Esm1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Esm1
Entrez Gene ID	64536
Full Name	endothelial cell-specific molecule 1
Synonyms	Pg25
General protein information	Preferred Names endothelial cell-specific molecule 1 Names endothelial cell-specific molecule 1 ESM-1 secretory protein pineal specific PG25 protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q14
Summary	secreted protein mainly expressed in endothelial cells; may be involved in lung-kidney interaction [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_022604.2	NP_072126.1	endothelial cell-specific molecule 1 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	ESM1	NP_001091570.1
Gallus gallus (chicken)	ESM1	XP_428357.3
Danio rerio (zebrafish)	esm1	NP_001070209.1
Xenopus tropicalis (tropical clawed frog)	esm1	NP_001120192.1
Homo sapiens (human)	ESM1	NP_008967.1
Pan troglodytes (chimpanzee)	ESM1	XP_518187.3
Canis lupus familiaris (dog)	ESM1	XP_546319.2
	ESM1	XP_001097123.2
Mus musculus (house mouse)	Esm1	NP_076101.1
Rattus norvegicus (Norway rat)	Esm1	NP_072126.1

Gene Ontology
Bibliography

Related articles in PubMed

Detection and mechanism of action of ESM-1 in rat kidney transplantation under various immune states.
Li S, Liang P, Zhao Y, Li X, Hu Y, Wu W, Li Y, Zhou P, Wang Q, Yang W, Wang L, Wang Q, Yang H, Cheng W, Chao W, Zhang B, Jin F
Cellular immunology283(1-2)31-7(2013 May-Jun)

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis.
Br?tsch R, Liebler SS, W?stehube J, Bartol A, Herberich SE, Adam MG, Telzerow A, Augustin HG, Fischer A
Circulation research107(5)592-601(2010 Sep)

Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM.
Aitkenhead M, Wang SJ, Nakatsu MN, Mestas J, Heard C, Hughes CC
Microvascular research63(2)159-71(2002 Mar)

Endocan is a novel chondroitin sulfate/dermatan sulfate proteoglycan that promotes hepatocyte growth factor/scatter factor mitogenic activity.
B?chard D, Gentina T, Delehedde M, Scherpereel A, Lyon M, Aumercier M, Vazeux R, Richet C, Degand P, Jude B, Janin A, Fernig DG, Tonnel AB, Lassalle P
The Journal of biological chemistry276(51)48341-9(2001 Dec)

Human endothelial-cell specific molecule-1 binds directly to the integrin CD11a/CD18 (LFA-1) and blocks binding to intercellular adhesion molecule-1.
B?chard D, Scherpereel A, Hammad H, Gentina T, Tsicopoulos A, Aumercier M, Pestel J, Dessaint JP, Tonnel AB, Lassalle P
Journal of immunology (Baltimore, Md. : 1950)167(6)3099-106(2001 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Peripheral blood ESM-1 mRNA and ESM-1 protein expression in kidney grafts can reflect the severity of endothelial cell impairment
Title: Detection and mechanism of action of ESM-1 in rat kidney transplantation under various immune states.

The following Esm1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Esm1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06108	NM_022604.2 Latest version!	Rattus norvegicus endothelial cell-specific molecule 1 (Esm1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Esm1 ( NM_022604.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_072126.1 Rattus norvegicus endothelial cell-specific molecule 1 (Esm1), mRNA.

