACCAT 
GCCACCATCC AGAGCATCGT CAGAGCTGTG GGCATTGTCC CTGGCATCCC GGAGCCATGC 
TGTGTCCCAG ACAAGATGAA CTCCCTTGGA GTCCTTTTCC TGGACGAGAA TCGGAATGTG 
GTTCTGAAGG TGTACCCCAA TATGTCCGTA GAGACCTGTG CCTGTCGGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077351.1
CDS	240..1670
Translation	MAPGLARISLRSQLLPLVPLLLLLRGAGCGHRVPSWSSLPSAADSVQRDRDLQQSPGDAAAALGPGAQDIVAVHMLRLYEKYNRRGAPPGGGNTVRSFRARLDVIDQKPVYFFNLTSMQDSEMILTATFHFYSEPPRWPRAREVFCKPRAKNASCRLLTPGLPARLHLIFRSLSQNTATQGLLRGAMALTPPPRGLWQAKDISSIIKAARRDGELLLSAQLDSGEKDLGVPRPSSHMPYILVYANDLAISEPNSVAVTLQRYDPFPAGDFEPGAAPNSSADPRVRRAAQVSKPLQDNELPGLDERPAPALHAQHFHKHEFWSSPFRALKPRTGRKDRKKKDQDTFTPSSSQVLDFDEKTMQKARRRQWDEPRVCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGIVPGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVETCACR

Target ORF information:

RefSeq Version	NM_024375.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus growth differentiation factor 10 (Gdf10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024375.1

ORF Insert Sequence:

ATGGCTCCAG GTCTTGCTCG GATCAGCTTG AGGTCTCAGC TGCTGCCCTT GGTGCCGCTG 
CTCCTGCTAC TGCGGGGCGC AGGCTGCGGC CACAGAGTCC CCTCATGGTC CTCACTGCCT 
TCAGCAGCTG ACAGTGTGCA GAGGGACAGG GACCTCCAGC AGTCACCCGG GGACGCTGCA 
GCCGCTCTGG GTCCAGGCGC CCAGGACATA GTCGCTGTCC ACATGCTCAG GCTCTATGAG 
AAGTACAACC GGAGAGGCGC TCCACCAGGA GGAGGCAACA CCGTCCGAAG CTTCCGTGCC 
CGGCTGGATG TGATCGACCA GAAGCCTGTG TATTTCTTCA ACTTGACTTC CATGCAAGAC 
TCAGAAATGA TCCTCACAGC CACCTTCCAC TTCTACTCAG AACCTCCACG GTGGCCCCGG 
GCTCGTGAGG TATTCTGCAA GCCCCGAGCT AAGAATGCAT CCTGCCGGCT CCTGACCCCA 
GGTCTGCCTG CTCGCTTGCA CCTAATCTTC CGCAGTCTCT CGCAGAACAC TGCCACTCAG 
GGGCTGCTCC GCGGGGCCAT GGCCCTGACA CCTCCACCAC GTGGCCTCTG GCAGGCCAAG 
GACATCTCCT CAATCATCAA GGCTGCCCGA AGGGATGGAG AACTTCTTCT CTCTGCTCAG 
CTGGATTCTG GAGAGAAGGA TCTCGGAGTG CCACGGCCCA GTTCCCACAT GCCCTATATC 
CTTGTCTATG CAAATGACCT GGCCATCTCG GAGCCCAACA GTGTAGCAGT GACGCTACAG 
AGATACGACC CATTTCCAGC TGGAGACTTT GAGCCTGGAG CAGCCCCCAA CAGCTCAGCG 
GATCCCCGCG TGCGCAGGGC GGCACAGGTA TCCAAACCCC TGCAAGACAA TGAACTTCCA 
GGGCTGGACG AAAGACCAGC GCCTGCCCTG CACGCCCAGC ATTTCCACAA GCACGAGTTC 
TGGTCCAGTC CTTTCCGGGC ACTGAAACCC CGCACCGGGC GCAAAGACCG CAAGAAGAAA 
GACCAGGATA CATTCACCCC CTCCTCCTCG CAGGTGCTGG ACTTTGATGA GAAGACGATG 
CAGAAAGCCA GGAGGCGGCA GTGGGATGAG CCTCGGGTCT GCTCCAGGAG GTACCTGAAG 
GTGGATTTTG CAGACATCGG GTGGAATGAA TGGATCATCT CACCCAAATC CTTTGATGCC 
TACTACTGTG CTGGAGCCTG CGAGTTCCCC ATGCCCAAGA TCGTCCGCCC GTCCAACCAT 
GCCACCATCC AGAGCATCGT CAGAGCTGTG GGCATTGTCC CTGGCATCCC GGAGCCATGC 
TGTGTCCCAG ACAAGATGAA CTCCCTTGGA GTCCTTTTCC TGGACGAGAA TCGGAATGTG 
GTTCTGAAGG TGTACCCCAA TATGTCCGTA GAGACCTGTG CCTGTCGGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Decrease of growth and differentiation factor 10 contributes to neuropathic pain through N-methyl-D-aspartate receptor activation.
Neuroreport28(8)444-450(2017 May)
Jiang L,Tan B,Li S,Wang L,Zheng L,Liu Y,Long Z,Wu Y

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Cardiovascular research110(3)419-30(2016 06)
Barallobre-Barreiro J,Oklu R,Lynch M,Fava M,Baig F,Yin X,Barwari T,Potier DN,Albadawi H,Jahangiri M,Porter KE,Watkins MT,Misra S,Stoughton J,Mayr M

The nuclear receptor REV-ERB? represses the transcription of growth/differentiation factor 10 and 15 genes in rat endometrium stromal cells.
Physiological reports4(2)(2016 Feb)
Zhao L,Isayama K,Chen H,Yamauchi N,Shigeyoshi Y,Hashimoto S,Hattori MA

Bone morphogenetic protein-3b (BMP-3b) is expressed in adipocytes and inhibits adipogenesis as a unique complex.
International journal of obesity (2005)36(5)725-34(2012 May)
Hino J,Miyazawa T,Miyazato M,Kangawa K

Spatial and temporal regulation of gene expression in the mammalian growth plate.
Bone46(5)1380-90(2010 May)
Lui JC,Andrade AC,Forcinito P,Hegde A,Chen W,Baron J,Nilsson O