Bid cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Bid
Entrez Gene ID	64625
Full Name	BH3 interacting domain death agonist
General protein information	Preferred Names BH3 interacting domain death agonist Names BH3-interacting domain death agonist apoptotic death agonist BID desmocollin type 4 p22 BID
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q42
Summary	involved in inducing Bax oligomerization in isolated mitochondrial outer membranes [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_022684.1	NP_073175.1	BH3-interacting domain death agonist
XM_017592880.1	XP_017448369.1	BH3-interacting domain death agonist isoform X1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	BID	NP_001068914.1
Pan troglodytes (chimpanzee)	BID	XP_001163696.1
	LOC100426724	XP_002798326.1
Canis lupus familiaris (dog)	BID	NP_001238867.1
Rattus norvegicus (Norway rat)	Bid	NP_073175.1
Homo sapiens (human)	BID	NP_932070.1
Mus musculus (house mouse)	Bid	NP_031570.2
Gallus gallus (chicken)	BID	NP_989883.2

Gene Ontology
Bibliography

Related articles in PubMed

Nuclear translocation of annexin 1 following oxygen-glucose deprivation-reperfusion induces apoptosis by regulating Bid expression via p53 binding.
Li X, Zhao Y, Xia Q, Zheng L, Liu L, Zhao B, Shi J
Cell death & disease7(9)e2356(2016 Sep)

Neonatal bronchopulmonary dysplasia increases neuronal apoptosis in the hippocampus through the HIF-1? and p53 pathways.
Yin R, Yuan L, Ping L, Hu L
Respiratory physiology & neurobiology22081-7(2016 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ANXA1 interacts with p53 and promotes p53 transcriptional activity, which in turn regulates Bid expression.
Title: Nuclear translocation of annexin 1 following oxygen-glucose deprivation-reperfusion induces apoptosis by regulating Bid expression via p53 binding.

disruption of the CHOP/BH3 gene expression homeostasis is detrimental to cell survival independent of other cellular stress.
Title: Hepatocyte autophagy is linked to C/EBP-homologous protein, Bcl2-interacting mediator of cell death, and BH3-interacting domain death agonist gene expression.

By blocking he tBid-mitochondrial apoptotic signaling pathway, neuroprotection against cerebral ischemia is activated.
Title: Inhibition of cysteine cathepsin B and L activation in astrocytes contributes to neuroprotection against cerebral ischemia via blocking the tBid-mitochondrial apoptotic signaling pathway.

act in synergy with Bax in T11TS-mediated glioma apoptosis
Title: Bax and Bid act in synergy to bring about T11TS-mediated glioma apoptosis via the release of mitochondrial cytochrome c and subsequent caspase activation.

tBid has a monofunctional action at low concentrations and basal cytochrome c diffusibility in the intermembrane spaces is adequate for rapid and complete cytochrome c release irrespective of outer membrane permeabilisation.
Title: Evaluating cytochrome c diffusion in the intermembrane spaces of mitochondria during cytochrome c release.

The following Bid gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bid cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06248	NM_022684.1 Latest version!	Rattus norvegicus BH3 interacting domain death agonist (Bid), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa61005	XM_017592880.1 Latest version!	Rattus norvegicus BH3 interacting domain death agonist (Bid), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Bid ( NM_022684.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_073175.1 Rattus norvegicus BH3 interacting domain death agonist (Bid), mRNA.

Price & Availability↑

CloneID	ORa06248
Clone ID Related Accession (Same CDS sequence)	NM_022684.1
Accession Version	NM_022684.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 591bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	BH3-interacting domain death agonist
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF259503.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF259503.1, D89804.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGACTCTG AGGTCAGCAA TGGCTCAGGC CTGGGGGCCG AGCACATCAC AAACCTGCTG 
GTGTTCGGCT TTCTCCGAAA CAATGACCGT GATTTCCACC AAGAGCTGGA GGTACTGGGG 
CAGGAGCTGC CCGTGCAGGT TTACCTGGAG GGGGACCGTG AAGACGAGCT GCAGACAGAT 
GGCAGCCGGG CTAGCCGCTC CTTCTATCAT GGAAGAATAG AGCCAGATTC TGAAAGTCAG 
GATGAAGTCA TCCACAACAT TGCCAGGCAT CTCGCCCAAG CAGGTGATGA ACTGGACCAC 
AGCATCCAGC CCACACTGGT GAGACAACTG GCCGCACAGT TCATGAACGG CAGCCTCTCG 
GAGGAAGACA AAAGGAACTG CCTGGCCAAA GCCCTCGACG AGGTGAAGAC ATCCTTCCCT 
AGGGACATGG AGAACGACAA GGCCATGCTG ATAATGACCA TGCTGTTGGC CAAAAAAGTG 
GCCAGTCATG CACCATCTCT GCTCCGTGAC GTCTTCCGCA CGACCGTGAA CTTTATTAAC 
CAGAACCTAT TCTCCTACGT GAGGGACTTG GTTAGAAATG AGATGGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_073175.1
CDS	143..733
Translation	MDSEVSNGSGLGAEHITNLLVFGFLRNNDRDFHQELEVLGQELPVQVYLEGDREDELQTDGSRASRSFYHGRIEPDSESQDEVIHNIARHLAQAGDELDHSIQPTLVRQLAAQFMNGSLSEEDKRNCLAKALDEVKTSFPRDMENDKAMLIMTMLLAKKVASHAPSLLRDVFRTTVNFINQNLFSYVRDLVRNEMD

Target ORF information:

RefSeq Version	NM_022684.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus BH3 interacting domain death agonist (Bid), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022684.1

ORF Insert Sequence:

