Fgf14 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fgf14
Entrez Gene ID	63851
Full Name	fibroblast growth factor 14
Synonyms	Fhf4
General protein information	Preferred Names fibroblast growth factor 14 Names fibroblast growth factor 14 FGF homologus factor 4b FGF-14 fibroblast growth factor homologous factor 4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 15 Map Location: 15q25
Summary	exhibits transforming growth factor activity [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017599795.1	XP_017455284.1	fibroblast growth factor 14 isoform X1
NM_022223.2	NP_071559.2	fibroblast growth factor 14

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Fgf14	NP_071559.2
Pan troglodytes (chimpanzee)	FGF14	XP_001150157.1
Xenopus tropicalis (tropical clawed frog)	fgf14	NP_001136296.1
	FGF14	XP_001093573.1
Danio rerio (zebrafish)	fgf14	NP_001012382.1
Homo sapiens (human)	FGF14	NP_004106.1
Mus musculus (house mouse)	Fgf14	NP_034331.2
Canis lupus familiaris (dog)	FGF14	XP_542656.2

Gene Ontology
Bibliography

Related articles in PubMed

Identifying a kinase network regulating FGF14:Nav1.6 complex assembly using split-luciferase complementation.
Hsu WC, Nenov MN, Shavkunov A, Panova N, Zhan M, Laezza F
PloS one10(2)e0117246(2015)

The fibroblast growth factor 14?voltage-gated sodium channel complex is a new target of glycogen synthase kinase 3 (GSK3).
Shavkunov AS, Wildburger NC, Nenov MN, James TF, Buzhdygan TP, Panova-Elektronova NI, Green TA, Veselenak RL, Bourne N, Laezza F
The Journal of biological chemistry288(27)19370-85(2013 Jul)

FGF14 regulates presynaptic Ca2+ channels and synaptic transmission.
Yan H, Pablo JL, Pitt GS
Cell reports4(1)66-75(2013 Jul)

Fibroblast growth factor homologous factors control neuronal excitability through modulation of voltage-gated sodium channels.
Goldfarb M, Schoorlemmer J, Williams A, Diwakar S, Wang Q, Huang X, Giza J, Tchetchik D, Kelley K, Vega A, Matthews G, Rossi P, Ornitz DM, D'Angelo E
Neuron55(3)449-63(2007 Aug)

Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs.
Olsen SK, Garbi M, Zampieri N, Eliseenkova AV, Ornitz DM, Goldfarb M, Mohammadi M
The Journal of biological chemistry278(36)34226-36(2003 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

identified the PI3K/Akt pathway, the cell-cycle regulator Wee1 kinase, and protein kinase C (PKC) as prospective regulatory nodes of neuronal excitability through modulation of the FGF14:Nav1.6 complex.
Title: Identifying a kinase network regulating FGF14:Nav1.6 complex assembly using split-luciferase complementation.

inhibition of GSK3 reduces the assembly of the FGF14.Nav channel complex, modifies FGF14-dependent regulation of Na(+) currents, and induces dissociation and subcellular redistribution of the native FGF14.Nav channel complex in hippocampal neurons.
Title: The fibroblast growth factor 14?voltage-gated sodium channel complex is a new target of glycogen synthase kinase 3 (GSK3).

FGF14 regulates presynaptic Ca2+ channels in granule cell and EPSCs in Purkinje cells.
Title: FGF14 regulates presynaptic Ca2+ channels and synaptic transmission.

The following Fgf14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fgf14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05473	NM_022223.2 Latest version!	Rattus norvegicus fibroblast growth factor 14 (Fgf14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
ORa58644	XM_017599795.1 Latest version!	Rattus norvegicus fibroblast growth factor 14 (Fgf14), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fgf14 ( NM_022223.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_071559.2 Rattus norvegicus fibroblast growth factor 14 (Fgf14), mRNA.

