Inhbc cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Inhbc
Entrez Gene ID	64549
Full Name	inhibin beta C subunit
General protein information	Preferred Names inhibin beta C subunit Names inhibin beta C chain activin beta-C chain activin/inhibin beta C
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q22
Summary	cytokines which play a central role in the determination of cell fate and the regulation of tissue differentiation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_022614.2	NP_072136.1	inhibin beta C chain precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	INHBC	NP_005529.1
Canis lupus familiaris (dog)	INHBC	XP_849169.2
Rattus norvegicus (Norway rat)	Inhbc	NP_072136.1
	INHBC	XP_001115940.1
Xenopus tropicalis (tropical clawed frog)	LOC100493888	XP_002939470.1
Bos taurus (cattle)	INHBC	NP_001192912.1
Pan troglodytes (chimpanzee)	INHBC	XP_522443.1
Mus musculus (house mouse)	Inhbc	NP_034695.1

Gene Ontology
Bibliography

Related articles in PubMed

Adenovirus-mediated overexpression of the activin betaC subunit accelerates liver regeneration in partially hepatectomized rats.
Wada W, Medina J, Hasegawa Y, Kuwano H, Kojima I
Journal of hepatology43(5)823-8(2005 Nov)

betaA- and betaC-activin, follistatin, activin receptor mRNA and betaC-activin peptide expression during rat liver regeneration.
Gold EJ, Zhang X, Wheatley AM, Mellor SL, Cranfield M, Risbridger GP, Groome NP, Fleming JS
Journal of molecular endocrinology34(2)505-15(2005 Apr)

Overexpression of activin beta(C) or activin beta(E) in the mouse liver inhibits regenerative deoxyribonucleic acid synthesis of hepatic cells.
Chabicovsky M, Herkner K, Rossmanith W
Endocrinology144(8)3497-504(2003 Aug)

Expression and dimerization of the rat activin subunits betaC and betaE: evidence for the ormation of novel activin dimers.
Vejda S, Cranfield M, Peter B, Mellor SL, Groome N, Schulte-Hermann R, Rossmanith W
Journal of molecular endocrinology28(2)137-48(2002 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results indicate that liver regeneration is accelerated in activin betaC-overexpressing liver, and that betaC may function to promote replication of hepatocytes during liver regeneration.
Title: Adenovirus-mediated overexpression of the activin betaC subunit accelerates liver regeneration in partially hepatectomized rats.

Data suggest that betaA- and betaC-activin subunit proteins and follistatin are autocrine growth regulators in regenerating liver and when expressed independently lead to hepatocyte apoptosis or mitosis in a subset of hepatocytes.
Title: betaA- and betaC-activin, follistatin, activin receptor mRNA and betaC-activin peptide expression during rat liver regeneration.

first report of a biological activity of activin C and E supports an involvement in liver tissue homeostasis
Title: Overexpression of activin beta(C) or activin beta(E) in the mouse liver inhibits regenerative deoxyribonucleic acid synthesis of hepatic cells.

Expression and dimerization of the rat activin subunits betaC and betaE: evidence for the ormation of novel activin dimers.
Title: Expression and dimerization of the rat activin subunits betaC and betaE: evidence for the ormation of novel activin dimers.

The following Inhbc gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Inhbc cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06130	NM_022614.2 Latest version!	Rattus norvegicus inhibin subunit beta C (Inhbc), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Inhbc ( NM_022614.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_072136.1 Rattus norvegicus inhibin subunit beta C (Inhbc), mRNA.

Price & Availability↑

CloneID	ORa06130
Clone ID Related Accession (Same CDS sequence)	NM_022614.2
Accession Version	NM_022614.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1056bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	inhibin beta C chain precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC089799.1. On Feb 13, 2005 this sequence version replaced NM_022614.1. ##Evidence-Data-START## Transcript exon combination :: BC089799.1, AF140031.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689598, SAMN01906347 [ECO:0000348] ##Evidence-Data-END##

