Sncg cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sncg
Entrez Gene ID	64347
Full Name	synuclein, gamma
General protein information	Preferred Names synuclein, gamma Names gamma-synuclein persyn sensory neuron synuclein synuclein, gamma (breast cancer-specific protein 1)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16p15
Summary	may play a role in the neurofilament network [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031688.1	NP_113876.1	gamma-synuclein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SNCG	XP_507891.2
	SNCG	XP_001083650.1
Bos taurus (cattle)	SNCG	NP_776611.1
Canis lupus familiaris (dog)	SNCG	XP_005619498.1
Rattus norvegicus (Norway rat)	Sncg	NP_113876.1
Homo sapiens (human)	SNCG	NP_003078.2
Mus musculus (house mouse)	Sncg	NP_035560.1
Gallus gallus (chicken)	SNCG	NP_990003.1
Danio rerio (zebrafish)	sncgb	NP_001018488.1
Danio rerio (zebrafish)	sncga	NP_001017567.1
Xenopus tropicalis (tropical clawed frog)	sncg	NP_001016102.1

Gene Ontology
Bibliography

Related articles in PubMed

A decrease in gamma-synuclein expression within the nucleus accumbens increases cocaine intravenous self-administration in the rat.
Boyer F, Balado E, Piazza PV, Dreyer JL, Deroche-Gamonet V
Addiction biology16(1)120-3(2011 Jan)

???-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction.
Greten-Harrison B, Polydoro M, Morimoto-Tomita M, Diao L, Williams AM, Nie EH, Makani S, Tian N, Castillo PE, Buchman VL, Chandra SS
Proceedings of the National Academy of Sciences of the United States of America107(45)19573-8(2010 Nov)

Association of alpha-, beta-, and gamma-Synuclein with diffuse lewy body disease.
Nishioka K, Wider C, Vilari?o-G?ell C, Soto-Ortolaza AI, Lincoln SJ, Kachergus JM, Jasinska-Myga B, Ross OA, Rajput A, Robinson CA, Ferman TJ, Wszolek ZK, Dickson DW, Farrer MJ
Archives of neurology67(8)970-5(2010 Aug)

Enrichment and site mapping of O-linked N-acetylglucosamine by a combination of chemical/enzymatic tagging, photochemical cleavage, and electron transfer dissociation mass spectrometry.
Wang Z, Udeshi ND, O'Malley M, Shabanowitz J, Hunt DF, Hart GW
Molecular & cellular proteomics : MCP9(1)153-60(2010 Jan)

Desipramine induced changes in the norepinephrine transporter, alpha- and gamma-synuclein in the hippocampus, amygdala and striatum.
Jeannotte AM, McCarthy JG, Sidhu A
Neuroscience letters467(2)86-9(2009 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The present data reveal that GSyn exert a specific negative control on cocaine-induced reinforcing and incentive effects.
Title: A decrease in gamma-synuclein expression within the nucleus accumbens increases cocaine intravenous self-administration in the rat.

Studies characterized sites of GlcNAcylation on neuronal proteins tau, synucleins, and methyl CpG-binding protein 2.
Title: Enrichment and site mapping of O-linked N-acetylglucosamine by a combination of chemical/enzymatic tagging, photochemical cleavage, and electron transfer dissociation mass spectrometry.

the homeostatic level of Syn G in RGC-5 cells is required for transcriptional regulation of protein kinases and phosphatases, controlling phosphorylation of Bad and 14-3-3
Title: Effect of gamma-synuclein silencing on apoptotic pathways in retinal ganglion cells.

gamma-Synuclein is selectively and abundantly expressed in human retinal ganglion cells (RGCs) in vivo, primary rat RGCs in vitro, and immortalized RGC-5 cells.
Title: Gamma-synuclein as a marker of retinal ganglion cells.

Coinjection of lentiviruses expressing DAT and gamma-synuclein - leading to overexpression of both proteins in the NAc - resulted in a strong increase in cocaine-induced rat locomotor activity suggesting a synergetic role of both proteins.
Title: The role of gamma-synuclein in cocaine-induced behaviour in rats.

The following Sncg gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sncg cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13759	NM_031688.1 Latest version!	Rattus norvegicus synuclein, gamma (Sncg), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone	40% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sncg ( NM_031688.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113876.1 Rattus norvegicus synuclein, gamma (Sncg), mRNA.

