Des cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Des
Entrez Gene ID	64362
Full Name	desmin
General protein information	Preferred Names desmin Names desmin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q33
Summary	class II intermediate filament protein, localized to muscle cells, may be a differentiation marker for muscle cells [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_022531.1	NP_071976.1	desmin

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	DES	XP_526039.2
Canis lupus familiaris (dog)	DES	NP_001012394.1
Bos taurus (cattle)	DES	NP_001075044.1
Rattus norvegicus (Norway rat)	Des	NP_071976.1
Gallus gallus (chicken)	DES	XP_004942895.1
Homo sapiens (human)	DES	NP_001918.3
	DES	XP_001104181.1
Xenopus tropicalis (tropical clawed frog)	des.1	NP_989134.1
Mus musculus (house mouse)	Des	NP_034173.1

Gene Ontology
Bibliography

Related articles in PubMed

The Novel Desmin Mutation p.Glu401Asp Impairs Filament Formation, Disrupts Cell Membrane Integrity and Causes Severe Arrhythmogenic Left Ventricular Cardiomyopathy/Dysplasia.
Berm?dez-Jim?nez FJ, Carriel V, Brodehl A, Alaminos M, Campos A, Schirmer I, Milting H, ?lvarez Abril B, ?lvarez M, L?pez-Fern?ndez S, Garc?a-Giustiniani D, Monserrat L, Tercedor L, Jim?nez-J?imez J
Circulation(2017 Dec)

Desmin loss and mitochondrial damage precede left ventricular systolic failure in volume overload heart failure.
Guichard JL, Rogowski M, Agnetti G, Fu L, Powell P, Wei CC, Collawn J, Dell'Italia LJ
American journal of physiology. Heart and circulatory physiology313(1)H32-H45(2017 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study provides new evidence of early onset (24 h) and continuous (4-12 wk) desmin misarrangement and disruption of the normal sarcomeric and mitochondrial architecture throughout the progression of volume overload heart failure, suggesting a causal link between desmin cleavage and mitochondrial disorganization and damage.
Title: Desmin loss and mitochondrial damage precede left ventricular systolic failure in volume overload heart failure.

Data indicte that desmin and h1-calponin are expressed in mesenchymal stem cells (MSC).
Title: Differentiated markers in undifferentiated cells: expression of smooth muscle contractile proteins in multipotent bone marrow mesenchymal stem cells.

Desmin and alpha-actinin-2 content in rat soleus muscle in the dynamics of gravitational unloading and subsequent reloading.
Title: Desmin and ?-actinin-2 content in rat soleus muscle in the dynamics of gravitational unloading and subsequent reloading.

Following phosphorylation at Ser15 during reloading and regrowing of soleus muscle, HSP25 contributes to desmin cytoskeletal organization.
Title: HSP25 can modulate myofibrillar desmin cytoskeleton following the phosphorylation at Ser15 in rat soleus muscle.

tetanic contractions induce an over-activation of calpains which lead to higher degrees of desmin degradation in unloaded soleus muscle
Title: Tetanic contractions impair sarcomeric Z-disk of atrophic soleus muscle via calpain pathway.

The following Des gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Des cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05862	NM_022531.1 Latest version!	Rattus norvegicus desmin (Des), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$279.30 $399.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Des ( NM_022531.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_071976.1 Rattus norvegicus desmin (Des), mRNA.

