Defb42 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Defb42
Entrez Gene ID	641657
Full Name	defensin beta 42
General protein information	Preferred Names defensin beta 42 Names beta-defensin 109 beta-defensin 42
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 15 Map Location: 15p12

mRNA and Protein(s)

mRNA	Protein	Name
NM_001037532.1	NP_001032621.1	beta-defensin 109 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Defb48	NP_001032840.1
Rattus norvegicus (Norway rat)	Defb42	NP_001032621.1
Pan troglodytes (chimpanzee)	LOC100170034	NP_001123231.1
	LOC695446	XP_001084318.1

Gene Ontology
Bibliography

Related articles in PubMed

Characterization of ?-defensin 42 expressed in principal cells at the initial segment of the rat epididymis.
Xin A, Zhao Y, Yu H, Shi H, Diao H, Zhang Y
Acta biochimica et biophysica Sinica47(11)861-9(2015 Nov)

Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
Patil AA, Cai Y, Sang Y, Blecha F, Zhang G
Physiological genomics23(1)5-17(2005 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In this study, rat beta-defensin 42 (Defb42) was revealed to be exclusively located in the principal cells at the initial segment of the rat epididymis and its sperm's acrosome; recombinant Defb42 was predominantly antimicrobial not against Candida albicans, but against Escherichia coli and Staphylococcus aureus. Defb42 was suggested to play a dual role in sperm fertility
Title: Characterization of ?-defensin 42 expressed in principal cells at the initial segment of the rat epididymis.

The following Defb42 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Defb42 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09415	NM_001037532.1 Latest version!	Rattus norvegicus defensin beta 42 (Defb42), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Defb42 ( NM_001037532.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001032621.1 Rattus norvegicus defensin beta 42 (Defb42), mRNA.

Price & Availability↑

CloneID	ORa09415
Clone ID Related Accession (Same CDS sequence)	NM_001037532.1
Accession Version	NM_001037532.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 264bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	beta-defensin 109 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY621369.1. ##Evidence-Data-START## Transcript exon combination :: AY621369.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN02642709, SAMN02642711 [ECO:0000348] ##Evidence-Data-END##

ATGAGACTGT ATCTGCTCCT CTCTACGCTA CTCTTCCTCT TGGGCCTCTT ACCCCGAGTT 
AGAAGTGGTT TAGGAGCAGC CGAGACGCAC TGTGTCAACC TTCAGGGCAT TTGCAGAAGA 
GACATTTGTA AACTGATAGA AGACGAAATT GGCGCGTGCC GGAGAAGATG GAAATGCTGC 
AGGCTGTGGT GGGTTCTCCT GCCCATTCCA ACCCCAGTTA TCTTCTCAGA CTATCAAGAG 
CCCCTCCAGA CTAAGATGAA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001032621.1
CDS	1..264
Translation	MRLYLLLSTLLFLLGLLPRVRSGLGAAETHCVNLQGICRRDICKLIEDEIGACRRRWKCCRLWWVLLPIPTPVIFSDYQEPLQTKMK

Target ORF information:

RefSeq Version	NM_001037532.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus defensin beta 42 (Defb42), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037532.1

ORF Insert Sequence:

ATGAGACTGT ATCTGCTCCT CTCTACGCTA CTCTTCCTCT TGGGCCTCTT ACCCCGAGTT 
AGAAGTGGTT TAGGAGCAGC CGAGACGCAC TGTGTCAACC TTCAGGGCAT TTGCAGAAGA 
GACATTTGTA AACTGATAGA AGACGAAATT GGCGCGTGCC GGAGAAGATG GAAATGCTGC 
AGGCTGTGGT GGGTTCTCCT GCCCATTCCA ACCCCAGTTA TCTTCTCAGA CTATCAAGAG 
CCCCTCCAGA CTAAGATGAA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Characterization of ?-defensin 42 expressed in principal cells at the initial segment of the rat epididymis.
Acta biochimica et biophysica Sinica47(11)861-9(2015 Nov)
Xin A,Zhao Y,Yu H,Shi H,Diao H,Zhang Y

Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
Physiological genomics23(1)5-17(2005 Sep)
Patil AA,Cai Y,Sang Y,Blecha F,Zhang G