Price & Availability↑

CloneID	ORa05473
Clone ID Related Accession (Same CDS sequence)	NM_022223.2
Accession Version	NM_022223.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 744bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-21
Organism	Rattus norvegicus(Norway rat)
Product	fibroblast growth factor 14
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB079500.1. On Mar 7, 2002 this sequence version replaced NM_022223.1. ##Evidence-Data-START## Transcript exon combination :: AB079500.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCCGCGG CCATCGCCAG CGGCTTGATC CGTCAGAAGC GGCAGGCGCG GGAGCAGCAC 
TGGGACCGGC CCTCTGCCAG CAGGAGGCGG AGCAGCCCCA GCAAGAACCG CGGGCTTTGC 
AATGGCAACC TAGTGGATAT CTTCTCCAAA GTGCGCATCT TCGGCCTCAA GAAGCGCAGG 
TTGCGGCGCC AAGATCCCCA GCTCAAGGGC ATAGTGACCA GGTTATATTG CAGGCAAGGT 
TACTACTTGC AGATGCACCC GGATGGAGCT CTCGATGGAA CTAAGGATGA CAGCACCAAT 
TCCACTCTGT TCAACCTCAT CCCAGTGGGA CTGCGTGTTG TTGCCATCCA GGGAGTGAAG 
ACAGGGTTGT ACATAGCAAT GAACGGCGAA GGTTACCTCT ACCCATCAGA ACTTTTTACT 
CCTGAATGCA AGTTTAAAGA GTCTGTTTTT GAAAACTATT ATGTAATCTA CTCATCCATG 
CTGTACAGGC AACAGGAGTC TGGCAGAGCC TGGTTTTTGG GATTAAATAA GGAAGGGCAA 
GTTATGAAAG GAAACAGAGT AAAGAAAACC AAACCAGCAG CTCATTTTCT ACCCAAGCCA 
TTGGAAGTTG CCATGTACCG AGAACCATCT TTGCATGATG TTGGTGAAAC AGTCCCGAAA 
GCTGGGGTGA CACCAAGCAA AAGTACAAGT GCATCTGCAA TAATGAATGG AGGCAAACCA 
GTCAACAAGT GCAAGACCAC ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071559.2
CDS	1..744
Translation	MAAAIASGLIRQKRQAREQHWDRPSASRRRSSPSKNRGLCNGNLVDIFSKVRIFGLKKRRLRRQDPQLKGIVTRLYCRQGYYLQMHPDGALDGTKDDSTNSTLFNLIPVGLRVVAIQGVKTGLYIAMNGEGYLYPSELFTPECKFKESVFENYYVIYSSMLYRQQESGRAWFLGLNKEGQVMKGNRVKKTKPAAHFLPKPLEVAMYREPSLHDVGETVPKAGVTPSKSTSASAIMNGGKPVNKCKTT

Target ORF information:

RefSeq Version	NM_022223.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus fibroblast growth factor 14 (Fgf14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022223.2

ORF Insert Sequence:

ATGGCCGCGG CCATCGCCAG CGGCTTGATC CGTCAGAAGC GGCAGGCGCG GGAGCAGCAC 
TGGGACCGGC CCTCTGCCAG CAGGAGGCGG AGCAGCCCCA GCAAGAACCG CGGGCTTTGC 
AATGGCAACC TAGTGGATAT CTTCTCCAAA GTGCGCATCT TCGGCCTCAA GAAGCGCAGG 
TTGCGGCGCC AAGATCCCCA GCTCAAGGGC ATAGTGACCA GGTTATATTG CAGGCAAGGT 
TACTACTTGC AGATGCACCC GGATGGAGCT CTCGATGGAA CTAAGGATGA CAGCACCAAT 
TCCACTCTGT TCAACCTCAT CCCAGTGGGA CTGCGTGTTG TTGCCATCCA GGGAGTGAAG 
ACAGGGTTGT ACATAGCAAT GAACGGCGAA GGTTACCTCT ACCCATCAGA ACTTTTTACT 
CCTGAATGCA AGTTTAAAGA GTCTGTTTTT GAAAACTATT ATGTAATCTA CTCATCCATG 
CTGTACAGGC AACAGGAGTC TGGCAGAGCC TGGTTTTTGG GATTAAATAA GGAAGGGCAA 
GTTATGAAAG GAAACAGAGT AAAGAAAACC AAACCAGCAG CTCATTTTCT ACCCAAGCCA 
TTGGAAGTTG CCATGTACCG AGAACCATCT TTGCATGATG TTGGTGAAAC AGTCCCGAAA 
GCTGGGGTGA CACCAAGCAA AAGTACAAGT GCATCTGCAA TAATGAATGG AGGCAAACCA 
GTCAACAAGT GCAAGACCAC ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fgf14 ( XM_017599795.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017455284.1 Rattus norvegicus fibroblast growth factor 14 (Fgf14), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa58644
Clone ID Related Accession (Same CDS sequence)	XM_017599795.1
Accession Version	XM_017599795.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 759bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	fibroblast growth factor 14 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTAAAAC CGGTGCCCCT CTTCAGGAGA ACTGATTTCA AGTTATTATT ATGCAACCAC 
AAGGGCCTCT TCTTTCTCAG GGTGTCTAAG CTGCTGGGTT GCTTTTCGCC CAAATCAATG 
TGGTTTCTTT GGAACATTTT CAGCAAAGGA ACGCATATGC TGCAGTGTCT TTGTGGCAAG 
AGTCTTAAGA AAAACAAGAA CCCAACTGAT CCCCAGCTCA AGGGCATAGT GACCAGGTTA 
TATTGCAGGC AAGGTTACTA CTTGCAGATG CACCCCGATG GAGCTCTCGA TGGAACTAAG 
GATGACAGCA CCAATTCCAC TCTGTTCAAC CTCATCCCAG TGGGACTGCG TGTTGTTGCC 
ATCCAGGGAG TGAAGACAGG GTTGTACATA GCAATGAATG GAGAAGGTTA CCTCTACCCA 
TCAGAACTTT TTACTCCTGA ATGCAAGTTT AAAGAGTCTG TTTTTGAAAA CTATTATGTA 
ATCTACTCAT CCATGCTGTA CAGGCAACAG GAGTCTGGCA GAGCCTGGTT TTTGGGATTA 
AATAAGGAAG GGCAAGTTAT GAAAGGAAAC AGAGTAAAGA AAACCAAACC AGCAGCTCAT 
TTTCTACCCA AGCCATTGGA AGTTGCCATG TACCGAGAAC CATCTTTGCA TGATGTTGGT 
GAAACAGTCC CGAAAGCTGG GGTGACACCA AGCAAAAGTA CAAGTGCATC TGCAATAATG 
AATGGAGGCA AACCAGTCAA CAAGTGCAAG ACCACATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017455284.1
CDS	891..1649
Translation	MVKPVPLFRRTDFKLLLCNHKGLFFLRVSKLLGCFSPKSMWFLWNIFSKGTHMLQCLCGKSLKKNKNPTDPQLKGIVTRLYCRQGYYLQMHPDGALDGTKDDSTNSTLFNLIPVGLRVVAIQGVKTGLYIAMNGEGYLYPSELFTPECKFKESVFENYYVIYSSMLYRQQESGRAWFLGLNKEGQVMKGNRVKKTKPAAHFLPKPLEVAMYREPSLHDVGETVPKAGVTPSKSTSASAIMNGGKPVNKCKTT