ATGGACTCTG AGGTCAGCAA TGGCTCAGGC CTGGGGGCCG AGCACATCAC AAACCTGCTG 
GTGTTCGGCT TTCTCCGAAA CAATGACCGT GATTTCCACC AAGAGCTGGA GGTACTGGGG 
CAGGAGCTGC CCGTGCAGGT TTACCTGGAG GGGGACCGTG AAGACGAGCT GCAGACAGAT 
GGCAGCCGGG CTAGCCGCTC CTTCTATCAT GGAAGAATAG AGCCAGATTC TGAAAGTCAG 
GATGAAGTCA TCCACAACAT TGCCAGGCAT CTCGCCCAAG CAGGTGATGA ACTGGACCAC 
AGCATCCAGC CCACACTGGT GAGACAACTG GCCGCACAGT TCATGAACGG CAGCCTCTCG 
GAGGAAGACA AAAGGAACTG CCTGGCCAAA GCCCTCGACG AGGTGAAGAC ATCCTTCCCT 
AGGGACATGG AGAACGACAA GGCCATGCTG ATAATGACCA TGCTGTTGGC CAAAAAAGTG 
GCCAGTCATG CACCATCTCT GCTCCGTGAC GTCTTCCGCA CGACCGTGAA CTTTATTAAC 
CAGAACCTAT TCTCCTACGT GAGGGACTTG GTTAGAAATG AGATGGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Bid ( XM_017592880.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017448369.1 Rattus norvegicus BH3 interacting domain death agonist (Bid), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa61005
Clone ID Related Accession (Same CDS sequence)	XM_017592880.1
Accession Version	XM_017592880.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 591bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	BH3-interacting domain death agonist isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACTCTG AGGTCAGCAA TGGCTCAGGC CTGGGGGCTG AGCACATCAC AAACCTGCTG 
GTGTTCGGCT TTCTCCGAAA CAATGACCGT GATTTCCACC AAGAGCTGGA GGTACTGGGG 
CAGGAGCTGC CCGTGCAGGT TTACCTGGAG GGGGACCGTG AAGACGAGCT GCAGACAGAT 
GGCAGCCGGG CTAGCCGCTC CTTCTATCAT GGAAGAATAG AGCCAGATTC TGAAAGTCAG 
GATGAAGTCA TCCACAACAT TGCCAGGCAT CTCGCCCAAG CAGGTGATGA ACTGGACCAC 
AGCATCCAGC CCACACTGGT GAGACAACTG GCCGCACAGT TCATGAACGG CAGCCTCTCG 
GAGGAAGACA AAAGGAACTG CCTGGCCAAA GCCCTCGACG AGGTGAAGAC ATCCTTCCCT 
AGGGACATGG AGAATGACAA GGCCATGCTG ATAATGACCA TGCTGTTGGC CAAAAAAGTG 
GCCAGTCATG CACCATCTCT GCTCCGTGAC GTCTTCCGCA CGACCGTGAA CTTTATTAAC 
CAGAACCTAT TCTCCTACGT GAGGGACTTG GTTAGAAATG AGATGGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017448369.1
CDS	1404..1994
Translation	MDSEVSNGSGLGAEHITNLLVFGFLRNNDRDFHQELEVLGQELPVQVYLEGDREDELQTDGSRASRSFYHGRIEPDSESQDEVIHNIARHLAQAGDELDHSIQPTLVRQLAAQFMNGSLSEEDKRNCLAKALDEVKTSFPRDMENDKAMLIMTMLLAKKVASHAPSLLRDVFRTTVNFINQNLFSYVRDLVRNEMD

Target ORF information:

RefSeq Version	XM_017592880.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus BH3 interacting domain death agonist (Bid), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017592880.1

ORF Insert Sequence:

ATGGACTCTG AGGTCAGCAA TGGCTCAGGC CTGGGGGCTG AGCACATCAC AAACCTGCTG 
GTGTTCGGCT TTCTCCGAAA CAATGACCGT GATTTCCACC AAGAGCTGGA GGTACTGGGG 
CAGGAGCTGC CCGTGCAGGT TTACCTGGAG GGGGACCGTG AAGACGAGCT GCAGACAGAT 
GGCAGCCGGG CTAGCCGCTC CTTCTATCAT GGAAGAATAG AGCCAGATTC TGAAAGTCAG 
GATGAAGTCA TCCACAACAT TGCCAGGCAT CTCGCCCAAG CAGGTGATGA ACTGGACCAC 
AGCATCCAGC CCACACTGGT GAGACAACTG GCCGCACAGT TCATGAACGG CAGCCTCTCG 
GAGGAAGACA AAAGGAACTG CCTGGCCAAA GCCCTCGACG AGGTGAAGAC ATCCTTCCCT 
AGGGACATGG AGAATGACAA GGCCATGCTG ATAATGACCA TGCTGTTGGC CAAAAAAGTG 
GCCAGTCATG CACCATCTCT GCTCCGTGAC GTCTTCCGCA CGACCGTGAA CTTTATTAAC 
CAGAACCTAT TCTCCTACGT GAGGGACTTG GTTAGAAATG AGATGGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Nuclear translocation of annexin 1 following oxygen-glucose deprivation-reperfusion induces apoptosis by regulating Bid expression via p53 binding.
Cell death & disease7(9)e2356(2016 Sep)
Li X,Zhao Y,Xia Q,Zheng L,Liu L,Zhao B,Shi J

Neonatal bronchopulmonary dysplasia increases neuronal apoptosis in the hippocampus through the HIF-1? and p53 pathways.
Respiratory physiology & neurobiology22081-7(2016 Jan)
Yin R,Yuan L,Ping L,Hu L