Price & Availability↑

CloneID	ORa06108
Clone ID Related Accession (Same CDS sequence)	NM_022604.2
Accession Version	NM_022604.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 555bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	endothelial cell-specific molecule 1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC070888.1. On May 24, 2004 this sequence version replaced NM_022604.1. ##Evidence-Data-START## Transcript exon combination :: BC070888.1, CK473736.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAAGAGCC TCTTGCTACT GACCACGCTC CTGATTCCTC TGCACCTGGG CATGGCCTGG 
AGCGCCAAGT ATGCGGTGGA TTGCCCGGAA CATTGTGACA ATACTGAGTG CAGAAGCAGC 
CTGCGTTGCA AGAGGACAGT GCTGGATGAC TGTGGCTGCT GCCAAGTGTG CGCTGCGGGG 
CCTGGGGAAA CCTGCTACCG TACAGTCTCA GGCATGGACG GTGTCAAGTG TGGTCCGGGA 
CTGAAGTGTC ACTTTTACAG CGAGGAAGAT GATTTCGGTG ACGAGTTTGG TGTCTGTAAA 
GACTGTCCCT ACGGCACGTT CGGGATGGAT TGCAAGGAGA CTTGCAATTG CCAGTCGGGC 
ATATGTGACA GGGTGACCGG GAGGTGTCTG GACTTCCCCT TCTTCCAGTA TGCAGCAGCC 
AAGTCGCCCA GCAGGACCTC TGCCTCCCAA ACAGAGCGCG ATGCAGCCTC TGGAGATGGC 
AATGCTGTGA GAGAAGAGAT TGGAGACCGG AACGCTGCCC GGCCCTCTGT AATGAAATGG 
TTAAATCCGC GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_072126.1
CDS	138..692
Translation	MKSLLLLTTLLIPLHLGMAWSAKYAVDCPEHCDNTECRSSLRCKRTVLDDCGCCQVCAAGPGETCYRTVSGMDGVKCGPGLKCHFYSEEDDFGDEFGVCKDCPYGTFGMDCKETCNCQSGICDRVTGRCLDFPFFQYAAAKSPSRTSASQTERDAASGDGNAVREEIGDRNAARPSVMKWLNPR

Target ORF information:

RefSeq Version	NM_022604.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus endothelial cell-specific molecule 1 (Esm1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022604.2

ORF Insert Sequence:

ATGAAGAGCC TCTTGCTACT GACCACGCTC CTGATTCCTC TGCACCTGGG CATGGCCTGG 
AGCGCCAAGT ATGCGGTGGA TTGCCCGGAA CATTGTGACA ATACTGAGTG CAGAAGCAGC 
CTGCGTTGCA AGAGGACAGT GCTGGATGAC TGTGGCTGCT GCCAAGTGTG CGCTGCGGGG 
CCTGGGGAAA CCTGCTACCG TACAGTCTCA GGCATGGACG GTGTCAAGTG TGGTCCGGGA 
CTGAAGTGTC ACTTTTACAG CGAGGAAGAT GATTTCGGTG ACGAGTTTGG TGTCTGTAAA 
GACTGTCCCT ACGGCACGTT CGGGATGGAT TGCAAGGAGA CTTGCAATTG CCAGTCGGGC 
ATATGTGACA GGGTGACCGG GAGGTGTCTG GACTTCCCCT TCTTCCAGTA TGCAGCAGCC 
AAGTCGCCCA GCAGGACCTC TGCCTCCCAA ACAGAGCGCG ATGCAGCCTC TGGAGATGGC 
AATGCTGTGA GAGAAGAGAT TGGAGACCGG AACGCTGCCC GGCCCTCTGT AATGAAATGG 
TTAAATCCGC GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Detection and mechanism of action of ESM-1 in rat kidney transplantation under various immune states.
Cellular immunology283(1-2)31-7(2013 May-Jun)
Li S,Liang P,Zhao Y,Li X,Hu Y,Wu W,Li Y,Zhou P,Wang Q,Yang W,Wang L,Wang Q,Yang H,Cheng W,Chao W,Zhang B,Jin F

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis.
Circulation research107(5)592-601(2010 Sep)
Br?tsch R,Liebler SS,W?stehube J,Bartol A,Herberich SE,Adam MG,Telzerow A,Augustin HG,Fischer A

Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM.
Microvascular research63(2)159-71(2002 Mar)
Aitkenhead M,Wang SJ,Nakatsu MN,Mestas J,Heard C,Hughes CC

Endocan is a novel chondroitin sulfate/dermatan sulfate proteoglycan that promotes hepatocyte growth factor/scatter factor mitogenic activity.
The Journal of biological chemistry276(51)48341-9(2001 Dec)
B?chard D,Gentina T,Delehedde M,Scherpereel A,Lyon M,Aumercier M,Vazeux R,Richet C,Degand P,Jude B,Janin A,Fernig DG,Tonnel AB,Lassalle P

Human endothelial-cell specific molecule-1 binds directly to the integrin CD11a/CD18 (LFA-1) and blocks binding to intercellular adhesion molecule-1.
Journal of immunology (Baltimore, Md. : 1950)167(6)3099-106(2001 Sep)
B?chard D,Scherpereel A,Hammad H,Gentina T,Tsicopoulos A,Aumercier M,Pestel J,Dessaint JP,Tonnel AB,Lassalle P