Galp cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Galp
Entrez Gene ID	64568
Full Name	galanin-like peptide
General protein information	Preferred Names galanin-like peptide Names galanin-like peptide
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q12

mRNA and Protein(s)

mRNA	Protein	Name
NM_022633.1	NP_072155.1	galanin-like peptide precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Galp	NP_072155.1
Homo sapiens (human)	GALP	NP_149097.1
Mus musculus (house mouse)	Galp	NP_821171.1
Canis lupus familiaris (dog)	GALP	XP_005616158.1
Pan troglodytes (chimpanzee)	GALP	XP_524495.2
	GALP	XP_001090902.1

Gene Ontology
Bibliography

Related articles in PubMed

Alarin but not its alternative-splicing form, GALP (Galanin-like peptide) has antimicrobial activity.
Wada A, Wong PF, Hojo H, Hasegawa M, Ichinose A, Llanes R, Kubo Y, Senba M, Ichinose Y
Biochemical and biophysical research communications434(2)223-7(2013 May)

Hypothalamic galanin-like peptide rescues the onset of puberty in food-restricted weanling rats.
Mohr MA, Leathley E, Fraley GS
Journal of neuroendocrinology24(11)1412-22(2012 Nov)

Galanin-like peptide stimulates feeding and sexual behavior via dopaminergic fibers within the medial preoptic area of adult male rats.
Taylor A, Madison FN, Fraley GS
Journal of chemical neuroanatomy37(2)105-11(2009 Mar)

Altered response to metabolic challenges in mice with genetically targeted deletions of galanin-like peptide.
Dungan Lemko HM, Clifton DK, Steiner RA, Fraley GS
American journal of physiology. Endocrinology and metabolism295(3)E605-12(2008 Sep)

Postnatal development of galanin-like peptide mRNA expression in rat hypothalamus.
Kawagoe R, Yamamoto Y, Kubo K, Dobashi K, Asayama K, Ueta Y, Shirahata A
Regulatory peptides145(1-3)133-40(2008 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Hypothalamic galanin-like peptide rescues the onset of puberty in food-restricted weanling rats.
Title: Hypothalamic galanin-like peptide rescues the onset of puberty in food-restricted weanling rats.

These data suggest that GALP activates feeding and sexual behaviors in male rats by stimulating dopaminergic neurons that terminate within the mPOA.
Title: Galanin-like peptide stimulates feeding and sexual behavior via dopaminergic fibers within the medial preoptic area of adult male rats.

GALP-containing neurons innervate tuberoinfundibular dopaminergic neurons
Title: Morphological interaction between galanin-like peptide- and dopamine-containing neurons in the rat arcuate nucleus.

regulatory mechanism of GALP mRNA is different from that of the neuropeptide Y and proopiomelanocortin genes during postnatal development
Title: Postnatal development of galanin-like peptide mRNA expression in rat hypothalamus.

These results showed that acute osmotic stimulus-induced GALP gene expression in the pituicyte of the PP, but not in the neurons in the Arc, and the gene expression in the pituicyte is regulated by plasma osmolality and/or plasma sodium concentration.
Title: Induction of the galanin-like peptide gene expression in the posterior pituitary gland after acute osmotic stimulus in rats.

The following Galp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Galp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13080	NM_022633.1 Latest version!	Rattus norvegicus galanin-like peptide (Galp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Galp ( NM_022633.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_072155.1 Rattus norvegicus galanin-like peptide (Galp), mRNA.

Price & Availability↑

CloneID	ORa13080
Clone ID Related Accession (Same CDS sequence)	NM_022633.1
Accession Version	NM_022633.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 348bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	galanin-like peptide precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF188491.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF188491.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052297 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END##

ATGGCCTGCT CCAAGCATCT GGTCCTCTTC CTCACCATCT TGCTAAGCCT CGCAGAAACA 
CCAGACTCTG CACCTGCTCA CAGGGGACGA GGAGGCTGGA CCCTCAATAG TGCTGGTTAC 
CTCCTGGGTC CTGTCCTCCA CCTTTCCTCA AAGGCCAACC AGGGCAGGAA GACAGACTCA 
GCTCTTGAGA TCCTAGACCT GTGGAAGGCC ATAGATGGGC TCCCTTATTC CCGCTCTCCA 
AGGATGACCA AAAGGTCAAT GGGAGAAACG TTTGTCAAGC CGAGGACTGG AGATCTGCGC 
ATAGTGGACA AGAATGTTCC GGATGAAGAA GCCACCCTGA ACTTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_072155.1
CDS	126..473
Translation	MACSKHLVLFLTILLSLAETPDSAPAHRGRGGWTLNSAGYLLGPVLHLSSKANQGRKTDSALEILDLWKAIDGLPYSRSPRMTKRSMGETFVKPRTGDLRIVDKNVPDEEATLNL

Target ORF information:

RefSeq Version	NM_022633.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus galanin-like peptide (Galp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022633.1

ORF Insert Sequence:

ATGGCCTGCT CCAAGCATCT GGTCCTCTTC CTCACCATCT TGCTAAGCCT CGCAGAAACA 
CCAGACTCTG CACCTGCTCA CAGGGGACGA GGAGGCTGGA CCCTCAATAG TGCTGGTTAC 
CTCCTGGGTC CTGTCCTCCA CCTTTCCTCA AAGGCCAACC AGGGCAGGAA GACAGACTCA 
GCTCTTGAGA TCCTAGACCT GTGGAAGGCC ATAGATGGGC TCCCTTATTC CCGCTCTCCA 
AGGATGACCA AAAGGTCAAT GGGAGAAACG TTTGTCAAGC CGAGGACTGG AGATCTGCGC 
ATAGTGGACA AGAATGTTCC GGATGAAGAA GCCACCCTGA ACTTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Alarin but not its alternative-splicing form, GALP (Galanin-like peptide) has antimicrobial activity.
Biochemical and biophysical research communications434(2)223-7(2013 May)
Wada A,Wong PF,Hojo H,Hasegawa M,Ichinose A,Llanes R,Kubo Y,Senba M,Ichinose Y

Hypothalamic galanin-like peptide rescues the onset of puberty in food-restricted weanling rats.
Journal of neuroendocrinology24(11)1412-22(2012 Nov)
Mohr MA,Leathley E,Fraley GS

Galanin-like peptide stimulates feeding and sexual behavior via dopaminergic fibers within the medial preoptic area of adult male rats.
Journal of chemical neuroanatomy37(2)105-11(2009 Mar)
Taylor A,Madison FN,Fraley GS

Altered response to metabolic challenges in mice with genetically targeted deletions of galanin-like peptide.
American journal of physiology. Endocrinology and metabolism295(3)E605-12(2008 Sep)
Dungan Lemko HM,Clifton DK,Steiner RA,Fraley GS

Postnatal development of galanin-like peptide mRNA expression in rat hypothalamus.
Regulatory peptides145(1-3)133-40(2008 Jan)
Kawagoe R,Yamamoto Y,Kubo K,Dobashi K,Asayama K,Ueta Y,Shirahata A