Sgcb cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sgcb
Entrez Gene ID	680229
Full Name	sarcoglycan, beta
General protein information	Preferred Names sarcoglycan, beta Names beta-sarcoglycan sarcoglycan, beta (dystrophin-associated glycoprotein)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 14 Map Location: 14p11

mRNA and Protein(s)

mRNA	Protein	Name
NM_001191068.1	NP_001177997.1	beta-sarcoglycan

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Sgcb	NP_001177997.1
Gallus gallus (chicken)	SGCB	NP_001026326.1
Homo sapiens (human)	SGCB	NP_000223.1
Pan troglodytes (chimpanzee)	SGCB	XP_517299.2
Canis lupus familiaris (dog)	SGCB	XP_853790.1
Xenopus tropicalis (tropical clawed frog)	sgcb	NP_001135484.1
Bos taurus (cattle)	SGCB	NP_001095658.1
Danio rerio (zebrafish)	sgcb	NP_001030145.1
	SGCB	XP_001090970.1
Mus musculus (house mouse)	Sgcb	NP_036020.1

Gene Ontology
Bibliography

Related articles in PubMed

Systemic AAV-Mediated ?-Sarcoglycan Delivery Targeting Cardiac and Skeletal Muscle Ameliorates Histological and Functional Deficits in LGMD2E Mice.
Pozsgai ER, Griffin DA, Heller KN, Mendell JR, Rodino-Klapac LR
Molecular therapy : the journal of the American Society of Gene Therapy25(4)855-869(2017 Apr)

Preliminary study on sarcoglycan sub-complex in rat cerebral and cerebellar cortex.
Vermiglio G, Runci M, Scibilia A, Biasini F, Cutroneo G
Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia117(1)54-64(2012)

Expression of the dystrophin-glycoprotein complex is a marker for human airway smooth muscle phenotype maturation.
Sharma P, Tran T, Stelmack GL, McNeill K, Gosens R, Mutawe MM, Unruh H, Gerthoffer WT, Halayko AJ
American journal of physiology. Lung cellular and molecular physiology294(1)L57-68(2008 Jan)

Nuclear sequestration of delta-sarcoglycan disrupts the nuclear localization of lamin A/C and emerin in cardiomyocytes.
Heydemann A, Demonbreun A, Hadhazy M, Earley JU, McNally EM
Human molecular genetics16(4)355-63(2007 Feb)

Identification of functional domains in sarcoglycans essential for their interaction and plasma membrane targeting.
Chen J, Shi W, Zhang Y, Sokol R, Cai H, Lun M, Moore BF, Farber MJ, Stepanchick JS, B?nnemann CG, Chan YM
Experimental cell research312(9)1610-25(2006 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In cerebellar neurons and glial cells alpha-, beta-, gamma-, delta-, and epsilon-sarcoglycans are all expressed.
Title: Preliminary study on sarcoglycan sub-complex in rat cerebral and cerebellar cortex.

The following Sgcb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sgcb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06810	NM_001191068.1 Latest version!	Rattus norvegicus sarcoglycan, beta (Sgcb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sgcb ( NM_001191068.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001177997.1 Rattus norvegicus sarcoglycan, beta (Sgcb), mRNA.

Price & Availability↑

CloneID	ORa06810
Clone ID Related Accession (Same CDS sequence)	NM_001191068.1
Accession Version	NM_001191068.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 963bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	beta-sarcoglycan
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AABR07014898.1 and AABR07014899.1. On Jul 17, 2010 this sequence version replaced XM_001056227.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: FQ237016.1, FQ125876.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGCAG CGGCAGCAGC GGCGGCGGCG ACCGAGCAGC AAGGTTCCAA CGGGCCAGTG 
AAGAAGTCCA TGCGGGAGAA GGCAGTGGAA CGAAGGAACG TCAACAAAGA GCATAACAGC 
AACTTCAAAG CTGGGTACAT TCCCATCGAT GAAGACCGGC TGCATAAAAC CGGGCTGAGA 
GGGAGAAAGG GCAACCTAGC CATCTGTGTG ATTGTCCTCC TGTTTATCCT GGCTGTCATC 
AACCTGCTTA TTACACTTGT CATCTGGGCC GTGATTCGCA TTGGGCCAAA TGGCTGTGAC 
AGCTTGGAGT TTCATGAGAG CGGTCTGCTG CGATTCAAGC AAGTGTCCGA CATGGGTATC 
ATCCATCCGC TTTATAAGAG CACAGTGGGA GGAAGGCGGA ATGAAAACCT GGTCATCACT 
GGCAACAACC AGCCGATTGT TTTTCAGCAA GGGACAACCA AGCTGAGTGT TGAAAAGAAC 
AAAACCTCCA TCACCAGCGA CATTGGAATG CAATTTTTTG ACCCAAGGAC ACAAAATATC 
TTATTCAGCA CAGACTATGA GACTCATGAG TTTCACCTGC CAAGCGGAGT GAAAAGTTTG 
AACGTTCAGA AAGCGTCAAC TGAAAGGATC ACCAGCAACG CTACCAGTGA CTTGAACATC 
AAAGTCGATG GGCGTGCAAT TGTGCGAGGC AATGAAGGCG TGTTCATCAT GGGCAAAACC 
ATTGAATTTC ACATGCGAGG GGATGTGGAA CTAAAGGCTG AAAACAGCAT CATCCTCAAT 
GGCACTGTGA TGGTCAGCCC AACGCGTCTG CCCAGCTCCT CCGGCGGAGA CCAGTCAGGC 
AGTGGTGACT GGGTGCGGTA CAAGCTCTGC ATGTGTGCAG ACGGCACACT CTTCAAAGTA 
CAAGTAACAA GCCACAACAT GGGCTGCCAG GTCTCTGACA ACCCTTGTGG AAACACGCAT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001177997.1
CDS	17..979
Translation	MAAAAAAAAATEQQGSNGPVKKSMREKAVERRNVNKEHNSNFKAGYIPIDEDRLHKTGLRGRKGNLAICVIVLLFILAVINLLITLVIWAVIRIGPNGCDSLEFHESGLLRFKQVSDMGIIHPLYKSTVGGRRNENLVITGNNQPIVFQQGTTKLSVEKNKTSITSDIGMQFFDPRTQNILFSTDYETHEFHLPSGVKSLNVQKASTERITSNATSDLNIKVDGRAIVRGNEGVFIMGKTIEFHMRGDVELKAENSIILNGTVMVSPTRLPSSSGGDQSGSGDWVRYKLCMCADGTLFKVQVTSHNMGCQVSDNPCGNTH