Price & Availability↑

CloneID	ORa13759
Clone ID Related Accession (Same CDS sequence)	NM_031688.1
Accession Version	NM_031688.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 372bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Rattus norvegicus(Norway rat)
Product	gamma-synuclein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X86789.1. On Aug 30, 2004 this sequence version replaced XM_346481.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X86789.1, CF975702.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGACGTCT TCAAGAAAGG CTTCTCCATT GCCAGGGAAG GCGTTGTGGG TGCTGTGGAG 
AAGACCACGC AGGGGGTGAC CGAGGCAGCT GAGAAGACCA AGGAAGGGGT CATGTATGTG 
GGCGCCAAAA CCAAGGGAGA ACGTGGTACA AGTGTAACCT CGGTGGCTGA GAAGACCAAG 
GAGCAGGCCA ATGCCGTGAG TGAAGCTGTG GTCAGCAGCG TCAACACAGT GGCCACCGAG 
ACCGTGGAGG AGGCAGAAAA CATCGTGGTC ACCACCGGGG TAGTACGCAA GGAGGACTTG 
GAACCCCCTG CACAGGACCA GGAGGCCAAA GAGCAAGAGG AGGGCGAAGA GGCCAAGAGT 
GGAGGTGACT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113876.1
CDS	51..422
Translation	MDVFKKGFSIAREGVVGAVEKTTQGVTEAAEKTKEGVMYVGAKTKGERGTSVTSVAEKTKEQANAVSEAVVSSVNTVATETVEEAENIVVTTGVVRKEDLEPPAQDQEAKEQEEGEEAKSGGD

Target ORF information:

RefSeq Version	NM_031688.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus synuclein, gamma (Sncg), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031688.1

ORF Insert Sequence:

ATGGACGTCT TCAAGAAAGG CTTCTCCATT GCCAGGGAAG GCGTTGTGGG TGCTGTGGAG 
AAGACCACGC AGGGGGTGAC CGAGGCAGCT GAGAAGACCA AGGAAGGGGT CATGTATGTG 
GGCGCCAAAA CCAAGGGAGA ACGTGGTACA AGTGTAACCT CGGTGGCTGA GAAGACCAAG 
GAGCAGGCCA ATGCCGTGAG TGAAGCTGTG GTCAGCAGCG TCAACACAGT GGCCACCGAG 
ACCGTGGAGG AGGCAGAAAA CATCGTGGTC ACCACCGGGG TAGTACGCAA GGAGGACTTG 
GAACCCCCTG CACAGGACCA GGAGGCCAAA GAGCAAGAGG AGGGCGAAGA GGCCAAGAGT 
GGAGGTGACT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A decrease in gamma-synuclein expression within the nucleus accumbens increases cocaine intravenous self-administration in the rat.
Addiction biology16(1)120-3(2011 Jan)
Boyer F,Balado E,Piazza PV,Dreyer JL,Deroche-Gamonet V

???-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction.
Proceedings of the National Academy of Sciences of the United States of America107(45)19573-8(2010 Nov)
Greten-Harrison B,Polydoro M,Morimoto-Tomita M,Diao L,Williams AM,Nie EH,Makani S,Tian N,Castillo PE,Buchman VL,Chandra SS

Association of alpha-, beta-, and gamma-Synuclein with diffuse lewy body disease.
Archives of neurology67(8)970-5(2010 Aug)
Nishioka K,Wider C,Vilari?o-G?ell C,Soto-Ortolaza AI,Lincoln SJ,Kachergus JM,Jasinska-Myga B,Ross OA,Rajput A,Robinson CA,Ferman TJ,Wszolek ZK,Dickson DW,Farrer MJ

Enrichment and site mapping of O-linked N-acetylglucosamine by a combination of chemical/enzymatic tagging, photochemical cleavage, and electron transfer dissociation mass spectrometry.
Molecular & cellular proteomics : MCP9(1)153-60(2010 Jan)
Wang Z,Udeshi ND,O'Malley M,Shabanowitz J,Hunt DF,Hart GW

Desipramine induced changes in the norepinephrine transporter, alpha- and gamma-synuclein in the hippocampus, amygdala and striatum.
Neuroscience letters467(2)86-9(2009 Dec)
Jeannotte AM,McCarthy JG,Sidhu A