Price & Availability↑

CloneID	ORa05862
Clone ID Related Accession (Same CDS sequence)	NM_022531.1
Accession Version	NM_022531.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1410bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-10
Organism	Rattus norvegicus(Norway rat)
Product	desmin
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X73524.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FQ214848.1, BC061872.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAGCCAGG CCTACTCGTC CAGCCAGCGC GTGTCCTCCT ACCGCCGCAC CTTCGGCGGC 
GCCCCGGGCT TCTCGCTCGG TTCCCCGCTG AGCTCTCCGG TGTTCCCACG AGCAGGCTTC 
GGTACCAAGG GCTCCTCGAG CTCAGTGACA TCCCGCGTGT ACCAGGTGTC GCGCACGTCG 
GGCGGGGCCG GAGGCTTGGG GTCGCTGCGG GCTAGCCGGC TGGGGACCAC CCGAGCACCA 
TCCTATGGCG CGGGCGAGCT GCTGGACTTC TCGCTGGCCG ACGCAGTGAA CCAGGAGTTC 
CTGGCCACGC GCACCAACGA GAAGGTGGAG CTGCAAGAGC TCAATGACCG CTTCGCCAAC 
TACTTCGAGA AGGTGCGCTT TTTGGAACAG CAGAACGCCG CGCTCGCCGC CGAGGTCAAC 
CGGCTCAAGG GCCGAGAGCC GACTCGGGTC GCCGAGCTCT ACGAGGAGGA GATGCGAGAG 
CTGCGGCGCC AAGTGGAGGT CCTCACCAAC CAGCGCGCCC GCGTCGACGT GGAGCGTGAC 
AACCTGATAG ACGACCTGCA GAGGCTCAAG GCCAAGCTAC AGGAGGAAAT CCAACTGAGA 
GAAGAAGCAG AGAACAACTT GGCTGCCTTC CGAGCGGATG TGGATGCAGC CACTCTGGCT 
CGAATTGACC TAGAGCGCAG AATTGAGTCA CTCAACGAGG AGATTGCATT CCTTAAGAAA 
GTGCACGAAG AGGAGATCCG TGAGCTCCAG GCCCAGCTTC AGGAACAGCA GGTCCAGGTA 
GAGATGGACA TGTCCAAGCC AGACCTCACA GCCGCCCTCA GGGACATCCG TGCTCAGTAT 
GAGACCATTG CGGCTAAGAA CATCTCTGAG GCTGAAGAAT GGTACAAGTC CAAGGTTTCA 
GACTTGACTC AGGCAGCCAA TAAGAACAAC GATGCGCTGC GCCAAGCCAA GCAGGAGATG 
ATGGAATACC GACACCAGAT CCAGTCCTAC ACCTGCGAGA TTGATGCTCT CAAGGGCACC 
AACGACTCCT TGATGAGGCA GATGAGGGAG CTGGAGGATC GCTTCGCCAG CGAGGCCAGT 
GGCTATCAGG ACAACATCGC GCGCCTGGAG GAGGAGATCC GACACCTAAA GGATGAGATG 
GCCCGCCATC TGCGGGAGTA CCAGGATCTG CTCAATGTGA AGATGGCCTT GGATGTGGAG 
ATTGCCACCT ACCGGAAGCT GCTGGAGGGC GAGGAGAGCA GGATCAACCT TCCGATCCAG 
ACCTTCTCTG CTCTCAACTT CCGAGAAACC AGCCCTGAGC AAAGGGGTTC CGAAGTCCAC 
ACCAAAAAGA CAGTGATGAT CAAGACCATT GAGACCCGGG ATGGAGAGGT CGTCAGCGAG 
GCCACACAGC AACAACATGA AGTGCTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071976.1
CDS	79..1488
Translation	MSQAYSSSQRVSSYRRTFGGAPGFSLGSPLSSPVFPRAGFGTKGSSSSVTSRVYQVSRTSGGAGGLGSLRASRLGTTRAPSYGAGELLDFSLADAVNQEFLATRTNEKVELQELNDRFANYFEKVRFLEQQNAALAAEVNRLKGREPTRVAELYEEEMRELRRQVEVLTNQRARVDVERDNLIDDLQRLKAKLQEEIQLREEAENNLAAFRADVDAATLARIDLERRIESLNEEIAFLKKVHEEEIRELQAQLQEQQVQVEMDMSKPDLTAALRDIRAQYETIAAKNISEAEEWYKSKVSDLTQAANKNNDALRQAKQEMMEYRHQIQSYTCEIDALKGTNDSLMRQMRELEDRFASEASGYQDNIARLEEEIRHLKDEMARHLREYQDLLNVKMALDVEIATYRKLLEGEESRINLPIQTFSALNFRETSPEQRGSEVHTKKTVMIKTIETRDGEVVSEATQQQHEVL

Target ORF information:

RefSeq Version	NM_022531.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus desmin (Des), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022531.1

ORF Insert Sequence:

ATGAGCCAGG CCTACTCGTC CAGCCAGCGC GTGTCCTCCT ACCGCCGCAC CTTCGGCGGC 
GCCCCGGGCT TCTCGCTCGG TTCCCCGCTG AGCTCTCCGG TGTTCCCACG AGCAGGCTTC 
GGTACCAAGG GCTCCTCGAG CTCAGTGACA TCCCGCGTGT ACCAGGTGTC GCGCACGTCG 
GGCGGGGCCG GAGGCTTGGG GTCGCTGCGG GCTAGCCGGC TGGGGACCAC CCGAGCACCA 
TCCTATGGCG CGGGCGAGCT GCTGGACTTC TCGCTGGCCG ACGCAGTGAA CCAGGAGTTC 
CTGGCCACGC GCACCAACGA GAAGGTGGAG CTGCAAGAGC TCAATGACCG CTTCGCCAAC 
TACTTCGAGA AGGTGCGCTT TTTGGAACAG CAGAACGCCG CGCTCGCCGC CGAGGTCAAC 
CGGCTCAAGG GCCGAGAGCC GACTCGGGTC GCCGAGCTCT ACGAGGAGGA GATGCGAGAG 
CTGCGGCGCC AAGTGGAGGT CCTCACCAAC CAGCGCGCCC GCGTCGACGT GGAGCGTGAC 
AACCTGATAG ACGACCTGCA GAGGCTCAAG GCCAAGCTAC AGGAGGAAAT CCAACTGAGA 
GAAGAAGCAG AGAACAACTT GGCTGCCTTC CGAGCGGATG TGGATGCAGC CACTCTGGCT 
CGAATTGACC TAGAGCGCAG AATTGAGTCA CTCAACGAGG AGATTGCATT CCTTAAGAAA 
GTGCACGAAG AGGAGATCCG TGAGCTCCAG GCCCAGCTTC AGGAACAGCA GGTCCAGGTA 
GAGATGGACA TGTCCAAGCC AGACCTCACA GCCGCCCTCA GGGACATCCG TGCTCAGTAT 
GAGACCATTG CGGCTAAGAA CATCTCTGAG GCTGAAGAAT GGTACAAGTC CAAGGTTTCA 
GACTTGACTC AGGCAGCCAA TAAGAACAAC GATGCGCTGC GCCAAGCCAA GCAGGAGATG 
ATGGAATACC GACACCAGAT CCAGTCCTAC ACCTGCGAGA TTGATGCTCT CAAGGGCACC 
AACGACTCCT TGATGAGGCA GATGAGGGAG CTGGAGGATC GCTTCGCCAG CGAGGCCAGT 
GGCTATCAGG ACAACATCGC GCGCCTGGAG GAGGAGATCC GACACCTAAA GGATGAGATG 
GCCCGCCATC TGCGGGAGTA CCAGGATCTG CTCAATGTGA AGATGGCCTT GGATGTGGAG 
ATTGCCACCT ACCGGAAGCT GCTGGAGGGC GAGGAGAGCA GGATCAACCT TCCGATCCAG 
ACCTTCTCTG CTCTCAACTT CCGAGAAACC AGCCCTGAGC AAAGGGGTTC CGAAGTCCAC 
ACCAAAAAGA CAGTGATGAT CAAGACCATT GAGACCCGGG ATGGAGAGGT CGTCAGCGAG 
GCCACACAGC AACAACATGA AGTGCTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Novel Desmin Mutation p.Glu401Asp Impairs Filament Formation, Disrupts Cell Membrane Integrity and Causes Severe Arrhythmogenic Left Ventricular Cardiomyopathy/Dysplasia.
Circulation(2017 Dec)
Berm?dez-Jim?nez FJ,Carriel V,Brodehl A,Alaminos M,Campos A,Schirmer I,Milting H,?lvarez Abril B,?lvarez M,L?pez-Fern?ndez S,Garc?a-Giustiniani D,Monserrat L,Tercedor L,Jim?nez-J?imez J

Desmin loss and mitochondrial damage precede left ventricular systolic failure in volume overload heart failure.
American journal of physiology. Heart and circulatory physiology313(1)H32-H45(2017 Jul)
Guichard JL,Rogowski M,Agnetti G,Fu L,Powell P,Wei CC,Collawn J,Dell'Italia LJ

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Des cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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