Target ORF information:

RefSeq Version	NM_001191068.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus sarcoglycan, beta (Sgcb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001191068.1

ORF Insert Sequence:

ATGGCGGCAG CGGCAGCAGC GGCGGCGGCG ACCGAGCAGC AAGGTTCCAA CGGGCCAGTG 
AAGAAGTCCA TGCGGGAGAA GGCAGTGGAA CGAAGGAACG TCAACAAAGA GCATAACAGC 
AACTTCAAAG CTGGGTACAT TCCCATCGAT GAAGACCGGC TGCATAAAAC CGGGCTGAGA 
GGGAGAAAGG GCAACCTAGC CATCTGTGTG ATTGTCCTCC TGTTTATCCT GGCTGTCATC 
AACCTGCTTA TTACACTTGT CATCTGGGCC GTGATTCGCA TTGGGCCAAA TGGCTGTGAC 
AGCTTGGAGT TTCATGAGAG CGGTCTGCTG CGATTCAAGC AAGTGTCCGA CATGGGTATC 
ATCCATCCGC TTTATAAGAG CACAGTGGGA GGAAGGCGGA ATGAAAACCT GGTCATCACT 
GGCAACAACC AGCCGATTGT TTTTCAGCAA GGGACAACCA AGCTGAGTGT TGAAAAGAAC 
AAAACCTCCA TCACCAGCGA CATTGGAATG CAATTTTTTG ACCCAAGGAC ACAAAATATC 
TTATTCAGCA CAGACTATGA GACTCATGAG TTTCACCTGC CAAGCGGAGT GAAAAGTTTG 
AACGTTCAGA AAGCGTCAAC TGAAAGGATC ACCAGCAACG CTACCAGTGA CTTGAACATC 
AAAGTCGATG GGCGTGCAAT TGTGCGAGGC AATGAAGGCG TGTTCATCAT GGGCAAAACC 
ATTGAATTTC ACATGCGAGG GGATGTGGAA CTAAAGGCTG AAAACAGCAT CATCCTCAAT 
GGCACTGTGA TGGTCAGCCC AACGCGTCTG CCCAGCTCCT CCGGCGGAGA CCAGTCAGGC 
AGTGGTGACT GGGTGCGGTA CAAGCTCTGC ATGTGTGCAG ACGGCACACT CTTCAAAGTA 
CAAGTAACAA GCCACAACAT GGGCTGCCAG GTCTCTGACA ACCCTTGTGG AAACACGCAT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Systemic AAV-Mediated ?-Sarcoglycan Delivery Targeting Cardiac and Skeletal Muscle Ameliorates Histological and Functional Deficits in LGMD2E Mice.
Molecular therapy : the journal of the American Society of Gene Therapy25(4)855-869(2017 Apr)
Pozsgai ER,Griffin DA,Heller KN,Mendell JR,Rodino-Klapac LR

Preliminary study on sarcoglycan sub-complex in rat cerebral and cerebellar cortex.
Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia117(1)54-64(2012)
Vermiglio G,Runci M,Scibilia A,Biasini F,Cutroneo G

Expression of the dystrophin-glycoprotein complex is a marker for human airway smooth muscle phenotype maturation.
American journal of physiology. Lung cellular and molecular physiology294(1)L57-68(2008 Jan)
Sharma P,Tran T,Stelmack GL,McNeill K,Gosens R,Mutawe MM,Unruh H,Gerthoffer WT,Halayko AJ

Nuclear sequestration of delta-sarcoglycan disrupts the nuclear localization of lamin A/C and emerin in cardiomyocytes.
Human molecular genetics16(4)355-63(2007 Feb)
Heydemann A,Demonbreun A,Hadhazy M,Earley JU,McNally EM

Identification of functional domains in sarcoglycans essential for their interaction and plasma membrane targeting.
Experimental cell research312(9)1610-25(2006 May)
Chen J,Shi W,Zhang Y,Sokol R,Cai H,Lun M,Moore BF,Farber MJ,Stepanchick JS,B?nnemann CG,Chan YM