ATGGCCTCCT CCTTGCTCCT GGCTCTTCTG TTCCTGACTC TAGCCACAGT AGTGAACCTC 
AAAACTGATG GTCCATGTCC AGCATGTTGG GGTGCCACCT TTGACCTGGA GAGCCATCGG 
GAGCTCCTTC TCGATTTGGC CAAGAAAAGC ATCCTGGACA AGCTGCACCT CAGCCAGCGC 
CCCATACTCA GTCGGCCTGT GTCCAGAGAG GCCCTCAAGA CCGCGCTGCG GCGCCTCCGT 
GGGACTCGAG CGGAAACCCT GTTGGAGCAT GACCAGAGAC AAGAATATGA GATCATCAGC 
TTTGCTGACA CAGGCCTCTC CAACATCAAC CAAACCCGTC TTGAATTCCA TTTCTCTGAT 
AGAACTACTG GTGGTGTGGA GGTCCTGCAG ACCCGTTTCA TGTTCTTCAT GCAGCTCCCT 
CCCAACACCA CCCAGACCAT GAATATAAGA GTTCTTGTGC TAAGGCCATA TGACACCAAC 
CTCACCTTGA CAAGCCAGTA CATGCTGCAG GTGGATGCCA GTGGCTGGTA CCAGCTTCTC 
CTAGGACCCG AAGCTCAAGC TGCTTGCAGT CAGGGGCACC TCACTCTGGA GCTGGTGCCA 
GAAAGTCAGC TGGCCCACAG TTCCTTGATC CTGGATGGGG TTTCCCACAG GCCTTTTGTG 
GCAGCCCAGG TAAGAGTTGA AGGCAAGCAT CGGGTACGCC GGCGAGGTAT CAACTGCCAG 
GGGCTGTCCA GGATGTGCTG TCGGCAAGAG TTCTTTGTGG ACTTCCGTGA GATTGGCTGG 
CATGACTGGA TCATCCAGCC CGAAGGCTAT GCCATGAACT TCTGCACTGG GCAGTGCCCA 
CTACATGTGG CAGGCATGCC TGGCATCTCT GCGTCCTTTC ACACTGCAGT GCTGAATCTG 
CTCAAAGCCA ACACAGATGC TGGCACTGCC CGCAGGGGCT CATGCTGCGT GCCTACGTCT 
CGGCGCCCTC TGTCTTTGCT CTACTATGAC AGGGACAGCA ACATTGTCAA GACGGATATA 
CCTGACATGG TGGTAGAGGC CTGTGGGTGC AGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_072136.1
CDS	94..1149
Translation	MASSLLLALLFLTLATVVNLKTDGPCPACWGATFDLESHRELLLDLAKKSILDKLHLSQRPILSRPVSREALKTALRRLRGTRAETLLEHDQRQEYEIISFADTGLSNINQTRLEFHFSDRTTGGVEVLQTRFMFFMQLPPNTTQTMNIRVLVLRPYDTNLTLTSQYMLQVDASGWYQLLLGPEAQAACSQGHLTLELVPESQLAHSSLILDGVSHRPFVAAQVRVEGKHRVRRRGINCQGLSRMCCRQEFFVDFREIGWHDWIIQPEGYAMNFCTGQCPLHVAGMPGISASFHTAVLNLLKANTDAGTARRGSCCVPTSRRPLSLLYYDRDSNIVKTDIPDMVVEACGCS

Target ORF information:

RefSeq Version	NM_022614.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus inhibin subunit beta C (Inhbc), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022614.2

ORF Insert Sequence:

ATGGCCTCCT CCTTGCTCCT GGCTCTTCTG TTCCTGACTC TAGCCACAGT AGTGAACCTC 
AAAACTGATG GTCCATGTCC AGCATGTTGG GGTGCCACCT TTGACCTGGA GAGCCATCGG 
GAGCTCCTTC TCGATTTGGC CAAGAAAAGC ATCCTGGACA AGCTGCACCT CAGCCAGCGC 
CCCATACTCA GTCGGCCTGT GTCCAGAGAG GCCCTCAAGA CCGCGCTGCG GCGCCTCCGT 
GGGACTCGAG CGGAAACCCT GTTGGAGCAT GACCAGAGAC AAGAATATGA GATCATCAGC 
TTTGCTGACA CAGGCCTCTC CAACATCAAC CAAACCCGTC TTGAATTCCA TTTCTCTGAT 
AGAACTACTG GTGGTGTGGA GGTCCTGCAG ACCCGTTTCA TGTTCTTCAT GCAGCTCCCT 
CCCAACACCA CCCAGACCAT GAATATAAGA GTTCTTGTGC TAAGGCCATA TGACACCAAC 
CTCACCTTGA CAAGCCAGTA CATGCTGCAG GTGGATGCCA GTGGCTGGTA CCAGCTTCTC 
CTAGGACCCG AAGCTCAAGC TGCTTGCAGT CAGGGGCACC TCACTCTGGA GCTGGTGCCA 
GAAAGTCAGC TGGCCCACAG TTCCTTGATC CTGGATGGGG TTTCCCACAG GCCTTTTGTG 
GCAGCCCAGG TAAGAGTTGA AGGCAAGCAT CGGGTACGCC GGCGAGGTAT CAACTGCCAG 
GGGCTGTCCA GGATGTGCTG TCGGCAAGAG TTCTTTGTGG ACTTCCGTGA GATTGGCTGG 
CATGACTGGA TCATCCAGCC CGAAGGCTAT GCCATGAACT TCTGCACTGG GCAGTGCCCA 
CTACATGTGG CAGGCATGCC TGGCATCTCT GCGTCCTTTC ACACTGCAGT GCTGAATCTG 
CTCAAAGCCA ACACAGATGC TGGCACTGCC CGCAGGGGCT CATGCTGCGT GCCTACGTCT 
CGGCGCCCTC TGTCTTTGCT CTACTATGAC AGGGACAGCA ACATTGTCAA GACGGATATA 
CCTGACATGG TGGTAGAGGC CTGTGGGTGC AGTTAG