Target ORF information:

RefSeq Version	XM_017599795.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus fibroblast growth factor 14 (Fgf14), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017599795.1

ORF Insert Sequence:

ATGGTAAAAC CGGTGCCCCT CTTCAGGAGA ACTGATTTCA AGTTATTATT ATGCAACCAC 
AAGGGCCTCT TCTTTCTCAG GGTGTCTAAG CTGCTGGGTT GCTTTTCGCC CAAATCAATG 
TGGTTTCTTT GGAACATTTT CAGCAAAGGA ACGCATATGC TGCAGTGTCT TTGTGGCAAG 
AGTCTTAAGA AAAACAAGAA CCCAACTGAT CCCCAGCTCA AGGGCATAGT GACCAGGTTA 
TATTGCAGGC AAGGTTACTA CTTGCAGATG CACCCCGATG GAGCTCTCGA TGGAACTAAG 
GATGACAGCA CCAATTCCAC TCTGTTCAAC CTCATCCCAG TGGGACTGCG TGTTGTTGCC 
ATCCAGGGAG TGAAGACAGG GTTGTACATA GCAATGAATG GAGAAGGTTA CCTCTACCCA 
TCAGAACTTT TTACTCCTGA ATGCAAGTTT AAAGAGTCTG TTTTTGAAAA CTATTATGTA 
ATCTACTCAT CCATGCTGTA CAGGCAACAG GAGTCTGGCA GAGCCTGGTT TTTGGGATTA 
AATAAGGAAG GGCAAGTTAT GAAAGGAAAC AGAGTAAAGA AAACCAAACC AGCAGCTCAT 
TTTCTACCCA AGCCATTGGA AGTTGCCATG TACCGAGAAC CATCTTTGCA TGATGTTGGT 
GAAACAGTCC CGAAAGCTGG GGTGACACCA AGCAAAAGTA CAAGTGCATC TGCAATAATG 
AATGGAGGCA AACCAGTCAA CAAGTGCAAG ACCACATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identifying a kinase network regulating FGF14:Nav1.6 complex assembly using split-luciferase complementation.
PloS one10(2)e0117246(2015)
Hsu WC,Nenov MN,Shavkunov A,Panova N,Zhan M,Laezza F

The fibroblast growth factor 14?voltage-gated sodium channel complex is a new target of glycogen synthase kinase 3 (GSK3).
The Journal of biological chemistry288(27)19370-85(2013 Jul)
Shavkunov AS,Wildburger NC,Nenov MN,James TF,Buzhdygan TP,Panova-Elektronova NI,Green TA,Veselenak RL,Bourne N,Laezza F

FGF14 regulates presynaptic Ca2+ channels and synaptic transmission.
Cell reports4(1)66-75(2013 Jul)
Yan H,Pablo JL,Pitt GS

Fibroblast growth factor homologous factors control neuronal excitability through modulation of voltage-gated sodium channels.
Neuron55(3)449-63(2007 Aug)
Goldfarb M,Schoorlemmer J,Williams A,Diwakar S,Wang Q,Huang X,Giza J,Tchetchik D,Kelley K,Vega A,Matthews G,Rossi P,Ornitz DM,D'Angelo E

Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs.
The Journal of biological chemistry278(36)34226-36(2003 Sep)
Olsen SK,Garbi M,Zampieri N,Eliseenkova AV,Ornitz DM,Goldfarb M,Mohammadi M